β-adrenoceptor activation plays a role in the reverse rate-dependency of effective refractory period lengthening by dofetilide in the guinea-pig atrium, in vitro

British Journal of Pharmacology

Volumn 139, Issue 8, 2003, Pages 1555-1563

  Kovács, Anikó ^a   Magyar, János ^b   Bányász, Tamás ^b   Nánási, Péter P ^b   Szénási, Gábor ^a  

^a EGIS PHARMACEUTICALS LTD   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Atenolol; Atrium; Catecholamine depletion; Dofetilide; Guinea pig; Metoprolol; Propranolol; Rate dependence; Refractoriness; Reserpine

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DOFETILIDE; ISOPRENALINE; METOPROLOL; NORADRENALIN; PROPRANOLOL; RESERPINE;

ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CATECHOLAMINE DEPLETION; CHRONOTROPISM; CONTROLLED STUDY; DRUG EFFECT; GUINEA PIG; HEART ATRIUM MUSCLE; HEART LEFT ATRIUM; HEART MUSCLE REFRACTORY PERIOD; HEART MUSCLE TENSION; HEART PAPILLARY MUSCLE; HEART VENTRICLE WALL; IN VITRO STUDY; MALE; MUSCLE LENGTH; MUSCLE TWITCH; NONHUMAN; NORADRENALIN RELEASE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARDIAC PACING, ARTIFICIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; GUINEA PIGS; HEART ATRIA; MALE; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; PHENETHYLAMINES; POTASSIUM CHANNEL BLOCKERS; RABBITS; RECEPTORS, ADRENERGIC, BETA; SULFONAMIDES;

EID: 0141540407     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705395     Document Type: Article

References (64)

1. BASKIN, E.P. & LYNCH, J.J. (1998). Differential atrial versus ventricular activities of class III potassium channel blockers. J. Pharmacol. Exp. Ther., 285, 135-142.
2. BERMAN, N.D. & DORIAN, P. (1993). Cellular mechanism underlying the efficacy of the sotalol-quinidine combination. J. Cardiovasc. Pharmacol., 21, 609-614.
3. BILICZKI, P., VIRAG, L., IOST, N., PAPP, J.G. & VARRO, A. (2002). Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve. Br. J. Pharmacol., 137, 361-368.
4. BOYETT, N.R. & FEDIDA, D. (1984). Changes in the electrical activity of the dog Purkinje fibers at high heart rates. J. Physiol. (London), 350, 361-391.
5. + channels in mouse atrial myocytes. J. Biol. Chem., 276, 159-164.
6. f: origins and developments. Prog. Biophys. Mol. Biol., 46, 163-183.
7. FEDIDA, D., SHIMONI, Y. & GILES, W.R. (2000). Alpha-adrenergic modulation of the transient outward current in rabbit atrial myocytes. J Physiol. (London), 423, 257-277.
8. FEDIDA, D., SHIMONI, Y. & GILES, W.R. (1989). A novel effect of noradrenaline on cardiac cells is mediated by alpha 1-adrenoceptors. Am. J. Physiol., 256, H1500-H1504.
9. FOUCART, S. & MAJEWSKI, H. (1989). Inhibition of noradrenaline release by neuropeptide Y in mouse atria does not involve inhibition of adenylate cyclase or a pertussis toxin-susceptible G protein. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 658-665.
10. GINTANT, G.A. (1998). Azimilide causes reverse rate-dependent block while reducing both components of cardiac delayed rectifier current in canine ventricular myocytes. J. Cardiovasc. Pharmacol., 31, 945-953.
11. GROH, W.J., GIBSON, K.J. & MAYLIE, J.G. (1997). Comparison of the rate-dependent properties of the class III antiarrhythmic agents azimilide (NE-10064) and E-4031: considerations on the mechanism of reverse rate-dependent action potential prolongation. J. Cardiovasc. Electrophysiol., 8, 529-536.
12. GWILT, M., WILLIAMS, R.C. & HIGGINS, A.J. (1991). Effects of action potential prolongation via different cellular mechanisms on the electrophysiological properties of rat and guinea-pig ventricular myocardium. Arch. Int. Pharmacodyn. Ther., 312, 66-78.
13. HAFNER, D., BERGER, F., BORCHARD, A., KULLMANN, A. & SCHERLITZ, A. (1988). Electrophysiological characterisation of the class III activity of sotalol and its enantiomers. New interpretation of use-dependent effects. Arzneim.-Forsch. Drug Res., 38, 231-237.
14. HARVEY, R.D. & HUME, J.R. (1989). Isoproterenol activates a chloride current, not the transient outward current, in rabbit ventricular myocytes. Am. J. Physiol., 253, C1177-C1181.
15. Kr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes. J. Physiol. (London), 522, 391-402.
16. HOFFMANN, B.F. & SINGER, D. (1967). Appraisal the effects of catecholamines on cardiac electrical activity. Ann. NY Acad. Sci., 193, 914-924.
17. HONDEGHEM, L.M. & SNYDERS, D.J. (1990). Class III antiarrhythmic agents have a lot of potential but a long way to go: reduced effectiveness and dangers of reverse use dependence. Circulation, 81, 686-690.
18. 2+ channels in guinea pig ventricular myocytes. Am. J. Physiol., 273, H1669-H1676.
19. HUME, J.R. & UEHARA, A. (1985). Ionic basis of the different action potential configurations of single guinea pig atrial and ventricular myocytes. J. Physiol. (London), 368, 525-544.
20. IOST, N., VIRÁG, L., OPANCARIU, M., VARRÓ, A. & PAPP, J.G.Y. (1998). Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc. Res., 40, 508-515.
21. ISHII, Y., MURAKI, K., KURIHARA, A., IMAIZUMI, Y. & WATANABE, M. (1995). Effects of sematilide, a novel class III antiarrhythmic agent, on action potential in guinea pig atrium. Jpn. J. Pharmacol., 68, 175-182.
22. JAZAYERI, M.R., VAN WYHE, G., AVITALL, B., MCKINNIE, J., TCHOU, P. & AKHTAR, M. (1989). Isoproterenol reversal of antiarrhythmic effects in patients with inducible sustained ventricular tachyarrhythmias. J. Am. Coll. Cardiol., 14, 705-711.
23. JOHNSTON, H. & MAJEWSKI, H. (1986). Prejunctional beta-adrenoceptors in rabbit pulmonary artery and mouse atria: effect of alpha-adrenoceptor blockade and phosphodiesterase inhibition. Br. J. Pharmacol., 87, 553-562.
24. JUNSTAD, M. & WENNMALM, A. (1973). Prostaglandin mediated inhibition of noradrenaline release at different nerve impulses. Acta Physiol. Scand., 89, 544-549.
25. + current by dofetilide. Circ. Res., 71, 75-83.
26. KIEHN, J., KARLE, C., THOMAS, D., YAO, X., BRACHMANN, J. & KUBLER, W. (1998). HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. J. Biol. Chem., 273, 25285-25291.
27. KOVÁCS, A., GYÖNÖS, I., MAGYAR, J., BÁNYÁ SZ, T., NÁNÁSI, P.P., SPEDDING, M. & SZÉNÁSI, G. (2001). Effects of EGIS-7229 (S 21407), a novel class III antiarrhythmic drug, on myocardial refractoriness to electrical stimulation in vivo and in vitro. J. Cardiovasc. Pharmacol., 37, 78-88.
28. LAMONTAGNE, D., YAMAGUCHI, N., LAMBERT, C., DE CHAMPLAIN, J. & NADEAU, R. (1990). Absence of prejunctional sympathetic effect of amiodarone in hearts of open-chest anesthetized dogs. Can. J. Physiol. Pharmacol., 68, 144-149.
29. LEE, K., LEE, J.Y., KIM, H.Y., KWON, L.S., SHIN, H.S., TANABE, S., KOZONO, T., PARK, S.D. & CHUNG, Y.S. (1998). KCB-328: a novel class III antiarrhythmic agent with little reverse frequency dependence in isolated guinea pig myocardium. J. Cardiovasc. Pharmacol., 31, 609-617.
30. c and action potential duration. Br. J. Pharmacol., 132, 101-110.
31. + current in human atrial myocytes. Circ. Res, 78, 903-915.
32. LI, H.T., WANG, Y.Q., DAI, D.Z. & KONG, R.Z. (2001). Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017. Acta Pharmacol. Sin., 22, 32-36.
33. LIU, H., JI, M., LUO, X., SHEN, J., HUANG, X., HUA, W., JIANG, H. & CHEN, K. (2002). New p-methylsulfonamido phenylethylamine analogues as class III antiarrhythmic agents: design, synthesis, biological assay, and 3D-QSAR analysis. J. Med. Chem., 45, 2953-2969.
34. LOIACONO, R.E. & STORY, D.F. (1986). Effect of alpha-adrenoceptor agonists and antagonists on cholinergic transmission in guinea-pig isolated atria. Naunyn-Schmiedeberg's Arch. Pharmacol., 334, 40-47.
35. Kr, and effects on myocardial refractoriness for class III antiarrhythmic agents. J. Cardiovasc. Pharmacol., 25, 336-340.
36. MARSCHANG, H., BRACHMANN, J., KAROLYI, L., KÜBLER, W. & SCHÖLS, W. (2000). Isoproterenol specifically modulates reverse rate-dependent effects of D,L-sotalol, D-sotalol, and dofetilide. J. Cardiovasc. Pharmacol., 35, 443-450.
37. MARSCHANG, H., BEYER, T., KAROLYI, L., KÜBLER, W. & BRACHMANN, J. (1998). Differential rate and potassium-dependent effects of the class III agents D-sotalol and dofetilide on guinea pig papillary muscle. Cardiovasc. Drugs Ther., 12, 573-583.
38. MARTIN, C.L., PALOMO, M.A. & MCMAHON, E.G. (1996). Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol. J. Pharmacol. Exp. Ther., 278, 154-162.
39. MATSUDA, J.J., LEE, H. & SHIBATA, E.F. (1992). Enhancement of rabbit cardiac sodium channels by β-adrenergic stimulation. Circ. Res., 70, 199-207.
40. MOLDERINGS, G.J., LIKUNGU, J. & GOTHERT, M. (2000). N-type calcium channels control sympathetic neurotransmission in human heart atrium. Circulation, 101, 403-407.
41. MURPHY, T.V., FOUCART, S. & MAJEWSKI, H. (1992). Prejunctional alpha 2-adrenoceptors in mouse atria function through G-proteins which are sensitive to N-ethylmaleimide, but not pertussis toxin. Br. J. Pharmacol., 106, 871-876.
42. NAKAYAMA, T. & FOZZARD, H.A. (1988). Adrenergic modulation of the transient outward current, in rabbit ventricular myocytes. Circ. Res., 62, 162-172.
43. NEWMAN, D., DORIAN, P. & FEDER-ELITUV, R. (1993). Isoproterenol antagonises drug-induced prolongation of action potential duration in humans. Can. J. Physiol. Pharmacol., 71, 755-760.
44. NOBLE, D. & TSIEN, R.W. (1969). Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J. Physiol. (London), 200, 205-231.
45. + current in guinea-pig atrial cells, Br. J. Pharmacol., 126, 751-761.
46. - current in guinea pig ventricular myocytes. Circ. Res., 78, 1090-1099.
47. PANKUCSI, C., BÁNYÁSZ, T., MAGYAR, J., GYÖNÖS, I., KOVÁCS, A., SZÉNÁSI, G., VARRÓ, A. & NÁNÁSI, P.P. (1997). Electrophysiological effects of EGIS-7229, a new antiarrhythmic agent, in isolated guinea pig papillary muscle. Gen. Pharmacol., 29, 275-280.
48. PICKOFF, A.S. & STOLFI, A. (2001). Comparison of the rate dependent effects of dofetilide and ibutilide in the newborn heart. Pacing Clin. Electrophysiol., 24, 816-823.
49. RAATIKAINEN, M.J., MOREY, T.E., DRUZGALA, P., MILNER, P., GONZALEZ, M.D. & DENNIS, D.M. (2000). Potent and reversible effects of ATI-2001 on atrial and atrioventricular nodal electrophysiological properties in guinea pig isolated perfused heart. J. Pharmacol. Exp. Ther., 295, 779-785.
50. RAMIREZ, R.J., NATTEL, S. & COURTEMANCHE, M. (2000). Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodelling. Am. J. Physiol., 279, H1767-H1785.
51. REUTER, H. (1983). Calcium channel modulation by neurotransmitter, enzymes and drugs. Nature, 301, 569-574.
52. ROCCHETTI, M., BESANA, L., GURROLA, G.B., POSSANI, L.D. & ZAZA, A. (2001). Rate dependency of delayed rectifier currents during the guinea pig ventricular action potential. J. Physiol. (London), 534, 721-732.
53. SAGER, P.T., FOLLMER, C., UPPAL, P., PRUITT, C. & GODFREY, R. (1994). The effects of β-adrenergic stimulation on the frequency-dependent electrophysiologic actions of amiodarone and sematilide in humans. Circulation, 90, 1811-1819.
54. + current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol., 96, 195-215.
55. SANGUINETTI, M.C., JURKIEWITZ, N.K., SCOTT, A. & SIEGL, P.K.S. (1991). Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action. Circ. Res., 68, 77-84.
56. THOMAS, D., ZHANG, W., KARLE, C.A., KATHOFER, S., SCHOLS, W., KUBLER, W. & KIEHN, J. (1999). Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A. J. Biol. Chem., 274, 27457-27462.
57. VARRÓ, A., LATHROP, D.A., HESTER, S.B., NÁNÁSI, P.P. & PAPP, J.G.Y. (1993). Ionic currents and action potentials in rabbit, rat, and guinea-pig ventricular myocytes. Basic Res. Cardiol., 88, 93-102.
58. + currents via different signaling pathways in canine ventricular myocytes. J. Biol. Chem., 276, 40811-40816.
59. WATANABE, H., WATANABE, I., NAKAI, T., OSHIKAWA, N., KUNIMOTO, S., MASAKI, R., KOJIMA, T., SAITO, S., OZAWA, Y. & KANMATUSE, K. (2001). Frequency-dependent electrophysiological effects of fiecainide, nifekalant and D,L-sotalol on the human atrium. Jpn. Circ. J., 65, 1-6.
60. WICHTER, T., SCHAFERS, M., RHODES, C.G., BORGGREFE, M., LERCH, H., LAMMERTSMA, A.A., HERMANSEN, F., SCHOBER, O., BREITHARDT, G. & CAMICI, P.G. (2000). Abnormalities of cardiac sympathetic innervation in arrhythmogenic right ventricular cardiomyopathy: quantitative assessment of presynaptic noradrenaline reuptake and postsynaptic beta-adrenergic receptor density with positron emission tomography. Circulation, 101, 1552-1558.
61. YANG, T.T., TANDE, P.M., LATHROP, D.A. & REFSUM, H. (1992a). Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68,798) in guinea pig papillary muscle. Cardiovasc. Drugs Ther., 6, 429-436.
62. YANG, T.T., TANDE, P.M. & REFSUM, H. (1992b). Electromechanical action of dofetilide and D-sotalol during simulated metabolic acidosis in isolated guinea pig ventricular muscle. Cardiovasc. Pharmacol., 20, 889-894.
63. YUE, L., FENG, J., WANG, Z. & NATTEL, S. (1999). Adrenergic control of the ultrarapid delayed rectifier current in canine atrial myocytes. J. Physiol., 516, 385-398.
64. + channel blockers and muscarinic receptor stimulation. J. Pharmacol. Exp. Ther., 273, 1095-1104.