Serum adiponectin levels in women with polycystic ovary syndrome

Human Reproduction

Volumn 18, Issue 9, 2003, Pages 1790-1796

  Panidis, Dimitrios ^a   Kourtis, Anargyros ^a   Farmakiotis, Dimitrios ^a   Mouselech, Tzant ^a   Rousso, David ^a   Koliakos, Georgis ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Adiponectin; Adiposity; Body mass index; Insulin resistance; PCOS

Indexed keywords

ADIPONECTIN; ANDROGEN; ANDROSTENEDIONE; FOLLITROPIN; GLUCOSE; HORMONE; HYDROXYPROGESTERONE; INSULIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROLACTIN; SEX HORMONE BINDING GLOBULIN; STEROID; TESTOSTERONE;

ADOLESCENT; ADULT; ANDROGEN BLOOD LEVEL; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DISEASE ASSOCIATION; FEMALE; FOLLITROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONE ACTION; HORMONE BLOOD LEVEL; HUMAN; HYPERANDROGENISM; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; METABOLIC PARAMETERS; MULTIPLE REGRESSION; OBESITY; OVARY POLYCYSTIC DISEASE; OVULATION; PATHOGENESIS; PROGESTERONE BLOOD LEVEL; PROLACTIN BLOOD LEVEL; PROTEIN BLOOD LEVEL; STEROIDOGENESIS;

FALLOPIA;

EID: 0043265072     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deg353     Document Type: Article

References (38)

1. Adams, J., Polsen, D.W. and Franks, S. (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br. Med. J., 293, 355-359.
2. Adashi, E.Y., Resnick, C.E., D'Ercole, A.J., Svoboda, M.E. and Van Wyk, J.J. (1985) Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr. Rev., 6, 400-420.
3. Ahima, R.S. and Flier, J.S. (2000) Adipose tissue as an endocrine organ. Trends Endocrinol. Metab., 11, 327-332.
4. Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K. and Miyagawa, J. (1999) Paradoxical decrease of an adipose specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun., 257, 79-83.
5. Berg, A.H., Combs, T.P., Du, X., Brownlee, M. and Schere, P.E. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Med., 7, 947-953.
6. Berg, A.H., Combs, T.P. and Scherer, P.E. (2002) ACRP30/Adiponectin: An adipokine regulating glucose and lipid metabolism. Trends Endocrinol. Metab., 13, 84-89.
7. Combs, T.P., Berg, A.H., Rajala, M.W., Klebanov, S., Iyengar, P., Jimenez-Chillaron, J.C., Patti, M.E., Klein, S.L., Weinstein, R.S. and Scherer, P.E. (2003) Sexual differentiation, pregnancy, calorie restriction and aging affect the adipocyte-specific protein adiponectin. Diabetes, 52, 268-276.
8. Costello, M.F. and Eden, J.A. (2003) A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. Fertil. Steril., 79, 1-13.
9. Dunaif, A. (1994) Molecular mechanisms of insulin resistance in the polycystic ovary syndrome. Semin. Reprod. Endocrinol., 12, 15-20.
10. Dunaif, A. (1997) Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis. Endocr. Rev., 18, 774-800.
11. Dunaif, A., Segal, K.R., Futterweit, W. and Dobrjansky, A. (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38, 1165-1174.
12. Ehrmann, D.A., Barnes, R.B., Rosenfield, R.L., Cavaghan, M.K. and Imperial, J. (1999) Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care, 22, 141-146.
13. Franks, S. (1995) Polycystic ovary syndrome. N. Engl. J. Med., 333, 853-861.
14. Futterweit, W. (1999) Polycystic ovary syndrome, clinical perspective and management. Obstet. Gynecol. Surv., 54, 403-413.
15. Homburg, R. (1996) Polycystic ovary syndrome - From gynaecological curiosity to multisystem endocrinopathy. Hum. Reprod., 11, 29-39.
16. Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K. et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol., 20, 1595-1599.
17. Hotta, K., Funahashi, T., Bodkin, N.L., Ortmeyer, H.K., Arita, Y., Hansen, B.C. and Matzuzawa, Y. (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression of type 2 diabetes in rhesus monkeys. Diabetes, 50, 1126-1133.
18. Hull, M.G. (1987) Epidemiology of infertility and polycystic ovarian disease, endocrinological and demographic studies. Gynaecol. Endocrinol., 1, 235-245.
19. Legro, R.S., Finegood, D. and Dunaif, A. (1998) A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 83, 2694-2698.
20. Lindsay, R.S., Funahashi, T., Hanson R.L., Matsuzawa, Y., Tanaka S., Tataranni, P.A., Knowler, W.C. and Krakoff, J. (2002) Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet, 360, 57-58.
21. Nestler, J.E., Powers, L.P., Matt, D.W., Steingold, K.A., Plymate, S.R., Rittmaster, R.S., Clore, J.N., Blackart, D.W. et al. (1991) A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 72, 83-89.
22. Okamoto, Y., Arita, Y., Nishida, M., Muragushi, M., Ouchi, N., Takahashi, M., Igura, T., Inui, Y., Kihara, S., Nakamura, T. et al. (2000) An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Hormone Metab. Res., 32, 47-50.
23. Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T. et al. (1999) Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin. Circulation, 100, 2473-2476.
24. Ouchi, N., Kihara, S., Arita, Y., Nishida, M., Matsuyama, A., Okamoto, Y., Ishigami, M., Kuriyama, H., Kishida, K. et al. (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation, 103, 1057-1063.
25. Pagotto, U., Gambineri, A., Vicennati, V., Heiman, M.L., Tschop, M. and Pasquali, R. (2002) Plasma ghrelin, obesity, and the polycystic ovary syndrome: Correlation with insulin resistance and androgen levels. J. Clin. Endocrinol. Metab., 87, 5625-5629.
26. Panidis, D., Rousso, D., Matalliotakis, I., Kourtis, A., Stamatopoulos, P. and Koumantakis, E. (2000) The influence of long-term administration of conjugated estrogens and antiandrogens to serum leptin levels in women with polycystic ovary syndrome. Gynecol. Endocrinol., 14, 169-172.
27. Philips, S.A., Ciaraldi, T.P., Kong, A.P.S., Bandukwala, R., Aroda, V., Carter, L., Baxi, S., Muduliar, S.R. and Henry, R.R. (2003) Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy. Diabetes, 52, 667-674.
28. Radziuck, J. (2000) Insulin sensitivity and its measurement: Structural commonalities among the methods. J. Clin. Endocrinol. Metab., 85, 4426-4433.
29. Scherer, P.E., Williams, S., Fogliano, M., Baldini, G. and Lodish, H.F. (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem., 270, 26746-26749.
30. Spranger, J., Kroke, A., Mohlig, M., Bergmann, M.M., Ritsow, M., Boeing, H. and Pfeiffer, A.F.H. (2003) Adiponectin and protection against type 2 diabetes mellitus. Lancet, 361, 226-228.
31. Steppan, C.M. and Lazar, M.A. (2002) Resistin and obesity-associated insulin resistance. Trends Endocrinol. Metab., 13, 18-22.
32. Tsao, T.S., Lodish, H.F. and Fruebis, J. (2002) ACRP30, a new hormone controlling fat and glucose metabolism. Eur. J. Pharmacol., 440, 213-221.
33. Tschritter, O., Fritsche, A., Thamer, C., Haap, M., Shirkavand, F., Rahe, S., Staiger, H., Maerker, E., Haring, H. and Stumvoll, M. (2003) Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes, 52, 239-243.
34. Vernon, R.G., Denis, R.G.P. and Sorensen, A. (2001) Signals of adiposity. Domest. Anim. Endocrinol., 21, 197-214.
35. Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matzuzawa, Y. and Pratley, R.E. (2001) Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia. J. Clin. Endocrinol. Metab., 86, 1930-1935.
36. Yamamuchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N, et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Med., 7, 941-946.
37. Zawadski, J.K. and Dunaif, A. (1992) Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach. In Dunaif, A., Givens, J.R., Haseltine, F.P. and Merriam, G.E. (eds), Polycystic Ovary Syndrome. Current Issues in Endocrinology and Metabolism. Blackwell Scientific Publications, Boston, p. 377.
38. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J.M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.