Isoproterenol specifically modulates reverse rate-dependent effects of d,l-sotalol, d-sotalol, and dofetilide

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 3, 2000, Pages 443-450

  Marschang, Harald ^a,c   Brachmann, Johannes ^b   Karolyi, Laszlo ^a   Kübler, Wolfgang ^a   Schöls, Wolfgang ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b KLINIKUM COBURG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Beagle dogs; Cardiomyocytes; d,l Sotalol; d Sotalol; Dofetilide; Isoproterenol; Reverse rate dependence

Indexed keywords

ANTIARRHYTHMIC AGENT; DOFETILIDE; ISOPRENALINE; SOTALOL;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DOG; DRUG EFFECT; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; MEMBRANE STEADY POTENTIAL; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; REFRACTORY PERIOD; SYMPATHETIC TONE;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CARDIOTONIC AGENTS; DOGS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; HEART; ISOMERISM; ISOPROTERENOL; MEMBRANE POTENTIALS; PHENETHYLAMINES; SOTALOL; SULFONAMIDES;

EID: 0033998347     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200003000-00015     Document Type: Article

References (4)

1. + current: differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 1990;96:195-215.
2. Kiehn J, Villena P, Beyer T, Brachmann J. Differential effects of the new class III agent dofetilide on potassium currents in guinea pig cardiomyocytes. J Cardiovasc Pharmacol 1992;24:566-72.
3. Wettwer E, Grundke M, Ravens U. Differential effects of the new class III antiarrhythmic agents almokalant, E-4031, and d-sotalol, and of quinidine, on delayed rectifier currents in guinea pig ventricular myocytes. Cardiovasc Res 1992;26:1145-52.
4. + current in cardiac myocytes by development. J Pharmacol Exp Ther 1992;262:809-17.