Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: Role of NO and the AT2 receptor

Journal of Hypertension

Volumn 21, Issue 8, 2003, Pages 1531-1538

  Červenka, Luděk ^a,b   Vaněčková, Ivana ^a,b   Malý, Jan ^b   Horáček, Vladislav ^a,b   El Dahr, Samir S ^b  

^a INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin AT2 receptors; Bradykinin B2 receptors; Goldblatt hypertension; Kallikrein kinin system; Nitric oxide; One clip; Two kidney

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; BRADYKININ B2 RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CLAMP; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; ENDOTHELIUM CELL; GENE INACTIVATION; HYPERTENSION; LONG TERM EXPOSURE; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENOVASCULAR HYPERTENSION; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; WILD TYPE; ANIMAL; BLOOD PRESSURE; C57BL MOUSE; DRUG ANTAGONISM; GENETICS; HEART MUSCLE; KIDNEY; METABOLISM; MOUSE MUTANT; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; SURGICAL INSTRUMENT;

ANIMALS; BLOOD PRESSURE; HYPERTENSION, RENAL; KIDNEY; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORGAN SIZE; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTOR, BRADYKININ B2; SURGICAL INSTRUMENTS;

EID: 0043239169     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200308000-00018     Document Type: Article

References (46)

1. Navar LG, Zou L, Thun A Von, Wang CT, Imig JD, Mitchell KD. Unraveling the mystery of Goldblatt hypertension. News Physiol Sci 1998; 13:170-176.
2. Carretero OA, Scicli AG. The kallikrein-kinin system as a regulator of cardiovascular and renal function. In: Laragh JH., Brenner BM (editors): Hypertension, pathophysiology, diagnosis, and management, 2nd edn. New York: Raven Press; 1995, pp. 983-999.
3. Schmaier AH. The plasma kallikrein-kinin system counterbalances the renin-angiotensin system. J Clin Invest 2002; 109:1007-1009.
4. Tschope C, Schultheiss HP, Walther T. Multiple interactions between the renin-angiotensin and the kallikrein-kinin systems: role of ACE inhibition and AT1 receptor blockade. J Cardiovasc Pharm 2002; 39:478-487.
5. Madeddu P, Emanueli C. Bradykinin receptors and the development of hypertension. In: McCarty R, Blizard DA, Chevalier RL (editors): Handbook of hypertension, development of the hypertensive phenotype: basic and clinical studies. Vol. 19, 1st edn. Amsterdam: Elsevier Science; 1999, pp. 359-382.
6. Madeddu P, Parpaglia PP, Demontis MV, Varoni MV, Fattaccio MC, Glorioso N. Chronic inhibition of bradykinin B2-receptors enhances the slow vasopressor response to angiotensin II. Hypertension 1993; 23:646-652.
7. Majima M, Mizogami S, Kuribayashi Y, Katori M, Ohishi S. Hypertension induced by a nonpressor dose of angiotensin II in kininogen-deficient rats. Hypertension 1993; 24:111-119.
8. Rhaleb NE, Yang XP, Nanba M, Shesely EG, Carretero OA. Effect of chronic blockade of the kallikrein-kinin system on the development of hypertension in rats. Hypertension 2001; 37:121-128.
9. Pasquié JL, Herizi A, Jover B, Mimran A. Chronic bradykinin infusion and receptor blockade in angiotensin II hypertension in rats. Hypertension 1999; 33:830-834.
10. Alfie ME, Sigmon DH, Pomposiello SI, Carretero OA. Effect of high salt intake in mutant mice lacking bradykinin B2 receptors. Hypertension 1997; 29:483-487.
11. Cervenka L, Harrison-Bernard LM, Dipp S, Primrose G, Imig JD, El-Dahr SS. Early onset salt-sensitive hypertension in bradykinin B2 receptor null mice. Hypertension 1999; 34:176-180.
12. Navar LG, Ichihara A, Chin SY, Imig JD. Nitric oxide-angiotensin II interactions in angiotensin II-dependent hypertension. Acta Physiol Scand 2000; 168:139-147.
13. Cervenka L, Malý J, Karasová L, Šimová M, Vítko Š, Hellerová S, et al. Angiotensin II-induced hypertension in bradykinin B2 receptor knockout mice. Hypertension 2001; 37:967-973.
14. Carey RM, Jin XH, Siragy HM. Role of the angiotensin AT2 receptor in blood pressure regulation and therapeutic implications. Am J Hypertens 2001; 14:S98-S102.
15. Blume A, Kaschina E, Unger T. Angiotensin II type 2 receptors: signaling and pathophysiological role. Curr Opin Nephrol Hypertens 2001; 10:239-246.
16. Tsutsumi Y, Matsubara H, Masaki H, Kurihara H, Murasawa S, Takai S, et al. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilatation. J Clin Invest 1999; 104:925-935.
17. Wiemer G, Scholkens BA, Wagner A, Heitsch H, Linz W. The possible role of angiotensin II subtype AT2 receptors in endothelial cells and isolated ischemic rat hearts. J Hypertens 1993; 5:S234-S235.
18. Liu YH, Yang XP, Sharov VG, Nass O, Sabbah HN, Peterson E, Carretero OA. Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors. J Clin Invest 1997; 99:1926-1935.
19. Siragy HM, Jaffa AA, Margolius HS, Carey RM. Renin-angiotensin system modulates renal bradykinin production. Am J Physiol 1996; 271: R1090-R1095.
20. Borkowski JA, Ransom RW, Seabrook GR, Trumbauer M, Chen H, Hill RG, et al. Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem 1995; 270:13706-13710.
21. Wiesel P, Mazzolai L, Nussberger J, Pedrazzini T. Two-kidney, one clip and one-kidney, one clip hypertension in mice. Hypertension 1997; 29:1025-1030.
22. Levy BI, Benessiano J, Henrion D, Caputo L, Heymes C, Duriez M, et al. Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. J Clin Invest 1996; 98:418-425.
23. Li J-S, Touyz RM, Schiffrin EL. Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats. Hypertension 1998; 31:487-492.
24. Macari D, Whitebread S, Cumin F, DeGasparo M, Levens N. Renal actions of the angiotensin AT2 receptor ligands CGP 42112 and PD 123319 after blockade of the renin-angiotensin system. Eur J Pharm 1994; 259:27-36.
25. Liu KL, Lo M, Grouzmann E, Mutter M, Sassard J. The subtype 2 of angiotensin II receptors and pressure-natriuresis in adult rat kidneys. Br J Pharm 1999; 126:626-832.
26. Madeddu P, Milia AF, Salis MB, Gaspa L, Gross W, Lippoldt A, Emanueli C. Renovascular hypertension in bradykinin B2-receptor knockout mice. Hypertension 1998; 32:503-509.
27. El-Dahr SS, Dipp S, Guan S, Navar LG. Renin, angiotensinogen, and kallikrein gene expression in two-kidney Goldblatt hypertensive rats. Am J Hypertens 1993; 6:914-919.
28. Albertini R, Rosas R, Croxatto HR, Roblero J. Kallikrein-kinin system in one- and two-kidney Goldblatt hypertensive rats. Clin Sci 1979; 56:227-233.
29. Navar LG, Thun AM Von, Zou L, El-Dahr SS, Mitchell KD. Enhancement of intrarenal angiotensin II levels in 2 kidney 1 clip and angiotensin II induced hypertension. Blood Pres 1995; 4:88-92.
30. Tornel J, Madrid MI, Garcia-Salamon M, Wirth KJ, Fenoy FJ. Role of kinins in the control of renal papillary blood flow, pressure natriuresis, and arterial pressure. Circ Res 2000; 86:23-28.
31. Trabold F, Pons S, Hagege AA, Bloch-Faure M, Alhenc-Gelas F, Giudicelli JF, et al. Cardiovascular phenotypes of kinin B2 receptor and tissue kallikrein-deficient mice. Hypertension 2002; 40:90-95.
32. Madeddu P, Varoni MV, Palomba D, Emanueli C, Demontis MP, Glorioso N, et al. Anania versus cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation 1997; 96:3570-3578.
33. Carey RM, Howell NL, Jin XH, Siragy HM. Angiotensin type 2 receptor-mediated hypotension in angiotensin type 1 receptor-blocked rats. Hypertension 2001; 38:1272-1277.
34. Siragy HM, Carey RM. Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model. Hypertension 1999; 33:1237-1242.
35. Siragy HM, Inagami T, Ichiki T, Carey RM. Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor. Proc Nat Acad Sci USA 1999; 96:6505-6510.
36. Moore AF, Heiderstadt NT, Huang E, Howell NL, Wang ZQ, Siragy HM, Carey RM. Selective inhibition of the renal angiotensin type 2 receptor increases blood pressure in conscious rats. Hypertension 2001; 37:1285-1291.
37. Zelezna B, Veselsky L, Velek J, Dobesova Z, Zicha J, Kunes J. Influence of active immunization against angiotensin AT1 and AT2 receptor on hypertension development in young and adult SHR. Physiol Res 1999; 48:259-265.
38. Schuijt MP, Vries R, Saxena PR, Danser AHJ. No vasoactive role of the angiotensin II type 2 receptor in normotensive Wistar rats. J Hypertens 1999; 17:1879-1884.
39. Widdop RE, Matrougui K, Levy BI, Henrion D. AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade. Hypertension 2002; 40:516-520.
40. Li Z, Iwai M, Wu L, Shiuchi T, Jinno T, Cui T-X, Horiuchi M. Role of AT2 receptor in the brain in regulation of blood pressure and water intake. Am J Physiol 2003; 284:H116-H121.
41. Cervenka L, Mitchell KD, Oliverio MI, Coffman TM, Navar LG. Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions. Kidney Int 1999; 56:1855-1862.
42. Cervenka L, Horácek V, Vanecková I, Hubácek JA, Oliverio MI, Coffman TM, Navar LG. Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension 2002; 40:735-741.
43. Milia AF, Gross V, Plehm R, Sivla JA De, Bader M, Luft FC. Normal blood pressure and renal function in mice lacking the bradykinin B2 receptor. Hypertension 2001; 37:1473-1479.
44. Rhaleb NE, Peng H, Alfie ME, Shesely EG, Carretero OA. Effect of ACE inhibitor on DOCA-salt- and aortic coarctation-induced hypertension in mice. Do kinin B2 receptors play a role? Hypertension 1999; 33:329-334.
45. Majima M, Katori M, Madeddu P, Rhaleb NE, Yang XP, Carretero OA. Effects of chronic blockade of the kallikrein-kinin system on the development of hypertension in rats. Role of kinins in blood pressure regulation: reality or fiction. Hypertension 2001; 38:e21-e23.
46. Sanford LP, Kallapur S, Ormsby I, Doetschman T. Influence of genetic background on knockout mouse phenotypes. Methods Mol Biol 2001; 158:217-225.