Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters

International Journal of Pharmaceutics

Volumn 265, Issue 1-2, 2003, Pages 75-84

  Wang, Jun ^a,b   Huang, Shi Wen ^a   Zhang, Peng Chi ^a   Mao, Hai Quan ^a,b   Leong, Kam W ^a,b  

^a Johns Hopkins Singapore   (Singapore)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Non viral gene delivery; Polymeric carrier; Polyphosphoester; Sustained release

Indexed keywords

CATION; DRUG CARRIER; LUCIFERASE; NAKED DNA; PHOSPHATE; PLASMID DNA; POLY(6 AMINOHEXYL PROPYLENE PHOSPHATE); POLY(N METHYL 2 AMINOETHYL PROPYLENE PHOSPHATE); UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA TRANSFECTION; DRUG DEGRADATION; DRUG RELEASE; DRUG STRUCTURE; FEMALE; GENE EXPRESSION; GENE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE;

EID: 0141533099     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.07.006     Document Type: Article

References (27)

1. Baran J., Penczek S. Hydrolysis of polyesters of phosphoric acid. 1. Kinetics and the pH profile. Macromolecules. 28:1995;5167-5176.
2. Chen S.C., Jones D.H., Fynan E.F., Farrar G.H., Clegg J.C., Greenberg H.B., Herrmann J.E. Protective immunity induced by oral immunization with a rotavirus DNA vaccine encapsulated in microparticles. J. Virol. 72:1998;5757-5761.
3. Cohen H., Levy R.J., Gao J., Fishbein I., Kousaev V., Sosnowski S., Slomkowski S., Golomb G. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther. 7:2000;1896-1905.
4. Davis M.E. Non-viral gene delivery systems. Curr. Opin. Biotechnol. 13:2002;128-131.
5. Garnett M.C. Gene-delivery systems using cationic polymers. Crit Rev. Ther. Drug Carrier Syst. 16:1999;147-207.
6. Gebhart C.L., Sriadibhatla S., Vinogradov S., Lemieux P., Alakhov V., Kabanov A.V. Design and formulation of polyplexes based on pluronic-polyethyleneimine conjugates for gene transfer. Bioconjug. Chem. 13:2002;937-944.
7. Georgantas R.W. III, Leong K.W., August J.T. Antigen-specific induction of peripheral T cell tolerance in vivo by codelivery of DNA vectors encoding antigen and Fas ligand. Hum. Gene Ther. 11:2000;851-858.
8. Goldman C.K., Soroceanu L., Smith N., Gillespie G.Y., Shaw W., Burgess S., Bilbao G., Curiel D.T. In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer. Nat. Biotechnol. 15:1997;462-466.
9. Greene, T.W., Wuts, P.G.M., 1999. Protective Groups in Organic Synthesis, 2nd ed. Wiley, New York.
10. Han S., Mahato R.I., Sung Y.K., Kim S.W. Development of biomaterials for gene therapy. Mol. Ther. 2:2000;302-317.
11. Klencke B., Matijevic M., Urban R.G., Lathey J.L., Hedley M.L., Berry M., Thatcher J., Weinberg V., Wilson J., Darragh T., Jay N., Da Costa M., Palefsky J.M. Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101. Clin. Cancer Res. 8:2002;1028-1037.
12. Lucas H.J. Jr., Scully C.N. Cyclic phosphites of some aliphatic glycols. J. Am. Chem. Soc. 72:1950;5491-5497.
13. Madsen, S., Mooney, D.J., 2000. Delivering DNA with polymer matrices: applications in tissue engineering and gene therapy 3, 381-384.
14. Mao H.Q., Roy K., Troung L., Janes K.A., Lin K.Y., Wang Y., August J.T., Leong K.W. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J. Control Release. 70:2001;399-421.
15. Penczek S., Pretula J. High-molecular-weight poly(alkylene phosphate)s and preparation of amphiphilic polymers thereof. Macromolecules. 26:1993;2228-2233.
16. Rigby P.W., Rhodes C., Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Biol. 113:1977;237-251.
17. Rolland A.P., Mumper R.J. Plasmid delivery to muscle: recent advances in polymer delivery systems. Adv. Drug Deliv. Rev. 30:1998;151-172.
18. Roy K., Mao H.Q., Huang S.K., Leong K.W. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat. Med. 5:1999;387-391.
19. Wang J., Mao H.Q., Leong K.W. A novel biodegradable gene carrier based on polyphosphoester. J. Am. Chem. Soc. 123:2001;9480-9481.
20. Wang S., Ma N., Gao S.J., Yu H., Leong K.W. Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes. Mol. Ther. 3:2001;658-664.
21. Wang J., Zhang P.C., Lu H.F., Ma N., Wang S., Mao H.Q., Leong K.W. New polyphosphoramidate with a spermidine side chain as a gene carrier. J. Control Release. 83:2002a;157-168.
22. Wang J., Zhang P.C., Mao H.Q., Leong K.W. Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier. Gene Ther. 9:2002b;1254-1261.
23. Wierzbicki A., Kiszka I., Kaneko H., Kmieciak D., Wasik T.J., Gzyl J., Kaneko Y., Kozbor D. Immunization strategies to augment oral vaccination with DNA and viral vectors expressing HIV envelope glycoprotein. Vaccine. 20:2002;1295-1307.
24. Wolff J.A., Dowty M.E., Jiao S., Repetto G., Berg R.K., Ludtke J.J., Williams P., Slautterback D.B. Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle. J. Cell Sci. 103:1992;1249-1259.
25. Yang J.P., Huang L. Direct gene transfer to mouse melanoma by intratumor injection of free DNA. Gene Ther. 3:1996;542-548.
26. Zhou Q.X., Kohn J. Preparation of poly(l-serine ester) - a structural analog of conventional poly(l-serine). Macromolecules. 23:1990;3399-3406.
27. Zuber G., Dauty E., Nothisen M., Belguise P., Behr J.P. Towards synthetic viruses. Adv. Drug Deliv. Rev. 52:2001;245-253.