메뉴 건너뛰기




Volumn 171, Issue 4, 2003, Pages 1780-1791

Induced dendritic cell differentiation of chronic myeloid leukemia blasts is associated with down-regulation of BCR-ABL

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CD40 ANTIGEN; CD86 ANTIGEN; CELL SURFACE MARKER; CHEMOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL ESTER; PROTEIN KINASE C; TRANSCRIPTION FACTOR; VACCINE;

EID: 0043092262     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.4.1780     Document Type: Article
Times cited : (30)

References (79)
  • 1
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow, P. J., R. J. Jacobson, and T. Papayannopoulou. 1977, Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am. J. Med. 63:125.
    • (1977) Am. J. Med. , vol.63 , pp. 125
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 2
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley, J. D. 1973. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243:290 (Lett.).
    • (1973) Nature 243:290 (Lett.)
    • Rowley, J.D.1
  • 3
    • 0029100438 scopus 로고
    • Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients
    • European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia
    • Kolb, H. J., A. Schattenberg, J. M. Goldman, B. Hertenstein, N. Jacobsen, W. Arcese, P. Ljungman, A. Ferrant, L. Verdonck, D. Niederwieser, et al. 1995. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 86:2041.
    • (1995) Blood , vol.86 , pp. 2041
    • Kolb, H.J.1    Schattenberg, A.2    Goldman, J.M.3    Hertenstein, B.4    Jacobsen, N.5    Arcese, W.6    Ljungman, P.7    Ferrant, A.8    Verdonck, L.9    Niederwieser, D.10
  • 4
    • 0030060436 scopus 로고    scopus 로고
    • Donor leukocyte infusions in the treatment of chronic myeloid leukemia in relapse post bone marrow transplantation
    • Hill, G. R., D. N. Hart, A. F. Moore, and C. M. Morris. 1996. Donor leukocyte infusions in the treatment of chronic myeloid leukemia in relapse post bone marrow transplantation. Pathology 28:51.
    • (1996) Pathology , vol.28 , pp. 51
    • Hill, G.R.1    Hart, D.N.2    Moore, A.F.3    Morris, C.M.4
  • 5
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre, M. E., M. Mohammed, K. Ellwood, N. Hsu, R. Paquette, P. N. Rao, and C. L. Sawyers. 2001. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293:876.
    • (2001) Science , vol.293 , pp. 876
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6    Sawyers, C.L.7
  • 6
    • 0031056587 scopus 로고    scopus 로고
    • Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia
    • Choudhury, A., J. L. Gajewski, J. C. Liang, U. Popat, D. F. Claxton, K. O. Kliche, M. Andreeff, and R. E. Champlin. 1997. Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 89:1133.
    • (1997) Blood , vol.89 , pp. 1133
    • Choudhury, A.1    Gajewski, J.L.2    Liang, J.C.3    Popat, U.4    Claxton, D.F.5    Kliche, K.O.6    Andreeff, M.7    Champlin, R.E.8
  • 11
    • 0030729988 scopus 로고    scopus 로고
    • Dendritic cells generated from blood precursors of chronic myelogenous leukemia patients carry the Philadelphia translocation and can induce a CML-specific primary cytotoxic T-cell response
    • Eibl, B., S. Ebner, C. Duba, G. Bock, N. Romani, M. Erdel, A. Gachter, D. Niederwieser, and G. Schuler. 1997. Dendritic cells generated from blood precursors of chronic myelogenous leukemia patients carry the Philadelphia translocation and can induce a CML-specific primary cytotoxic T-cell response. Genes Chromosomes Cancer 20:215.
    • (1997) Genes Chromosomes Cancer , vol.20 , pp. 215
    • Eibl, B.1    Ebner, S.2    Duba, C.3    Bock, G.4    Romani, N.5    Erdel, M.6    Gachter, A.7    Niederwieser, D.8    Schuler, G.9
  • 12
    • 0027970801 scopus 로고
    • Identification of a malignant counterpart of the monocyte-dendritic cell progenitor in an acute myeloid leukemia
    • Santiago-Schwarz, F., D. L. Coppock, A. A. Hindenburg, and J. Kern. 1994. Identification of a malignant counterpart of the monocyte-dendritic cell progenitor in an acute myeloid leukemia. Blood 84:3054.
    • (1994) Blood , vol.84 , pp. 3054
    • Santiago-Schwarz, F.1    Coppock, D.L.2    Hindenburg, A.A.3    Kern, J.4
  • 16
    • 0035353157 scopus 로고    scopus 로고
    • Stimulation of autologous proliferative and cytotoxic T-cell responses by "leukemic dendritic cells" derived from blast cells in acute myeloid leukemia
    • Harrison, B. D., J. A. Adams, M. Briggs, M. L. Brereton, and J. A. Yin. 2001. Stimulation of autologous proliferative and cytotoxic T-cell responses by "leukemic dendritic cells" derived from blast cells in acute myeloid leukemia. Blood 97:2764.
    • (2001) Blood , vol.97 , pp. 2764
    • Harrison, B.D.1    Adams, J.A.2    Briggs, M.3    Brereton, M.L.4    Yin, J.A.5
  • 17
    • 0033405438 scopus 로고    scopus 로고
    • Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
    • Thurner, B., I. Haendle, C. Roder, D. Dieckmann, P. Keikavoussi, H. Jonuleit, A. Bender, C. Maczek, D. Schreiner, P. von den Driesch, et al. 1999. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J. Exp. Med. 190:1669.
    • (1999) J. Exp. Med. , vol.190 , pp. 1669
    • Thurner, B.1    Haendle, I.2    Roder, C.3    Dieckmann, D.4    Keikavoussi, P.5    Jonuleit, H.6    Bender, A.7    Maczek, C.8    Schreiner, D.9    Von den Driesch, P.10
  • 19
    • 0026446156 scopus 로고
    • GMC-SF and TNF-α cooperate in the generation of dendritic Langerhans cells
    • Caux, C., C. Dezutter-Dambuyant, D. Schmitt, and J. Banchereau. 1992. GMC-SF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 360:258.
    • (1992) Nature , vol.360 , pp. 258
    • Caux, C.1    Dezutter-Dambuyant, C.2    Schmitt, D.3    Banchereau, J.4
  • 20
    • 0029162640 scopus 로고
    • + bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor α
    • + bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor α. J. Exp. Med. 182:1111.
    • (1995) J. Exp. Med. , vol.182 , pp. 1111
    • Young, J.W.1    Szabolcs, P.2    Moore, M.A.3
  • 25
    • 0033566626 scopus 로고    scopus 로고
    • Calcium ionophore-treated myeloid cells acquire many dendritic cell characteristics independent of prior differentiation state, transformation status, or sensitivity to biologic agents
    • Koski, G. K., G. N. Schwartz, D. E. Weng, R. E. Gress, F. H. Engels, M. Tsokos, B. J. Czerniecki, and P. A. Cohen. 1999. Calcium ionophore-treated myeloid cells acquire many dendritic cell characteristics independent of prior differentiation state, transformation status, or sensitivity to biologic agents. Blood 94:1359.
    • (1999) Blood , vol.94 , pp. 1359
    • Koski, G.K.1    Schwartz, G.N.2    Weng, D.E.3    Gress, R.E.4    Engels, F.H.5    Tsokos, M.6    Czerniecki, B.J.7    Cohen, P.A.8
  • 27
    • 0034883007 scopus 로고    scopus 로고
    • Calcium ionophore: A single reagent for the differentiation of primary human acute myelogenous leukaemia cells towards dendritic cells
    • Waclavicek, M., A. Berer, L. Oehler, J. Stockl, E. Schloegl, O. Majdic, and W. Knapp. 2001. Calcium ionophore: a single reagent for the differentiation of primary human acute myelogenous leukaemia cells towards dendritic cells. Br. J. Haematol. 114:466.
    • (2001) Br. J. Haematol. , vol.114 , pp. 466
    • Waclavicek, M.1    Berer, A.2    Oehler, L.3    Stockl, J.4    Schloegl, E.5    Majdic, O.6    Knapp, W.7
  • 31
    • 0033168650 scopus 로고    scopus 로고
    • Calcium mobilization in human myeloid cells results in acquisition of individual dendritic cell-like characteristics through discrete signaling pathways
    • Koski, G. K., G. N. Schwartz, D. E. Weng, B. J. Czerniecki, C. Carter, R. E. Gress, and P. A. Cohen. 1999. Calcium mobilization in human myeloid cells results in acquisition of individual dendritic cell-like characteristics through discrete signaling pathways. J. Immunol. 163:82.
    • (1999) J. Immunol. , vol.163 , pp. 82
    • Koski, G.K.1    Schwartz, G.N.2    Weng, D.E.3    Czerniecki, B.J.4    Carter, C.5    Gress, R.E.6    Cohen, P.A.7
  • 32
    • 0032810007 scopus 로고    scopus 로고
    • Human acute myeloblastic leukemia cells differentiate in vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous leukemias
    • Charbonnier, A., B. Gaugler, D. Sainty, M. Lafage-Pochitaloff, and D. Olive. 1999. Human acute myeloblastic leukemia cells differentiate in vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous leukemias. Eur. J. Immunol. 29:2567.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 2567
    • Charbonnier, A.1    Gaugler, B.2    Sainty, D.3    Lafage-Pochitaloff, M.4    Olive, D.5
  • 33
  • 34
    • 0033058936 scopus 로고    scopus 로고
    • Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their T-cells stimulatory activity by IFN-α
    • Wang, C., H. M. Al-Omar, L. Radvanyi, A. Banerjee, D. Bouman, J. Squire, and H. A. Messner. 1999. Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their T-cells stimulatory activity by IFN-α. Exp. Hematol. 27:1176.
    • (1999) Exp. Hematol. , vol.27 , pp. 1176
    • Wang, C.1    Al-Omar, H.M.2    Radvanyi, L.3    Banerjee, A.4    Bouman, D.5    Squire, J.6    Messner, H.A.7
  • 37
  • 38
    • 0026608119 scopus 로고
    • Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro
    • Gishizky, M. L., and O. N. Witte. 1992. Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro. Science 256:836.
    • (1992) Science , vol.256 , pp. 836
    • Gishizky, M.L.1    Witte, O.N.2
  • 39
    • 0037007431 scopus 로고    scopus 로고
    • BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor
    • Pierce, A., E. Spooncer, S. Ainsworth, and A. D. Whetton. 2002. BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor. Oncogene 21:3068.
    • (2002) Oncogene , vol.21 , pp. 3068
    • Pierce, A.1    Spooncer, E.2    Ainsworth, S.3    Whetton, A.D.4
  • 40
    • 0025036881 scopus 로고
    • Lineage non-specific down regulation of P210bcr/abl in the CML cell line, KU-812-F, during differentiation
    • Takahira, H., J. Nishimura, K. Shibata, J. Hirata, T. Umemura, and H. Nawata. 1990. Lineage non-specific down regulation of P210bcr/abl in the CML cell line, KU-812-F, during differentiation. Leuk. Res. 14:801.
    • (1990) Leuk. Res. , vol.14 , pp. 801
    • Takahira, H.1    Nishimura, J.2    Shibata, K.3    Hirata, J.4    Umemura, T.5    Nawata, H.6
  • 41
    • 0023772690 scopus 로고
    • Effect of differentiation-inducing agents on oncogene expression in a chronic myelogenous leukemia cell line
    • Eisbruch, A., M. Blick, M. J. Evinger-Hodges, M. Beran, B. Andersson, J. U. Gutterman, and R. Kurzrock. 1988. Effect of differentiation-inducing agents on oncogene expression in a chronic myelogenous leukemia cell line. Cancer 62:1171.
    • (1988) Cancer , vol.62 , pp. 1171
    • Eisbruch, A.1    Blick, M.2    Evinger-Hodges, M.J.3    Beran, M.4    Andersson, B.5    Gutterman, J.U.6    Kurzrock, R.7
  • 42
    • 0027332537 scopus 로고
    • Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate
    • Anafi, M., A. Gazit, A. Zehavi, Y. Ben-Neriah, and A. Levitzki. 1993. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood 82:3524.
    • (1993) Blood , vol.82 , pp. 3524
    • Anafi, M.1    Gazit, A.2    Zehavi, A.3    Ben-Neriah, Y.4    Levitzki, A.5
  • 47
    • 0016640079 scopus 로고
    • Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome
    • Lozzio, C. B., and B. B. Lozzio. 1975. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 45:321.
    • (1975) Blood , vol.45 , pp. 321
    • Lozzio, C.B.1    Lozzio, B.B.2
  • 50
    • 0022900640 scopus 로고
    • Ditferentiation of K562 leukemia cells along erythroid, macrophage, and megakaryocyte lineages
    • Sutherland, J. A., A. R. Turner, P. Mannoni, L. E. McGann, and J. M. Turc. 1986. Ditferentiation of K562 leukemia cells along erythroid, macrophage, and megakaryocyte lineages. J. Biol. Response Mod. 5:250.
    • (1986) J. Biol. Response Mod. , vol.5 , pp. 250
    • Sutherland, J.A.1    Turner, A.R.2    Mannoni, P.3    McGann, L.E.4    Turc, J.M.5
  • 51
    • 0025363266 scopus 로고
    • Induced differentiation of K562 leukemia cells: A model for studies of gene expression in early megakaryoblast
    • Alitalo, R. 1990. Induced differentiation of K562 leukemia cells: a model for studies of gene expression in early megakaryoblast. J. Leuk. Res. 14:501.
    • (1990) J. Leuk. Res. , vol.14 , pp. 501
    • Alitalo, R.1
  • 52
    • 0031000626 scopus 로고    scopus 로고
    • Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase
    • Whalen, A. M., S. C. Galasinski, P. S. Shapiro, T. S. Nahreini, and N. G. Ahn. 1997. Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol. Cell. Biol. 17:1947.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1947
    • Whalen, A.M.1    Galasinski, S.C.2    Shapiro, P.S.3    Nahreini, T.S.4    Ahn, N.G.5
  • 54
    • 0031825731 scopus 로고    scopus 로고
    • A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: Modulation of megakaryocytic differentiation of K562 cells
    • Herrera, R., S. Hubbell, S. Decker, and L. Petruzzelli, 1998. A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells. Exp. Cell. Res. 238:407.
    • (1998) Exp. Cell. Res. , vol.238 , pp. 407
    • Herrera, R.1    Hubbell, S.2    Decker, S.3    Petruzzelli, L.4
  • 55
    • 0036316544 scopus 로고    scopus 로고
    • Extension, retraction and contraction in the formation of a dendritic cell dendrite: Distinct roles for Rho GTPases
    • Swetman, C. A., Y. Leverrier, R. Garg, C. H. Gan, A. J. Ridley, D. R. Katz, and B, M. Chain. 2002. Extension. retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases. Eur. J. Immunol. 32:2074.
    • (2002) Eur. J. Immunol. , vol.732 , pp. 2074
    • Swetman, C.A.1    Leverrier, Y.2    Garg, R.3    Gan, C.H.4    Ridley, A.J.5    Katz, D.R.6    Chain, B.M.7
  • 57
    • 0030938632 scopus 로고    scopus 로고
    • Dendritic cells in the T-cell areas of lymphoid organs
    • Steinman, R. M., M. Pack, and K. Inaba. 1997. Dendritic cells in the T-cell areas of lymphoid organs. Immunol. Rev. 156:25.
    • (1997) Immunol. Rev. , vol.156 , pp. 25
    • Steinman, R.M.1    Pack, M.2    Inaba, K.3
  • 58
    • 0028931430 scopus 로고
    • Membrane-associated and soluble granulocyte/ macrophage-colony-stimulating factor receptor a subunits are independently regulated in HL-60 cells
    • Heaney, M. L., J. C. Vera, M. A. Raines, and D. W. Golde. 1995. Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor a subunits are independently regulated in HL-60 cells. Proc. Natl. Acad. Sci. USA 92:2365.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2365
    • Heaney, M.L.1    Vera, J.C.2    Raines, M.A.3    Golde, D.W.4
  • 60
    • 0027240631 scopus 로고
    • Expression of relB transcripts during lymphoid organ development: Specific expression in dendritic antigen-presenting cells
    • Carrasco, D., R. P. Ryseck, and R. Bravo. 1993. Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells. Development 118:1221.
    • (1993) Development , vol.118 , pp. 1221
    • Carrasco, D.1    Ryseck, R.P.2    Bravo, R.3
  • 62
    • 0032826292 scopus 로고    scopus 로고
    • Expression of the RelB transcription factor correlates with the activation of human dendritic cells
    • Clark, G. J., S. Gunningham, A. Troy, S. Vuckovic, and D. N. Hart. 1999. Expression of the RelB transcription factor correlates with the activation of human dendritic cells. Immunology 98:189.
    • (1999) Immunology , vol.98 , pp. 189
    • Clark, G.J.1    Gunningham, S.2    Troy, A.3    Vuckovic, S.4    Hart, D.N.5
  • 63
    • 0037240852 scopus 로고    scopus 로고
    • Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10
    • Martin, E., B. O'Sullivan, P. Low, and R. Thomas. 2003. Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity 18:155.
    • (2003) Immunity , vol.18 , pp. 155
    • Martin, E.1    O'Sullivan, B.2    Low, P.3    Thomas, R.4
  • 65
    • 0035918164 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase/90-KDA ribosomal S6 kinase/nuclear factor-κB pathway mediates phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells
    • Kim, K. W., S. H. Kim, E. Y. Lee, N. D. Kim, H. S. Kang, H. D. Kim, B. S. Chung, and C. D. Kang. 2001. Extracellular signal-regulated kinase/90-KDA ribosomal S6 kinase/nuclear factor-κB pathway mediates phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells. J. Biol. Chem. 276:13186.
    • (2001) J. Biol. Chem. , vol.276 , pp. 13186
    • Kim, K.W.1    Kim, S.H.2    Lee, E.Y.3    Kim, N.D.4    Kang, H.S.5    Kim, H.D.6    Chung, B.S.7    Kang, C.D.8
  • 67
    • 0036199656 scopus 로고    scopus 로고
    • Dendritic cell development and survival require distinct NF-κB subunits
    • Ouaaz, F., J. Arron, Y. Zheng, Y. Choi, and A. A. Beg. 2002. Dendritic cell development and survival require distinct NF-κB subunits. Immunity 16:257.
    • (2002) Immunity , vol.16 , pp. 257
    • Ouaaz, F.1    Arron, J.2    Zheng, Y.3    Choi, Y.4    Beg, A.A.5
  • 68
    • 0036139121 scopus 로고    scopus 로고
    • Optimal cytokine stimulation for the enhanced generation of leukemic dendritic cells in short-term culture
    • Panoskaltsis, N., T. J. Belanger, J. L. Liesveld, and C. N. Abboud. 2002. Optimal cytokine stimulation for the enhanced generation of leukemic dendritic cells in short-term culture. Leuk. Res. 26:191.
    • (2002) Leuk. Res. , vol.26 , pp. 191
    • Panoskaltsis, N.1    Belanger, T.J.2    Liesveld, J.L.3    Abboud, C.N.4
  • 70
    • 0026648425 scopus 로고
    • Single K562 human leukemia cells express and are inducible for both erythroid and megakaryocytic antigens
    • Rowley, P. T., B. A. Farley, S. LaBella, R. Giuliano, and J. F. Leary. 1992. Single K562 human leukemia cells express and are inducible for both erythroid and megakaryocytic antigens. Int. J. Cell Cloning 10:232.
    • (1992) Int. J. Cell Cloning , vol.10 , pp. 232
    • Rowley, P.T.1    Farley, B.A.2    LaBella, S.3    Giuliano, R.4    Leary, J.F.5
  • 73
    • 0023200158 scopus 로고
    • The bcr-c-abl tyrosine kinase activity is extinguished by TPA in K562 leukemia cells
    • Alitalo, R. 1987. The bcr-c-abl tyrosine kinase activity is extinguished by TPA in K562 leukemia cells. FEBS Lett. 222:293.
    • (1987) FEBS Lett. , vol.222 , pp. 293
    • Alitalo, R.1
  • 74
    • 0027630895 scopus 로고
    • Inhibition of phosphorylation of p160 BCR within p210 BCR-ABL complexes during early stages of phorbol ester-induced differentiation of K562 cells
    • Campbell, M. L. D. Lu, J. Q. Guo, and R. B. Arlinghaus. 1993. Inhibition of phosphorylation of p160 BCR within p210 BCR-ABL complexes during early stages of phorbol ester-induced differentiation of K562 cells. Cell Growth Differ. 4:581.
    • (1993) Cell Growth Differ. , vol.4 , pp. 581
    • Campbell1    Lu, M.L.D.2    Guo, J.Q.3    Arlinghaus, R.B.4
  • 75
    • 0037049766 scopus 로고    scopus 로고
    • Novel targeted therapies for Bcr-Abl positive acute leukemias: Beyond STI571
    • Nimmanapalli, R., and K. Bhalla. 2002. Novel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571. Oncogene 21:8584.
    • (2002) Oncogene , vol.21 , pp. 8584
    • Nimmanapalli, R.1    Bhalla, K.2
  • 76
    • 0030866934 scopus 로고    scopus 로고
    • Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells
    • Racke, F. K., K. Lewandowska, S. Goueli, and A. N. Goldfarb. 1997. Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells. J. Biol. Chem. 272:23366.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23366
    • Racke, F.K.1    Lewandowska, K.2    Goueli, S.3    Goldfarb, A.N.4
  • 77
    • 0034876108 scopus 로고    scopus 로고
    • The role of Bcr-Abl in chronic myeloid leukemia and stem cell biology
    • Witte, O. 2001. The role of Bcr-Abl in chronic myeloid leukemia and stem cell biology. Semin. Hematol. 38:3.
    • (2001) Semin. Hematol. , vol.38 , pp. 3
    • Witte, O.1
  • 78
    • 0035122485 scopus 로고    scopus 로고
    • Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase
    • Vigneri, P., and J. Y. Wang. 2001. Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat. Med. 7:228.
    • (2001) Nat. Med. , vol.7 , pp. 228
    • Vigneri, P.1    Wang, J.Y.2
  • 79
    • 0027074074 scopus 로고
    • BCR/ABL enhances growth of multipotent progenitor cells but does not block their differentiation potential in vitro
    • Gishizky, M. L., and O. N. Witte. 1992. BCR/ABL enhances growth of multipotent progenitor cells but does not block their differentiation potential in vitro. Curr. Top. Microbiol. Immunol. 182:65.
    • (1992) Curr. Top. Microbiol. Immunol. , vol.182 , pp. 65
    • Gishizky, M.L.1    Witte, O.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.