Renal function in the AT(1A) receptor knockout mouse during normal and volume-expanded conditions

Kidney International

Volumn 56, Issue 5, 1999, Pages 1855-1862

  Cervenka, Ludek ^a,b   Mitchell, Kenneth D ^a,b   Oliverio, Michael I ^a,b   Coffman, Thomas M ^a,b   Navar, L Gabriel ^a,b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

Angiotensin II; Extracellular volume; Glomerular filtration rate; Glomerulotubular balance; Renin angiotensin system

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; SODIUM;

ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXTRACELLULAR SPACE; GLOMERULUS FILTRATION RATE; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY FUNCTION; KIDNEY PLASMA FLOW; KNOCKOUT MOUSE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM EXCRETION; ANIMAL; BLOOD; BLOOD PRESSURE; C57BL MOUSE; GENETICS; KIDNEY; KIDNEY CIRCULATION; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; EXTRACELLULAR SPACE; GLOMERULAR FILTRATION RATE; KIDNEY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; RENAL CIRCULATION; SODIUM;

EID: 0032589973     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.00757.x     Document Type: Article

References (35)

1. 1. MITCHELL KD, NAVAR LG: Intrarenal actions of angiotensin II in the pathogenesis of experimental hypertension, in Hypertension, Pathophysiology, Diagnosis, and Management (2nd ed), edited by LARAGH JH, BRENNER BM, New York, Raven Press, 1995, pp 1437-1449
2. 2. TIMMERMANS P, WONG P, CHIU A, HERBLIN W, BENFIELD P, CARINI D, LEE R: WEXLER R, SAYE J, SMITH R: Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 45:205-251, 1993
3. 3. GRIENDLING KK, LASSEGUE B, ALEXANDER RW: Angiotensin receptors and their therapeutic implications. Annu Rev Pharmacol Toxicol 36:281-306, 1996
4. 4. ITO M, OLIVERIO MI, MANNON P, BEST C, MAEDA N, SMITHIES O, COFFMAN TM: Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci USA 92:3521-3525, 1995
5. 1A receptors for angiotensin II. Am J Physiol 274(Renal Physiol 43):F43-F50, 1998
6. 1B receptors in blood pressure regulation. Am J Physiol 272(Renal Physiol 41 ):F515-F520, 1997
7. 1A receptor-deficient mice. Am J Physiol 273(Renal Physiol 42):F315-F320, 1997
8. 8. SCHNERMANN J: Juxtaglomerular cell complex in the regulation of renal salt excretion. Am J Physiol 274(Regul Integr Comp Physiol 43):R263-R279, 1998
9. 9. NAVAR LG: Integrating multiple paracrine regulators of renal microvascular dynamics. Am J Physiol 274(Renal Physiol 43):F433-F444, 1998
10. 10. GUYTON AC: Blood pressure control: Special role of the kidneys and body fluids. Science 252:1813-1816, 1991
11. 11. COWLEY AW JR: Long-term control of arterial blood pressure. Physiol Rev 72:231-300, 1992
12. 1 receptor in adult rat kidney using a monoclonal antibody. Am J Physiol 273(Renal, Fluid Electrol Physiol 41):F170-F177, 1997
13. 13. HARRIS PJ, ZHOU J, SKINNER SL: Effect of angiotensin II and III on glomerulotubular balance in rats. Clin Exp Pharmacol Physiol 14:489-502, 1987
14. 14. LIU FY, COGAN MG: Role of angiotensin II in glomerulotubular balance. Am J Physiol 259(Renal Fluid Electrol Physiol 41):F72-F79, 1990
15. 15. CAMPBELL DJ, LAWRENCE AC, TOWRIE A, KLADIS A, VALENTIJN AJ: Differential regulation of angiotensin peptide levels in plasma and kidney of the rat. Hypertension 18:763-773, 1991
16. 16. Zou LX, IMIG JD, VON THUN AM, HYMEL A, ONO H, NAVAR LG: Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats. Hypertension 28:669-677, 1996
17. 17. BOER WH, BRAAM B, FRANSEN R, BOER P, KOOMANS HA: Effects of reduced renal perfusion pressure and acute, expansion on proximal tubule and whole kidney angiotensin II content in the rat. Kidney Int 51:44-49, 1997
18. 1 receptor. Am J Hypertens 11:570-578, 1998
19. 19. MITCHELL KD, MULLINS JJ: Ang II dependence of tubuloglomerular feedback responsiveness in hypertensive ren-2 transgenic rats. Am J Physiol 268(Renal Fluid Electrol Physiol 37):F821-F828, 1995
20. 20. FOX J, GUAN S, HYMEL, A, NAVAR LG: Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats. Am Physiol 262(Renal Fluid Electrol Physiol 31):F902-F909, 1992
21. 21. NAVAR LG, LEWIS L, HYMEL A, BRAAM B, MITCHELL KD: Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats. J Am Soc Nephrol 5:1153-1158, 1994
22. 22. MITCHELL KD, JACINTO SM, MULLINS JJ: Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol 273(Renal Fluid Electrol Physiol 42):F246-F253, 1997
23. 23. NESHIMURA H, MATSUSAKA T, FOGO A, KON V, ICHIKAWA I: A novel in vivo mechanism for angiotensin type 1 receptor regulation. Kidney Int 52:345-355, 1997
24. 24. NAVAR LG: The kidney in blood pressure regulation and development of hypertension. Med Clin North Am 81:1165-1198, 1997
25. 25. OKUBO S, NIMURA F, MATSUSAKA T, FOGO A, HOGAN BLM, ICHIKAWA I: Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. Kidney Int 53:617-625, 1998
26. 26. KIHARA M, UMEMURA S, SUMIDA Y, YOKOYAMA N, YABANA M, NYUI N, TAMURA K, MURAKAMI K, FUKAMIZU A, ISHII M: Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int 53:548-555, 1998
27. 27. NIJMURA F, LABOSKY P, KAKUCHI J, OKUBA S, YOSHIDA H, OIKAWA T, ICHIKI T, NAFTILAN A, FOGO A, INAGAMI T, HOGAN B, ICHIKAWA I: Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest 66:2947-2954, 1995
28. 28. ESTHER C, MARINO E, HOWARD T, MACHAUD A, CORVOL P, CAPECCHI M, BERNSTEIN K: The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest 99:2375-2385, 1997
29. 1A receptor-deficient mice. Hypertension 31:1171-1177, 1998
30. 30. TSUCHIDA S, MATSUSAKA T, CHEN X, OKUBO S, NIJMURA F, NISHIMURA H, FOGO A, UTSUNOMIYA H, INAGAMI T, ICHIKAWA I: Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest 101:755-760, 1998
31. 1B receptors for angiotensin II. Proc Natl Acad Sci USA 95:15496-15501, 1998
32. 32. NAVAR LG, HARRISON-BERNARD LM, WANG C-T, CERVENKA L, MITCHELL KD: Concentrations and actions of intraluminal angiotensin II. J Am Soc Nephrol 10(Suppl):S189-S195, 1999
33. 33. KIHARA M, UMEMURA S, SUGAYA T, TOYA Y, YABANA M, KOBAYASHI S, TAMURA K, KADOTA T, KISHIDA R, MURAKAMI K, FUKAMIZU A, ISHII M: Expression of neuronal type nitric oxide synthase and renin in the juxtaglomerular apparatus of angiotensin type-1a receptor gene-knockout mice. Kidney Int 53:1585-1593, 1998
34. 34. MATSUSAKA T, NISHIMURA H, UTSUNOMIYA H, KAKUCHI J, NIJMURA F, INAGAMI T, FOGO A, ICHIKAWA I: Chimeric mice carrying "regional" targeted deletion of the angiotensin type 1A receptor gene: Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest 98:1867-1877, 1996
35. 35. NAVAR LG, IMIG JD, ZOU LX, WANG CT: Intrarenal production of angiotensin II. Semin Nephrol 17:412-422, 1997