Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells

Leukemia and Lymphoma

Volumn 43, Issue 9, 2002, Pages 1737-1741

  Boehrer, Simone ^a   Chow, Kai U ^a   Ruthardt, Martin ^a   Hoelzer, Dieter ^a   Mitrou, Paris S ^a   Weidmann, Eckhart ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Apoptosis; Bcl 2; Lymphocytes; Par 4

Indexed keywords

BIOLOGICAL MARKER; CASPASE; CASPASE 3; INHIBITOR OF APOPTOSIS PROTEIN; LEUCINE ZIPPER PROTEIN; PROTEIN BCL 2; PROTEIN PAR 4; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; APOPTOSIS; CELL MEMBRANE POTENTIAL; CHEMOSENSITIVITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DEREGULATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LONGEVITY; LYMPHATIC SYSTEM TUMOR; LYMPHOCYTE; MITOCHONDRIAL MEMBRANE; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; DOWN-REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MODELS, BIOLOGICAL; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0036332898     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819021000006510     Document Type: Review

References (19)

1. "Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells"
2. "Expression and function of the leucine zipper protein Par-4 in apoptosis"
3. "Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues"
4. "The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C"
5. "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1"
6. "Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma"
7. "Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade"
8. "Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4"
9. "The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression"
10. "Oncogenic Ras sensitizes cells to apoptosis by Par-4"
11. "Bcl-2: An antidote to programmed cell death"
12. "Bcl-2: A repressor of lymphocyte death"
13. "Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: Relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance"
14. "Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines"
15. "Bcl-2 family proteins: Regulators of apoptosis and chemoresistance in hematologic malignancies"
16. "Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance [see comments]"
17. "Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia"
18. "In lymphatic cells Par-4 sensitizes to apoptosis by down-regulating Bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation"
19. "Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation"