Concentration-dependent selection of small phenotypic differences in TEM β-lactamase-mediated antibiotic resistance

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 9, 2000, Pages 2485-2491

  Negri, M C ^a   Lipsitch, M ^a   Blazquez, J ^a   Levin, B R ^a   Baquero, F ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; CEFOTAXIME;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; CHROMOSOME MARKER; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESCHERICHIA COLI; GENETIC VARIABILITY; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CEFOTAXIME; CELL DIVISION; CEPHALOSPORINS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MICE; MODELS, BIOLOGICAL; PHENOTYPE; PORINS; SELECTION (GENETICS);

EID: 0033844973     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.9.2485-2491.2000     Document Type: Article

References (31)

1. Evolution of antibiotic resistance
2. Selective compartments for resistant microorganisms in antibiotic gradients
3. Antibiotic selective environments
4. Single amino acid replacements at positions altered in naturally occurring extended-spectrum TEM β-lactamases
5. Selection of naturally Occurring extended-spectrum TEM β-lactamase variants by fluctuating β-lactam pressure
6. A functional classification scheme for β-lactamases and its correlation with molecular structure
7. Pharmacokinetic/pharmacodynamicparameters: Rationale for antibacterial dosing of mice and men
8. Major proteins of Escherichia coli outer cell envelope membrane as bacteriophage receptors
9. Penicillinase synthesis controlled by infectious R-factors in Enterobacteriaceae
10. Effect of fluoroquinolone concentration on selection of resistant mutants of Mycobactetium bovis BCG and Staphylococcus aureus
11. Interposon mutagenesis of soil and water bacteria: A family of DNA fragments designed for in vitro insertional mutagenesis of Gram negative bacteria
12. Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides
13. Effect of threonineto-methionine substitution at position 265 on structure and function of TEM-1 β-lactamase
14. Role of porin proteins OmpF and OmpC in the permeation of β-lactams
15. Drug concentration heterogeneity facilitates the evolution of drug resistance
16. Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coli K12
17. Constraints on the co-evolution of bacteria and virulent phage: A model, some experiments, and predictions for natural communities
18. Experimental studies of pleiotrophy and epistasis in Escherichia coli. I. Variation in competitive fitness among mutants resistant to virus T4
19. Resource-limited growth, competition, and predation: A model and experimental studies with bacteria and bacteriophage
20. The population genetics of antibiotic resistance
21. Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics
22. Microcins
23. In vitro selective concentrations of β-lactams for penicillin-resistant Streptococcus pneumoniae populations
24. Regulation of outer membrane porin protein synthesis in Escherichia coli K12: OmpF regulates the expression of ompC
25. Beta-lactamases: Protein evolution in real time
26. Factors determining resistance to beta-lactams combined with beta-lactamase inhibitors in Escherichia coli
27. Reducing antibiotic resistance
28. Kanamycin resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pMBL9
29. Long term experimental evolution in Escherichia coli. IV. Targets of selection and specificity of adaptation