Polycystic ovary syndrome - From gynaecological curiosity to multisystem endocrinopathy

Human Reproduction

Volumn 11, Issue 1, 1996, Pages 29-39

  Homburg, R ^a  

^a Golda Medical Center Israel   (Israel)

Author keywords

GnRHa; Hyperandrogenism; Insulin; Ovulation induction; Polycystic ovary syndrome

Indexed keywords

CLOMIFENE CITRATE; CYPROTERONE ACETATE; ETHINYLESTRADIOL; GONADORELIN DERIVATIVE; GROWTH FACTOR; HUMAN MENOPAUSAL GONADOTROPIN; INSULIN; LUTEINIZING HORMONE; OCTREOTIDE;

ANDROGEN SYNTHESIS; AUTOSOMAL DOMINANT DISORDER; CLINICAL FEATURE; DISEASE COURSE; ENDOCRINE DISEASE; FEMALE; GENETIC DISORDER; HISTORY OF MEDICINE; HUMAN; HYPERANDROGENISM; OVARY INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; REVIEW; TRANSVAGINAL ECHOGRAPHY;

EID: 0030047163     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.humrep.a019031     Document Type: Review

References (123)

1. Aakvaag, A. (1985) Hormonal response to electrocautery of the ovary in patients with polycystic ovarian disease. Br. J Obstet. Gynaecol., 92, 1258-1264.
2. Abdel Gadir, A., Khatim, M.S., Mowafi, R.S., Alnaser, H.M.I., Muharib, N.S and Shaw W. (1992) Implications of ultrasonically diagnosed polycystic ovaries. I. Correlations with basal hormonal profiles Hum. Reprod., 4, 453-457.
3. Abdel Gadir, A., Khatim, M.S., Alnaser, H.M.I., Muwafi, R.S. and Shaw, R.W. (1993) Ovarian electrocautery: responders versus non-responders Gynecol. Endocrinol., 7, 43-48.
4. Acar, B. and Kadanli, S. (1993) Diminished growth hormone responses to L-dopa in polycystic ovarian disease. Fertil. Steril., 60, 984-987.
5. Adams, J., Franks, S., Poison, D.W., Mason, H.D., Abdulwahid, N. et al (1985) Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotrophin releasing hormone. Lancet, ii, 1375-1378.
6. Adams, J., Polson, D.W. and Franks, S (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br. Med. J., 293, 355-359.
7. Adashi, E. Hsueh, A.J.W. and Yen, S.S.C. (1981) Insulin enhancement of luteinizing hormone and follicle stimulating hormone release by cultured pituitary cells. Endocrinology, 108, 1441-1449.
8. Adashi, E.Y., Resnick, C.E., D'Ercole, J., Svoboda, M.E. and Van Wyk, J.J. (1985) Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr. Rev., 6, 400-420.
9. Angervo, M., Koistinen, R., Suikkari, A.M. and Seppala, M. (1991) Insulin-like growth factor binding protein-1 inhibits the DNA amplification induced by insulin-like growth factor-1 in human granulosa-luteal cells. Hum. Reprod., 6, 770-773.
10. Balen, A.H., Tan, S.L. and Jacobs, H.S. (1993a) Hypersecretion of luteinising hormone - a significant cause of infertility and miscarriage. Br. J. Obstet. Gynaecol., 100, 1082-1089.
11. Balen, A.H., Tan, S L., MacDougall, J. and Jacobs, H.S. (1993b) Miscarriage rates following in-vitro fertilisation are increased in women with polycystic ovaries and are reduced by pituitary desensitization with buserelin. Hum. Reprod., 8, 959-964.
12. Barbieri, R.L., Makris, A., Randall, R.W., Daniels, G., Kistner, R.W. and Ryan, K.J. (1986) Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J. Clin. Endocrinol. Metab., 62, 904-910.
13. Barnes, R.B., Rosenfield, R.L., Burstein, S. and Ehrmann, D.A. (1989) Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome. N. Engl. J. Med., 320, 559-565.
14. Bridges, N.A., Cooke, A., Healy, M.J.R., Hindmarsh, P.C. and Brook, C.G.D. (1993) Standards for ovarian volume in childhood and puberty. Fertil. Steril., 60, 456-460.
15. Brown, J.B. (1978) Pituitary control of ovarian function - concepts derived from gonadotrophin therapy. Aust. N.Z. J. Obstet. Gynaecol. 18, 47-54
16. Bunker, C.B., Newton, J., Kilborn, J., Patel, A., Conway, G.S., et al. (1989) Most women with acne have polycystic ovaries. Br. J. Dermatol., 121, 675-680.
17. Burghen, G.A., Givens, J.R. and Kitabchi, A.E. (1980) Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J. Clin. Endocrinol. Metab. 50, 113-116.
18. Buyalos, R.P., Geffner, M.E., Bersch, N., Judd, H L., Watanabe, R.M., Bergman, R.N. and Golde, D.W. (1992) Fertil Steril., 57, 796-803.
19. Cara, J.F., Fan, J., Azzraello, J. and Rosenfield, L.R. (1990) Insulin-like growth factor-1 enhances luteinizing hormone binding capacity to rat ovarian theca-interstitial cells. J. Clin. Invest., 86, 560-565.
20. Cara, J F and Rosenfield, R. (1988) Insulin-like growth factor-1 and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells. Endocrinology, 123, 733-739.
21. Carey, A.H., Chan, K.L., Short, D., White, D., Williamson, R. and Franks, S. (1993) Evidence for a single gene defect causing polycystic ovaries and male pattern baldness. Clin Endocrinol, 38, 653-658.
22. Carey, A.H., Waterworth, D., Patel, K., White, D., Little, J. et al. (1994) Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17. Hum. Mol Gen., 3, 1873-1876.
23. Chereau, A. (1844) Memoires Pour Servir a l'Etude des Maladies des Ovaries. Fortin, Masson and Cie, Paris.
24. Christman, G M., Randolf, J.F., Keich, R.P. and Marshall, J.C. (1991) Reduction of gonadotropin-releasing hormone pulse frequency is associated with subsequent selective follicle stimulating hormone secretion in women with polycystic ovarian disease. J. Clin. Endocrinol. Metab., 72, 1278-1281.
25. Conway, G.S. and Jacobs, H.S. (1993) Clinical implications of hyperinsulinaemia in women. Clin. Endocrinol., 39, 623-632.
26. Conway, G.S., Honour, J.W. and Jacobs, H.S. (1989) Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients. Clin. Endocrinol., 30, 459-470.
27. Conway, G.S., Jacobs, H.S., Holly, J.M P. and Wass, J.A. (1990) Effects of luteinizing hormone, insulin, insulin-like growth factor-1 and insulin-like growth factor small binding protein-1 in the polycystic ovary syndrome. Clin. Endocrinol., 33, 593-603.
28. Conway, G.S., Avey, C. and Rumsby, G. (1994) The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinaemia and polycystic ovary syndrome. Hum. Reprod., 9, 1681-1683.
29. Crowley, W.F., Hall, J.E., Martin, K.A., Adams, J. and Taylor, A.E. (1993) An overview of the diagnostic considerations in polycystic ovarian syndrome. Ann. N.Y. Acad. Sci., 687, 235-241.
30. Dabirashrafi, H., Mohamad, K., Behjatnia, Y. and Moghadami-Tabrizi, N. (1991) Adhesion formation after ovarian electrocauterization on patients with polycystic ovarian syndrome Fertil Steril., 55, 1200-1201.
31. Dahlgren, E., Fnberg, L-G., Johanasson, S., Lindstrom, B., Oden, A., Samsioe, G. (1991) Endometrial carcinoma. Ovarian dysfunction - a risk factor in young women. Eur. J. Obstet. Gynecol. Reprod. Biol., 41, 143-150.
32. Dahlgren, E., Johansson, S., Lindstedt, G., Knuttson, F., Oden, A. et al. (1992) Women with polycystic ovary syndrome wedge resected in 1956-65. A long-term follow-up focusing on natural history and circulating hormones. Fertil. Steril., 57, 505-513.
33. Dale, P.O., Tanbo, T., Djoseland, O., Jervell, J. and Abyholm, T. (1992) Persistence of hyperinsulinemia in polycystic ovary syndrome after ovarian suppression by gonadotropin-releasing hormone agonist. Acta. Endocrinol., 126, 132-136.
34. Dale, PO., Tanbo, T., Lunde, O. and Abyholm, T. (1993) Ovulation induction with low dose follicle stimulating hormone in women with the polycystic ovary syndrome. Acta. Obstet. Cynecol. Scand., 72, 43-46.
35. Daly, D.C., Walters, C.A., Soto-Albors, C.E., Tohan, N. and Riddick, D.H. (1984) A randomized study of dexamethasone in ovulation induction with clomiphene citrate. Fertil. Steril., 41, 844-848.
36. Dewailly, D., Robert, Y., Helin, I., Ardaens, Y., Thomas-Desrousseaux, P. et al (1994) Ovarian stromal hypertrophy in hyperandrogenic women. Clin. Endocrinol., 41, 557-562.
37. Donesky, B.W. and Adashi, E.Y. 1995) Surgically induced ovulation in the polycystic ovary syndrome: wedge resection revisited in the age of laparoscopy. Fertil. Steril., 63, 439-463.
38. Dunaif, A., Segal, K., Futterweit, W. and Dobrjansky, A. (1989) Profound peripheral resistance independent of obesity in polycystic ovary syndrome. Diabetes, 38, 1165-1174.
39. Dunaif, A., Segal, K.R., Green, G., Dobjransky, A. and Licholai, T. (1993) Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes, 41, 1257-1266.
40. Eden, J.A. (1988) Which is the best way to detect the polycystic ovary? Aust. N.Z. J. Obstet. Gynaecol., 28, 221-224.
41. Eden, J.A., Place, J., Carter, G.D., Alaghband-Zadeh, J. and Pawson, M. (1989) Is the polycystic ovary a cause of infertility in the ovulatory woman? Clin. Endocrinol., 30, 77-82.
42. Farhi, J., Homburg, R., Lerner, A. and Ben-Rafael, Z. (1993) The choice of treatment for anovulation following failure to conceive with clomiphene. Hum. Reprod., 8, 1367-1371.
43. Filicori, M., Campaiello, E., Michelacci, L., Pareschi, A., Ferrari, P. et al. (1988) Gonadotropin-releasing hormone (GnRH) analog suppression renders polycystic ovarian disease patients more susceptible to ovulation induction with pulsatile GnRH. J. Clin. Endocrinol. Metab., 66, 327-333.
44. Fleming, R., Haxton, M.J., Hamilton, M.P.R., McCune, G.S., Black, W.P. et al. (1985) Successful treatment of infertile women with oligomenorrhoea using a combination of an LHRH agonist and exogenous gonadotrophins. Br. J. Obstet. Gynaecol., 92, 369-373.
45. Franks, S. (1989) Polycystic ovary syndrome: a changing perspective. Clin. Endocrinol., 31, 87-120.
46. Franks, S. and White, D.M. (1993) Prevalence of and aetiological factors in polycystic ovary syndrome. In Franks, S. and Neuman, F (eds), Polycystic Ovary Syndrome. A New Approach to Treatment. Chester, UK, pp. 19-21.
47. Garcea, N., Campo, S., Panetta, V., Venneri, M., Siccardi, P. et al. (1985) Induction of ovulation with purified urinary follicle stimulating hormone in patients with polycystic ovarian syndrome. Am. J. Obstet. Gynecol., 151, 635-640.
48. Givens, J.R., Anderson, R.N., Wiser, W.L., Umstat, E.S. and Fash, S.A. (1976) The effectiveness of two oral contraceptives in suppressing plasma androstendione, testosterone. LH and FSH, and in stimulating plasma testosterone-binding capacity in hirsute women. Am. J. Obstet. Gynecol., 124, 333-339.
49. Gjonnaess, H. (1984) Polycystic ovarian syndrome treated by ovarian electrocautery through the laparoscope. Fertil. Steril., 41, 20-25.
50. Greenblatt, E.M. and Casper, R.F. (1993) Adhesion formation after laparoscopic ovarian cautery for polycystic ovary syndrome - lack of correlation with pregnancy rate. Fertil. Steril., 60, 766-770.
51. Grulet, H., Hecart, A.C , Delemer, B., Gross, A., Sulmont, V. et al. (1993) Roles of luteinizing hormone and insulin resistance in lean and obese polycystic ovary syndrome. Clin. Endocrinol., 38, 621-626.
52. Gurgan, T., Yarali, H. and Urman, B. (1994) Laparoscopic treatment of polycystic ovarian disease. Hum. Reprod., 9, 573-577.
53. Hague, W.M., Adams, J., Reeders, S.T., Peto, T.E. and Jacobs, H.S. (1988) Familial polycystic ovaries: a genetic disease? Clin. Endocrinol., 29, 593-605.
54. Hamilton-Fairley, D., Kiddy, D., Watson, H., Paterson, C. and Franks, S. (1992) Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin. Br. J Obstet. Gynaecol. 99, 128-131
55. Hamilton-Fairley, D., Kiddy, D., Watson, H., Sagle, M. and Franks, S. (1991) Low dose gonadotrophin therapy for induction of ovulation in 100 women with polycystic ovary syndrome. Hum. Reprod., 6, 1095-1099.
56. Heylen, S.M., Puttemans, P.J. and Brosens, I.A. (1994) Polycystic ovarian disease treated by laparoscopic argon capsule drilling: comparison of vaporization versus performation technique. Hum. Reprod., 9, 1038-1042.
57. Homburg, R. and Jacobs, H.S. (1990) Clinical features of growth hormone action on human ovarian function. Isr. J. Obstet. Gynecol. 1, 114-129.
58. Homburg, R., Armar, N.A., Eshel, A., Adams, J. and Jacobs, H.S (1988a) Influence of serum luteinizing hormone concentrations on ovulation, conception and early pregnancy loss in polycystic ovary syndrome. Br. Med. J. 297, 1024-1026.
59. Homburg, R., Weissglass, L. and Goldman, J. (1988b) Improved treatment for anovulation in polycystic ovarian disease on the inappropriate gonadotrophin release and clomiphene response. Hum. Reprod., 3, 285-288.
60. Homburg, R., Eshel, A., Tucker, M., Mason, P., Adams, J. et al. (1989) One hundred pregnancies following pulsatile luteinising hormone-releasing hormone therapy for ovulation induction. Br. Med. J. 298, 809-812
61. Homburg, R., Eshel, A., Kilborn, J., Adams, J. and Jacobs, H.S. (1990) Combined luteinising hormone-releasing hormone analogue and exogenous gonadotrophins for the treatment of infertility associated with polycystic ovary syndrome. Hum. Reprod., 5, 32-35.
62. Homburg, R., Pariente, C., Lunenfeld, B. and Jacobs, H.S. (1992) The role of insulin-like growth factor-1 (IGF-1) and IGF binding protein-1 (IGF-BP-1) in the pathogenesis of polycystic ovary syndrome. Hum. Reprod., 7, 1379-1383.
63. Homburg, R., Levy, T., Berkovitz, D., Farhi, J., Feldberg, D. et al. (1993a) Gonadotropin-releasing hormone agonist reduces the miscarriage rate for pregnancies achieved in women with polycystic ovary syndrome. Fertil. Steril., 59, 527-531.
64. Homburg, R., Berkovitz, D., Levy, T., Feldberg, D., Ashkenazi, J. and Ben-Rafael, Z. (1993b) In vitro fertilization and embryo transfer for the treatment of infertility associated with polycystic ovary syndrome. Fertil. Steril., 60, 858-863.
65. Homburg, R., Levy, T. and Ben-Rafael, Z. (1995a) A comparative prospective study of conventional regimen with chronic low dose administration of follicle stimulating hormone for anovulation associated with polycystic ovary syndrome. Fertil. Steril., 63, 729-733.
66. Homburg, R., Levy, T. and Ben-Rafael, Z. (1995b) Adjuvant growth hormone for induction of ovulation with gonadotropin releasing-hormone agonist and gonadotropins in polycystic ovary syndrome: a randomized, double-blind, placebo controlled trial. Hum. Reprod., 10, 2550-2553.
67. Howles, C.M., MacNamee, M.C., Edwards, R.G., Goswamy, R. and Steptoe, PC. (1986) Effect of high tonic concentrations of luteinising hormone on outcome of in vitro fertilisation. Lancet. ii, 521-523.
68. Hull, M.G. (1987) Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynaecol Endocrinol. 1, 235-245.
69. Insler, V and Lunenfeld, B. (1991) Pathophysiology of polycystic ovarian disease: new insights. Hum. Reprod., 6, 1025-1029.
70. Insler, V., Shoham, Z., Barash, A., Koistenen, R., Seppala, M., Hen, M., Lunenfeld, B. and Zadik, Z. (1993) Polycystic ovaries in obese and non-obese patients: possible pathophysiological mechanism based on new interpretation of facts and findings. Hum. Reprod., 8, 379-384.
71. Jaatinen, T.A., Antilla, L., Erkkola, R., Koskinen, P., Laippola, P et al (1993) Hormonal responses to physical exercise in patients with polycystic ovary syndrome. Fertil. Steril., 60, 262-267.
72. Kazer, R.R., Kessel, B. and Yen, S.S. (1987) Circulating luteinizing hormone pulse frequency in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 65, 233-6.
73. Khan, C.R., Flier, J.S., Bar, R.S., Archal, J.A. and Gorden, P. (1976) The synehomes of insulin resistance and acanthosis nigricans: Insulin receptor disorders in man. New. Engl. J. Med., 294, 739-745.
74. Kiddy, D.S , Hamilton-Fairley, D., Bush, A., Anyaoku, V., Reed, M.J. and Franks, S. (1992) Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin. Endocrinol., 36, 105-111.
75. Kovacs, G , Buckler, H , Bangah, M., Outch, K., Burger, H., Healy, D. (1991) Treatment of anovulation due to polycystic ovarian syndrome by laparoscopic ovarian electrocautery. Br. J. Obstet. Gynaecol., 98, 30-35.
76. Lanzone, A., Fulghesu, A.M., Guido, M., Ciampelli, M., Caruso, A. and Mancuso, S. (1994) Differential androgen response to adrenocorticotrophin hormone stimulation and effect of opioid antagonist on insulin secretion in polycystic ovary syndrome. Hum. Reprod., 9, 2342-2349.
77. MacDougall, M.J., Tan, S.L., Balen, A. and Jacobs, H.S. (1993) A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization. Hum. Reprod., 8, 233-237.
78. Mason, H.D., Margara, R., Winston, R.M., Beard, R.W., Reed, M.J. and Franks, S. (1990) Inhibition of oestradiol production by epidermal growth factor in human granulosa cells of normal and polycystic ovaries Clin. Endocrinol., 33, 511-517.
79. McFaul, P.B , Traub, A.I. and Thompson, W. (1990) Treatment of clomiphene citrate resistant polycystic ovary syndrome with pure follicle stimulating hormone or human menopausal gonadotropin. Fertil. Steril., 53, 792-797.
80. McLachlan, R.I., Robertson, D.M., Healy, D.L., Burger, H.G. and deKretser, DM. (1987) Circulating immunoreactive inhibin concentrations during the normal human menstrual cycle. J. Clin. Endocrinol. Metab., 65, 954-957.
81. Messinis, J.E. and Templeton, A. (1990) In vivo bioactivity of gonadotrophin surge attenuating factor (GnSAF). Clin. Endocrinol., 33, 213-218.
82. Naether, O.G., Fischer, R., Weise, H.C., Geiger Kotzler, L., Delfs, T and Rudolf, K. (1993) Laparoscopic electrocoagulation of the ovarian surface in infertile patients with polycystic ovarian disease. Fertil. Steril., 60, 88-94.
83. Naether, O.G.J., Baukloh, V., Fishcher, R. and Kowalczyk, T. (1994) Long term follow-up in 206 infertility patients with polycystic ovary syndrome after laparoscopic electrocautery of the ovarian surface. Hum. Reprod , 9, 2342-2349.
84. Nestler, J.E. Barlascini, C.O., Matt, D.W. Steingold, K.A., Plymate, S R., Clore, J.N. and Blackard, W.G. (1989) Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 68, 1027-1032.
85. Ovesen, P., Moller, J., Moller, N. Christiansen, J.S., Jorgenson, J.O.L. and Orskov, H. (1992) Growth hormone secretory capacity and serum insulin-like growth factor-1 levels in primary infertile anovulatory women with regular menses. Fertil. Steril., 57, 97-101.
86. Plymate, S.R., Matej, L.A., Jones, R.E. and Friedl, K.E. (1988) Inhibition of sex hormone binding globulin in the human hepatoma (HepG2) cell line by insulin and prolactin. J Clin. Endocrinol. Metab., 67, 460-464.
87. Polson, D.W., Adams, J., Steer, P.J. and Franks, S. (1986) Unilateral polycystic ovary, Case report. Br. J. Obstet. Gynaecol., 93, 1100-1113.
88. Polson, D.W., Mason, H.D., Saldahna, M.B. and Franks, S. (1987) Ovulation of a single dominant follicle during treatment with low dose pulsatile follicle stimulating hormone in women with polycystic ovary syndrome Clin. Endocrinol., 26, 205-212.
89. Polson, D.W., Adams, J., Wadsworth, J. and Franks, S. (1988) Polycystic ovaries - a common finding in normal women. Lancet 1, 870-872.
90. Poretsky, L., Grigorescu, F., Seibel, M., Moses, A.C. and Flier, S. (1985) Distribution and characterization of insulin and insulin-like growth factor-1 receptors in normal human ovary. J. Clin. Endocrinol Metab., 61, 728-734.
91. Prelevic, G.M., Ginsburg, J., Maletic, D., Hardiman, P., Okolo, S. et al. (1985) The effects of somatostatin analogue octreotide on ovulatory performance in women with polycystic ovaries. Hum. Reprod., 10, 28-32.
92. Prelevic, G.M., Wurzburger, M.I. and Balint-Peric, L. (1989) Effects of a low dose estrogen-antiandrogen combination (Diane-35) on clinical signs of androgenization, hormone profile and ovarian size in patients with polycystic ovary syndrome. Gvnecol. Endocrinol., 3, 269-280
93. Prelevic, G.M., Wurzburger, M.I., Balint-Peric, L. and Nesic, J.S. (1990) Inhibitory effect of sandostatin on secretion of luteinising hormone and ovarian steroids in polycystic ovary syndrome. Lancet. 336, 900-903.
94. Prelevic, G M., Wurzburger, M.I., Balaint-Peric, L. and Ginsburg, J. (1992) Twenty-four h serum growth hormone, insulin, c-peptide. and blood glucose profiles and serum insulin-like growth factor-1 concentrations in women with polycystic ovaries. Horm. Res., 37, 125-131.
95. Quigley, M.E., Rakoff, J.S and Yen, S.S. (1981) Increased luteinizing hormone sensitivity to dopamine inhibition in the polycystic ovary syndrome. J. Clin Endocrinol Metab., 52, 231-234.
96. Rebar, R., Judd, H.L., Yen, S.C.C , Rakoff, J., Vandenberg, G. and Naftolin, F. (1976) Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin. Invest., 57, 1320-1329.
97. Regan, L., Owen, E.J. and Jacobs, HS. (1990) Hypersecretion of luteinising hormone, infertility and miscarriage. Lancet 336, 1141-1144.
98. Robinson, S., Kiddy, D., Gelding, S.V, Willis, D., Niththyanathan, R. et al. (1993) The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenaemia and polycystic ovaries. Clin. Endocrinol., 39, 351-355.
99. Rosenfield, R L., Barnes, R.B., Cara, J.F. and Lucky, AW. (1990) Dysregulation of cytochrome P450c 17 alpha as the cause of polycystic ovary syndrome. Fertil. Steril., 53, 785-791.
100. Sagle, M., Bishop, K., Ridley, N., Alexander, F.M., Michel, M et al. (1988) Recurrent early miscarriage and polycystic ovaries. Br. Med. J., 297, 1027-1028.
101. Saxton, D.W , Farquhar, C.M., Rae, T., Beard, R.W., Anderson, M.C. and Wadsworth, J. (1990) Accuracy of ultrasound measurements of female pelvic organs. Br. J Obstet. Gynaecol., 97, 695-699.
102. Schachter, M., Balen, A.H., Patel, A. and Jacobs, H.S. (1995). Hypogonadotrophic patients with ultrasonographically detected polycystic ovaries have aberrant gonadotropin secretion when treated with pulsatile gonadotropin releasing hormone - a new insight to the pathophysiology of polycystic ovary syndrome. Fertil. Steril. (in press).
103. Scheele, F., Hompes, P.G A , Van der Meer, M., Schoute, E. and Schoemaker, J. (1993a) The effects of a gonadotrophin-releasing hormone-agonist on treatment with low dose follicle stimulating hormone in polycystic ovary syndrome. Hum. Reprod., 8, 699-704.
104. Scheele, F., Hompes, P.G.A., Van der Meer, M., Schoute, E. and Schoemaker, J. (1993b) The relationship between FSH dose and FSH level and its relevance for ovulation induction with adjuvant gonadotropin-releasing hormone-agonist treatment. Fertil. Steril., 60, 620-625.
105. Seibel, M.M., Kamrava, M.M., McArdle, C. and Taymor, M.L. (1984) Treatment of polycystic ovarian disease with chronic low dose follicle stimulating hormone, biochemical changes and ultrasound correlation. Int. J. Fertil., 29, 39-43.
106. Shaw, R.W. (1989) Use of nafarelin to investigate the pathophysiology of the polycystic ovary syndrome. J. Reprod. Med., 34, 1039-1043.
107. Shoham, Z., Borenstein, R., Lunenfeld, B. and Pariente, C. (1990a) Hormonal profiles following clomiphene citrate therapy in conception and non-conception cycles. Clin. Endocrinol., 33, 271-278.
108. Shoham, Z., Homburg, R. and Jacobs, H.S. (1990b) Induction of ovulation with pulsatile LHRH. Ball. Clin. Obstet. Gynecol., 4, 589-608.
109. Shoham, Z., Patel, A. and Jacobs, HS. (1991) Polycystic ovary syndrome: safety and effectiveness of stepwise and low dose administration of purified follicle stimulating hormone. Fertil. Steril., 55, 1051-1056.
110. Shoham, Z., Conway, G.S., Patel, A. and Jacobs, H.S. (1992) Polycystic ovaries in patients with hypogonadotropic hypogonadism: similarity of ovarian response to gonadotropin stimulation in patients with polycystic ovary syndrome. Fertil. Steril., 58, 37-45.
111. Sopelak, V.M. and Hodgen, G.D. (1984) Blockade of the estrogen-induced luteinizing hormone surge in monkeys: a nonsteroidal, antigenic factor in porcine follicular fluid. Fertil. Steril., 41, 108-113.
112. Stanger, J.D. and Yovich, J.L. (1985) Reduced in-vitro fertilisation of human oocytes from patients with raised basal luteinising hormone levels during the follicular phase. Br. J. Obstet. Gynaecol., 92, 385-393.
113. Stein, I.F. and Leventhal, M.L. (1935) Amenorrhea associated with bilateral polycystic ovaries. Am. J Obstet. Gynecol., 29, 181-191.
114. Stephens, J., Carey, A.M., Short, R. Williamson, R. and Franks, S. (1993) Premature balding, the male phenotype of polycystic ovaries. J. Endocrinol., 139, 31.
115. Suikkari, A.M , Koivisto, V.A., Rutanen, E.M., Yki-Larvinen, H., Karonen, S.L and Seppala, M. (1988) Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein. J. Clin. Endocrinol. Metab., 66, 266-272.
116. Swanson, M , Sauerbrie, E.E. and Cooperberg, P.L. (1981) Medical implications of ultrasonically detected polycystic ovaries. J Clin. Ultrasound, 9, 219-222.
117. Tapanainen, J., Ronnberg, L., Martikainen, H., Reinila, M., Koistenen, R. and Seppala, M. (1991) Short and long-term effects of growth hormone on circulating levels of insulin-like growth factor-1 (IGF-1), IGF-1 binding protein-1 and insulin: a placebo controlled study. J. Clin. Endocrinol. Metab., 73, 71-74.
118. Trounson, A., Wood, C. and Kausche, A. (1994) In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil. Steril., 62, 353-362.
119. Vaitukaitis, J.L. (1983) Polycystic ovary syndrome: what is it? N. Engl. J. Med., 309, 1245-1246.
120. Van den Berg, G. and Yen, S.S.C. (1973) Effect of anti-estrogenic action of clomiphene during the menstrual cycle: evidence for a change in the feedback sensitivity. J. Clin. Endocrinol. Metab., 37, 356-365.
121. Van der Meer, M., Hompes, P.G.A., Scheele, F, Schoute, E., Veersema, S. and Schoemaker, J. (1994) Follicle stimulating hormone (FSH) dynamics of low dose step-up ovulation induction with FSH in patients with polycystic ovary syndrome. Hum. Reprod., 9, 1612-1617.
122. Velaquez, E.M., Mendoza, S., Hamer, T, Sosa, F. and Glueck, C.J. (1994) Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure while facilitating normal menses and pregnancy. Metabolism, 43, 647-654.
123. Wang, C.F. and Gemzell, C. (1980) The use of human gonadotropin for the induction of ovulation in women with polycystic ovarian disease. Fertil. Steril , 33, 479-486.