Calcium Ionophore-Treated Peripheral Blood Monocytes and Dendritic Cells Rapidly Display Characteristics of Activated Dendritic Cells

Journal of Immunology

Volumn 159, Issue 8, 1997, Pages 3823-3837

  Czerniecki, Brian J ^a,d   Carter, Charles ^b   Rivoltini, Licia ^c,e   Koski, Gary K ^c   Kim, Hyun I ^c   Weng, David E ^c   Roros, James G ^a   Hijazi, Yasmine M ^c   Xu, Shuwen ^a   Rosenberg, Steven A ^c   Cohen, Peter A ^c  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d AMERICAN CANCER SOCIETY   (United States)

^e NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CALCIMYCIN; ENDOTOXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; IONOMYCIN; RECOMBINANT PROTEIN;

ARTICLE; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CULTURE; CENTRIFUGATION; CLASSIFICATION; CULTURE MEDIUM; CYTOLOGY; DENDRITIC CELL; DRUG COMBINATION; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOPHENOTYPING; LEUKAPHERESIS; MACROPHAGE ACTIVATION; MONOCYTE; MONONUCLEAR CELL;

BONE MARROW CELLS; CALCIMYCIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CENTRIFUGATION; CULTURE MEDIA; DENDRITIC CELLS; DRUG COMBINATIONS; ENDOTOXINS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-4; IONOMYCIN; ISOANTIGENS; LEUKAPHERESIS; LEUKOCYTES, MONONUCLEAR; MACROPHAGE ACTIVATION; MONOCYTES; RECOMBINANT PROTEINS;

EID: 0031572507     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Croft, M., L. M. Bradley, and S. L. Swain. 1994. Naive versus memory CD4 T cell response to antigen: memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J. Immunol. 152:2675.
2. Crowley, M., K. Inaba, and R. M. Steinman. 1990. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172:383.
3. Nair, S., F. Zhou, R. Reddy, L. Huang, and B. T. Rouse. 1992. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J. Exp. Med. 175:609.
4. Huang, A. Y., P. Golumbek, M. Ahmadzadeh, E. Jaffee, D. Pardoll, and H. Levitsky. 1994. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264:961.
5. Grabbe, S., S. Bruvers, R. L. Gallo, T. L. Knisely, R. Nazareno, and R. D. Granstein. 1991. Tumor antigen presentation by murine epidermal cells. J. Immunol. 146:3656.
6. Shimizu, J., J. P. Zou, K. Ikegame, T. Katagiri, H. Fujiwara, and T. Hamaoka. 1991. Evidence for the functional binding in vivo of tumor rejection antigens to antigen-presenting cells in tumor-bearing hosts. J. Immunol. 146:1708.
7. Freudenthal, P. S., and R. M. Steinman. 1990. The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc. Natl. Acad. Sci. USA 87:7698.
8. Mayordomo, J. I., T. Tjandrawan, A. B. DeLeo, M. R. Clarke, M. T. Lotze, and W. J. Storkus. 1996. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med. 183:87.
9. Mayordomo, J. I., T. Zorina, W. J. Storkus, L. Zitvogel, C. Celluzzi, L. D. Falo, C. J. Melief, S. T. Ildstad, W. M. Kast, and A. B. DeLeo. 1995. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat. Med. 1:1297.
10. Hsu, F. J., C. Benike, F. Fagnoni, T. M. Liles, D. Czerwinski, B. Taidi, E. G. Engleman, and R. Levy. 1996. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med. 2:52.
11. Caux, C., C. Dezutter-Dambuyant, D. Schmitt, and J. Banchereau. 1992. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258.
12. Gieseler, R. K., R. A. Rober, R. Kuhn, K. Weber, M. Osborn, and J. H. Peters. 1991. Dendritic accessory cells derived from rat bone marrow precursors under chemically defined conditions in vitro belong to the myeloid lineage. Eur. J. Cell Biol. 54:171.
13. Romani, N., S. Gruner, D. Brang, E. Kampgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P. O. Fritsch, R. M. Steinman, and G. Schuler. 1994. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83.
14. Peters, J. H., R. Gieseler, B. Thiele, and F. Steinbach. 1996. Dendritic cells: from ontogenetic orphans to myelomonocytic descendants. Immunol. Today 17:273.
15. Thomas, R., L. S. Davis, and P. E. Lipsky. 1993. Comparative accessory cell function of human peripheral blood dendritic cells and monocytes. J. Immunol. 151:6840.
16. Thomas, R., L. S. Davis, and P. E. Lipsky. 1993. Isolation and characterization of human peripheral blood dendritic cells. J. Immunol. 150:821.
17. Thomas, R., and P. E. Lipsky. 1994. Human peripheral blood dendritic cell subsets: isolation and characterization of precursor and mature antigen-presenting cells. J. Immunol. 153:4016.
18. Nijman, H. W., M. J. Kleijmeer, M. A. Ossevoort, V. M. Oorschot, M. P. Vierboom, M. van de Keur, P. Kenemans, W. M. Kast, H. J. Geuze, and C. J. Melief. 1995. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells. J. Exp. Med. 182:163.
19. Knight, S. C., J. Farrant, A. Bryant, A. J. Edwards, S. Burman, A. Lever, J. Clarke, and A. D. Webster. 1986. Non-adherent, low-density cells from human peripheral blood contain dendritic cells and monocytes, both with veiled morphology. Immunology 57:595.
20. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J. Exp. Med. 184:695.
21. Szabolcs, P., D. Avigan, S. Gezelter, D. H. Ciocon, M. A. Moore, R. M. Steinman, and J. W. Young. 1996. Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate. Blood 87:4520.
22. + peripheral blood monocytes. J. Immunol. 157:3850.
23. + dendritic cells. Proc. Natl. Acad. Sci. USA 93:2588.
24. + leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4. J. Leukocyte Biol. 59:208.
25. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179:1109.
26. Ruppert, J., C. Schutt, D. Ostermeier, and J. H. Peters. 1993. Down-regulation and release of CD14 on human monocytes by IL-4 depends on the presence of serum or GM-CSF. Adv. Exp. Med. Biol. 329:281.
27. Kabel, P. J., M. de Haan-Meulman, H. A. Voorbij, M. Kleingeld, E. F. Knol, and H. A. Drexhage. 1989. Accessory cells with a morphology and marker pattern of dendritic cells can be obtained from elutriator-purified blood monocyte fractions: an enhancing effect of metrizamide in this differentiation. Immunobiology 179:395.
28. Peters, J. H., J. Ruppert, R. K. Gieseler, H. M. Najar, and H. Xu. 1991. Differentiation of human monocytes into CD14 negative accessory cells: do dendritic cells derive from the monocytic lineage? Pathobiology 59:122.
29. + T cells in culture with maintained antigen specificity. J. Immunother. 14:242.
30. Abrahamsen, T. G., C. S. Carter, E. J. Read, M. Rubin, H. G. Goetzman, E. F. Lizzio, Y. L. Lee, M. Hanson, P. A. Pizzo, and T. Hoffman. 1991. Stimulatory effect of counterflow centrifugal elutriation in large-scale separation of peripheral blood monocytes can be reversed by storing the cells at 37 degrees C. J. Clin. Apheresis 6:48.
31. Rivoltini, L., Y. Kawakami, K. Sakaguchi, S. Southwood, S. Alessandro, P. F. Robbins, F. M. Marincola, M. L. Salgaller, J. R. Yannelli, E. Appella, and S. A. Rosenberg. 1995. Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1. J. Immunol. 154:2257.
32. Tsomides, T. J., A. Aldovini, R. P. Johnson, B. D. Walker, R. A. Young, and H. N. Eisen. 1994. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J. Exp. Med. 180:1283.
33. Rivoltini, L., D. J. Loftus, K. Barracchini, F. Arienti, A. Mazzocchi, W. E. Biddison, M. L. Salgaller, E. Appella, G. Parmiani, and F. M. Marincola. 1996. Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein-100 by HLA-A2 subtypes: implications for peptide-based immunotherapy. J. Immunol. 156:3882.
34. Miltenyi, S., W. Muller, W. Weichel, and A. Radbruch. 1990. High gradient magnetic cell separation with MACS. Cytometry 11:231.
35. Cohen, P. A., D. J. Fowler, H. Kim, R. L. White, B. J. Czerniecki, C. Carter, R. E. Gress, and S. A. Rosenberg. 1994. Propagation of murine and human T cells with defined antigen specificity and function. In Ciba Foundation Symposium No. 187: Vaccines Against Virally Induced Cancers. I. Frazer, D. Chadwick, and J. Marsh, eds. Wiley & Sons Ltd., Chichester, p. 179.
36. + blood dendritic cells. Blood 86:3295.
37. Zhou, L. J., and T. F. Tedder. 1995. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154: 3821.
38. Scheibenbogen, C., and U. Keilholz. 1995. Lipopolysaccharide effectively up-regulates B7-1 (CD80) expression and costimulatory function of human monocytes. Scand. J. Immunol. 42:701.
39. Lenschow, D. J., G. H. Su, L. A. Zuckerman, N. Nabavi, C. L. Jellis, G. S. Gray, J. Miller, and J. A. Bluestone. 1993. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA 90:11054.
40. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182:389.
41. Fanger, N. A., K. Wardwell, L. Shen, T. F. Tedder, and P. M. Guyre. 1996. Type I (CD64) and type II (CD32) Fcγ receptor-mediated phagocytosis by human blood dendritic cells. J. Immunol. 157:541.
42. + T cell lines from naive precursors. Eur. J. Immunol. 25:1206.
43. Kawakami, Y., S. Eliyahu, C. H. Delgado, P. F. Robbins, K. Sakaguchi, E. Appella, J. R. Yannelli, G. J. Adema, T. Miki, and S. A. Rosenberg. 1994. Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Natl. Acad. Sci. USA 91:6458.
44. Kawakami, Y., S. Eliyahu, K. Sakaguchi, P. F. Robbins, L. Rivoltini, J. R. Yannelli, E. Appella, and S. A. Rosenberg. 1994. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J. Exp. Med. 180:347.
45. Kawakami, Y., S. Eliyahu, C. H. Delgado, P. F. Robbins, L. Rivoltini, S. L. Topalian, T. Miki, and S. A. Rosenberg. 1994. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl. Acad. Sci. USA 91:3515.
46. + CTLs from naive precursors. J. Immunol. 153:996.
47. Fujihara, M., T. A. Takahashi, M. Azuma, C. Ogiso, T. L. Maekawa, H. Yagita, K. Okumura, and S. Sekiguchi. 1996. Decreased inducible expression of CD80 and CD86 in human monocytes after ultraviolet-B irradiation: its involvement in inactivation of allogenecity. Blood 87:2386.
48. McLellan, A. D., G. C. Starling, L. A. Williams, B. D. Hock, and D. N. Hart. 1995. Activation of human peripheral blood dendritic cells induces the CD86 co-stimulatory molecule. Eur. J. Immunol. 25:2064.
49. + precursors. J. Immunol. 158:2134.
50. + T cells. J. Immunol. 155:4111.
51. Azuma, M., D. Ito, H. Yagita, K. Okumura, J. H. Phillips, L. L. Lanier, and C. Somoza. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76.
52. Engel, P., J. G. Gribben, G. J. Freeman, L. J. Zhou, Y. Nozawa, M. Abe, L. M. Nadler, H. Wakasa, and T. F. Tedder. 1994. The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood 84:1402.
53. + T-cell immune responses induced by dendritic cells. Immunology 85:467.
54. Thomas, R., and C. Quinn. 1996. Functional differentiation of dendritic cells in rheumatoid arthritis: role of CD86 in the synovium. J. Immunol. 156:3074.
55. Cruz, P. D., and P. R. Bergstresser. 1990. Antigen processing and presentation by epidermal Langerhans cells, induction of immunity or unresponsiveness. Dermatoi. Clin. 8:633.
56. Girolomoni, G., J. C. Simon, P. R. Bergstresser, and P. D. Cruz. 1990. Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short term culture. J. Immunol. 145:2820.
57. Chengzheng, L., and Z. Youhui. 1991. Phorbol myristate acetate and calcium ionophore A23187 modulate the accessory cell function of mouse dendritic cells. Chin. Med. Sci. J. 6:18.
58. O'Doherty, U., M. Peng, S. Gezelter, W. J. Swiggard, M. Betjes, N. Bhardwaj, and R. M. Steinman. 1994. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 82:487.
59. Gabrilovich, D., I. F. Ciernik, S. Nadif, J. Corak, and D. P. Carbone. 1996. Dendritic cells grown from bone marrow precursors but not mature DC from tumor bearing mice can be effective antigen carriers in the therapy of established tumors. Cancer Res. 37:475.