-
1
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
Artursson P, Karlsson J. 1991. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 175(3):880-885.
-
(1991)
Biochem Biophys Res Commun
, vol.175
, Issue.3
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
2
-
-
0031741846
-
Physical chemical properties of oral drug candidates in the discovery and exploratory development settings
-
Curatolo W. 1998. Physical chemical properties of oral drug candidates in the discovery and exploratory development settings. Pharm Sci Technol Today 1:387.
-
(1998)
Pharm Sci Technol Today
, vol.1
, pp. 387
-
-
Curatolo, W.1
-
3
-
-
0030444550
-
Guidance in the setting of drug particle size specifications to minimize variability in absorption
-
Johnson KC, Swindell AC. 1996. Guidance in the setting of drug particle size specifications to minimize variability in absorption. Pharm Res 13(12): 1795-1798.
-
(1996)
Pharm Res
, vol.13
, Issue.12
, pp. 1795-1798
-
-
Johnson, K.C.1
Swindell, A.C.2
-
4
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
Lipinski CA. 2000. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods 44(1):235-249.
-
(2000)
J Pharmacol Toxicol Methods
, vol.44
, Issue.1
, pp. 235-249
-
-
Lipinski, C.A.1
-
5
-
-
0031962002
-
P-Glycoprotein transporters and the gastrointestinal tract: Evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound
-
Spahn-Langguth H, Baktir G, Radschuweit A, et al. 1998. P-Glycoprotein transporters and the gastrointestinal tract: Evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound. Int J Clin Pharmacol Ther 36(1): 16-24.
-
(1998)
Int J Clin Pharmacol Ther
, vol.36
, Issue.1
, pp. 16-24
-
-
Spahn-Langguth, H.1
Baktir, G.2
Radschuweit, A.3
-
6
-
-
0033328139
-
The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions
-
Yu DK. 1999. The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions. J Clin Pharmacol 39(12):1203-1211.
-
(1999)
J Clin Pharmacol
, vol.39
, Issue.12
, pp. 1203-1211
-
-
Yu, D.K.1
-
7
-
-
0035098868
-
A comprehensive account on the role of efflux transporters in the gastrointestinal absorption of 13 commonly used substrate drugs in humans
-
Chiou WL, Chung SM, Wu TC, Ma C. 2001. A comprehensive account on the role of efflux transporters in the gastrointestinal absorption of 13 commonly used substrate drugs in humans. Int J Clin Pharmacol Ther 39(3):93-101.
-
(2001)
Int J Clin Pharmacol Ther
, vol.39
, Issue.3
, pp. 93-101
-
-
Chiou, W.L.1
Chung, S.M.2
Wu, T.C.3
Ma, C.4
-
8
-
-
0033514320
-
Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
-
Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM. 1999. Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [see comments]. Circulation 99(4):552-557.
-
(1999)
Circulation
, vol.99
, Issue.4
, pp. 552-557
-
-
Fromm, M.F.1
Kim, R.B.2
Stein, C.M.3
Wilkinson, G.R.4
Roden, D.M.5
-
9
-
-
0035987082
-
Drug interaction studies between paclitaxel (Taxol) and OC144-093-A new modulator of MDR in cancer chemotherapy
-
Guns ES, Denyssevych T, Dixon R, Bally MB, Mayer L. 2002. Drug interaction studies between paclitaxel (Taxol) and OC144-093-A new modulator of MDR in cancer chemotherapy. Eur J Drug Metab Pharmacokinet 27(2):119-126.
-
(2002)
Eur J Drug Metab Pharmacokinet
, vol.27
, Issue.2
, pp. 119-126
-
-
Guns, E.S.1
Denyssevych, T.2
Dixon, R.3
Bally, M.B.4
Mayer, L.5
-
10
-
-
0032804327
-
Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor
-
Polli JW, Jarrett JL, Studenberg SD, et al. 1999. Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor. Pharm Res 16(8):1206-1212.
-
(1999)
Pharm Res
, vol.16
, Issue.8
, pp. 1206-1212
-
-
Polli, J.W.1
Jarrett, J.L.2
Studenberg, S.D.3
-
11
-
-
0035876039
-
Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin
-
Peck RA, Hewett J, Harding MW, et al. 2001. Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin. J Clin Oncol 19(12):3130-3141.
-
(2001)
J Clin Oncol
, vol.19
, Issue.12
, pp. 3130-3141
-
-
Peck, R.A.1
Hewett, J.2
Harding, M.W.3
-
12
-
-
0032793959
-
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
-
Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB. 1999. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27(6):866-871.
-
(1999)
Drug Metab Dispos
, vol.27
, Issue.6
, pp. 866-871
-
-
Cvetkovic, M.1
Leake, B.2
Fromm, M.F.3
Wilkinson, G.R.4
Kim, R.B.5
-
13
-
-
0034467860
-
Influence of passive permeability on apparent P-glycoprotein kinetics
-
Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE. 2000. Influence of passive permeability on apparent P-glycoprotein kinetics. Pharm Res 17(12):1456-1460.
-
(2000)
Pharm Res
, vol.17
, Issue.12
, pp. 1456-1460
-
-
Lentz, K.A.1
Polli, J.W.2
Wring, S.A.3
Humphreys, J.E.4
Polli, J.E.5
-
14
-
-
0031778623
-
Different actions of CCK on pancreatic and gastric growth in the rat: Effect of CCK(A) receptor blockade
-
Varga G, Kisfalvi K, Pelosini I, D'Amato M, Scarpignato C. 1998. Different actions of CCK on pancreatic and gastric growth in the rat: Effect of CCK(A) receptor blockade. Br J Pharmacol 124(3): 435-440.
-
(1998)
Br J Pharmacol
, vol.124
, Issue.3
, pp. 435-440
-
-
Varga, G.1
Kisfalvi, K.2
Pelosini, I.3
D'Amato, M.4
Scarpignato, C.5
-
15
-
-
0034712893
-
Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system
-
Lentz KA, Hayashi J, Lucisano LJ, Polli JE. 2000. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system. Int J Pharm 200(1):41-51.
-
(2000)
Int J Pharm
, vol.200
, Issue.1
, pp. 41-51
-
-
Lentz, K.A.1
Hayashi, J.2
Lucisano, L.J.3
Polli, J.E.4
-
16
-
-
0026722467
-
Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase
-
Sarkadi B, Price EM, Boucher RC, Germann UA, Scarborough GA. 1992. Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. J Biol Chem 267(7):4854-4858.
-
(1992)
J Biol Chem
, vol.267
, Issue.7
, pp. 4854-4858
-
-
Sarkadi, B.1
Price, E.M.2
Boucher, R.C.3
Germann, U.A.4
Scarborough, G.A.5
-
17
-
-
0032562111
-
Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells
-
Huai-Yun H, Secrest DT, Mark KS, et al. 1998. Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells. Biochem Biophys Res Commun 243(3):816-820.
-
(1998)
Biochem Biophys Res Commun
, vol.243
, Issue.3
, pp. 816-820
-
-
Huai-Yun, H.1
Secrest, D.T.2
Mark, K.S.3
-
18
-
-
0035476729
-
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: Effect of polyglutamylation on MTX transport
-
Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD. 2001. Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: Effect of polyglutamylation on MTX transport. Cancer Res 61(19):7225-7232.
-
(2001)
Cancer Res
, vol.61
, Issue.19
, pp. 7225-7232
-
-
Zeng, H.1
Chen, Z.S.2
Belinsky, M.G.3
Rea, P.A.4
Kruh, G.D.5
-
19
-
-
0028080058
-
Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers
-
Adson A, Raub TJ, Burton PS, et al. 1994. Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers. J Pharm Sci 83(11):1529-1536.
-
(1994)
J Pharm Sci
, vol.83
, Issue.11
, pp. 1529-1536
-
-
Adson, A.1
Raub, T.J.2
Burton, P.S.3
-
20
-
-
0035157333
-
Effect of common excipients on Caco-2 transport of low-permeability drugs
-
Rege BD, Yu LX, Hussain AS, Polli JE. 2001. Effect of common excipients on Caco-2 transport of low-permeability drugs. J Pharm Sci 90(11):1776-1786.
-
(2001)
J Pharm Sci
, vol.90
, Issue.11
, pp. 1776-1786
-
-
Rege, B.D.1
Yu, L.X.2
Hussain, A.S.3
Polli, J.E.4
-
21
-
-
0030926727
-
Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets
-
Polli JE, Rekhi GS, Augsburger LL, Shah VP. 1997. Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets. J Pharm Sci 86(6): 690-700.
-
(1997)
J Pharm Sci
, vol.86
, Issue.6
, pp. 690-700
-
-
Polli, J.E.1
Rekhi, G.S.2
Augsburger, L.L.3
Shah, V.P.4
-
22
-
-
0028029150
-
Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism
-
Tsuji A, Takanaga H, Tamai I, Terasaki T. 1994. Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm Res 11(1):30-37.
-
(1994)
Pharm Res
, vol.11
, Issue.1
, pp. 30-37
-
-
Tsuji, A.1
Takanaga, H.2
Tamai, I.3
Terasaki, T.4
-
23
-
-
0036293772
-
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
-
Tang F, Horie K, Borchardt RT. 2002. Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res 19(6):765-772.
-
(2002)
Pharm Res
, vol.19
, Issue.6
, pp. 765-772
-
-
Tang, F.1
Horie, K.2
Borchardt, R.T.3
-
24
-
-
0031687181
-
Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers
-
Zhang Y, Benet LZ. 1998. Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers. Pharm Res 15(10):1520-1524.
-
(1998)
Pharm Res
, vol.15
, Issue.10
, pp. 1520-1524
-
-
Zhang, Y.1
Benet, L.Z.2
-
25
-
-
0036166635
-
Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2)
-
Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. 2002. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology 64(3):126-134.
-
(2002)
Pharmacology
, vol.64
, Issue.3
, pp. 126-134
-
-
Flanagan, S.D.1
Cummins, C.L.2
Susanto, M.3
Liu, X.4
Takahashi, L.H.5
Benet, L.Z.6
-
26
-
-
0029916534
-
P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
-
Schuetz EG, Schinkel AH, Relling MV, Schuetz JD. 1996. P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc Natl Acad Sci USA 93(9):4001-4005.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.9
, pp. 4001-4005
-
-
Schuetz, E.G.1
Schinkel, A.H.2
Relling, M.V.3
Schuetz, J.D.4
-
27
-
-
0034947674
-
From MDR to MXR: New understanding of multidrug resistance systems, their properties and clinical significance
-
Litman T, Druley TE, Stein WD, Bates SE. 2001. From MDR to MXR: New understanding of multidrug resistance systems, their properties and clinical significance. Cell Mol Life Sci 58(7):931-959.
-
(2001)
Cell Mol Life Sci
, vol.58
, Issue.7
, pp. 931-959
-
-
Litman, T.1
Druley, T.E.2
Stein, W.D.3
Bates, S.E.4
-
28
-
-
0032748841
-
In vitro transepithelial drug transport by on-line measurement: Cellular control of paracellular and transcellular transport
-
Wielinga PR, de Waal E, Westerhoff HV, Lankelma J. 1999. In vitro transepithelial drug transport by on-line measurement: Cellular control of paracellular and transcellular transport. J Pharm Sci 88(12):1340-1347.
-
(1999)
J Pharm Sci
, vol.88
, Issue.12
, pp. 1340-1347
-
-
Wielinga, P.R.1
De Waal, E.2
Westerhoff, H.V.3
Lankelma, J.4
-
29
-
-
0029157072
-
Expression pattern of MRP in human tissues and adult solid tumor cell lines
-
Kruh GD, Gaughan KT, Godwin A, Chan A. 1995. Expression pattern of MRP in human tissues and adult solid tumor cell lines. J Natl Cancer Inst 87(16):1256-1258.
-
(1995)
J Natl Cancer Inst
, vol.87
, Issue.16
, pp. 1256-1258
-
-
Kruh, G.D.1
Gaughan, K.T.2
Godwin, A.3
Chan, A.4
-
30
-
-
0036251597
-
Pharmacokinetics of dexloxiglumide after administration of single and repeat oral escalating doses in healthy young males
-
Persiani S, Damato M, Makovec F, Tavares IA, Bishai PM, Rovati LC. 2002. Pharmacokinetics of dexloxiglumide after administration of single and repeat oral escalating doses in healthy young males. Int J Clin Pharmacol Ther 40(5):198-206.
-
(2002)
Int J Clin Pharmacol Ther
, vol.40
, Issue.5
, pp. 198-206
-
-
Persiani, S.1
Damato, M.2
Makovec, F.3
Tavares, I.A.4
Bishai, P.M.5
Rovati, L.C.6
-
31
-
-
10744222974
-
Pharmacokinetics and metabolism of the cholecystokinin antagonist dexloxiglumide in male human volunteers
-
Webber C, Roth A, Persiani S, et al. Pharmacokinetics and metabolism of the cholecystokinin antagonist dexloxiglumide in male human volunteers. Xenobiotica 33(6):625-641.
-
Xenobiotica
, vol.33
, Issue.6
, pp. 625-641
-
-
Webber, C.1
Roth, A.2
Persiani, S.3
-
32
-
-
0005453279
-
Phase I Metabolism of Dexloxiglumide (CR 2017) by Human Liver Microsomes
-
Hall M, Cheung Y, Matthews A, et al. 2001. Phase I Metabolism of Dexloxiglumide (CR 2017) by Human Liver Microsomes. Drug Metab Rev 33(Suppl 1):91.
-
(2001)
Drug Metab Rev
, vol.33
, Issue.SUPPL. 1
, pp. 91
-
-
Hall, M.1
Cheung, Y.2
Matthews, A.3
-
33
-
-
0028948839
-
A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
-
Amidon GL, Lennernas H, Shah VP, Crison JR. 1995. A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12(3):413-420.
-
(1995)
Pharm Res
, vol.12
, Issue.3
, pp. 413-420
-
-
Amidon, G.L.1
Lennernas, H.2
Shah, V.P.3
Crison, J.R.4
-
34
-
-
12444346800
-
Method Considerations for Caco-2 Permeability Assessment in the Biopharmaceutics Classification System
-
Tolle-Sander S, Polli JE. 2002. Method Considerations for Caco-2 Permeability Assessment in the Biopharmaceutics Classification System. Pharmacopeial Forum, Stimuli to the Revision Process 28(1):164-172.
-
(2002)
Pharmacopeial Forum, Stimuli to the Revision Process
, vol.28
, Issue.1
, pp. 164-172
-
-
Tolle-Sander, S.1
Polli, J.E.2
-
35
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. 2001. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Delivery Rev 46(1-3):3-26.
-
(2001)
Adv Drug Delivery Rev
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
36
-
-
0014126586
-
Correlation of dissolution rate and griseofulvin absorption in man
-
Katchen B, Symchowicz S. 1967. Correlation of dissolution rate and griseofulvin absorption in man. J Pharm Sci 56(9):1108-1111.
-
(1967)
J Pharm Sci
, vol.56
, Issue.9
, pp. 1108-1111
-
-
Katchen, B.1
Symchowicz, S.2
-
37
-
-
0022070123
-
Absorption potential: Estimating the fraction absorbed for orally administered compounds
-
Dressman JB, Amidon GL, Fleisher D. 1985. Absorption potential: Estimating the fraction absorbed for orally administered compounds. J Pharm Sci 74(5):588-589.
-
(1985)
J Pharm Sci
, vol.74
, Issue.5
, pp. 588-589
-
-
Dressman, J.B.1
Amidon, G.L.2
Fleisher, D.3
|