Cytokine-driven differentiation of blasts from patients with acute myelogenous and lymphoblastic leukemia into dendritic cells

Stem Cells

Volumn 18, Issue 2, 2000, Pages 139-147

  Kohler T ^a   Plettig, R ^a   Wetzstein, W ^a   Schmitz, M ^a   Ritter, M ^a   Mohr, B ^a   Schaekel, U ^a   Ehninger, G ^a   Bornhauser M ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Acute leukemia; Chromosomal aberrations; Dendritic cells; Immunotherapy

Indexed keywords

CD1 ANTIGEN; CD14 ANTIGEN; CYTOKINE; FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BLAST CELL; CELL CULTURE; CELL DIFFERENTIATION; CHROMOSOME 16; CHROMOSOME ABERRATION; CHROMOSOME INVERSION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; MONOSOMY 7;

EID: 0343091453     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.18-2-139     Document Type: Article

References (27)

1. Grimwade D, Walker H, Oliver F et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. Blood 1998;92:2322-2333.
2. Anderlini P, Luna M, Kantarjian HM et al. Causes of initial remission induction failure in patients with acute myeloid leukemia and myelodysplastic syndromes. Leukemia 1996;10:600-608.
3. + cells. Bone Marrow Transplant 1996;18:997-1008.
4. Eibl B, Ebner S, Duba C et al. Dendritic cells generated from blood precursors of chronic myelogenous leukemia patients carry the Philadelphia translocation and can induce a CML-specific primary cytotoxic T-cell response. Genes Chromosomes Cancer 1997;20:215-223.
5. Fearnley DB, McLellan AD, Mannering SI et al. Isolation of human blood dendritic cells using the CMRF-44 monoclonal antibody: implications for studies on antigen-presenting cell function and immunotherapy. Blood 1997;89:3708-3716.
6. Choudhury A, Toubert A, Sutaria S et al. Human leukemia-derived dendritic cells: ex-vivo development of specific antileukemic cytotoxicity. Crit Rev Immunol 1998;18:121-131.
7. Choudhury A, Gajewski JL, Liang JC et al. Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 1997;89:1133-1142.
8. Robinson SP, English N. Jaju R et al. The in-vitro generation of dendritic cells from blast cells in acute leukaemia. Br J Haematol 1998;103:763-771.
9. Choudhury A, Liang JC, Thomas EK et al. Dendritic cells derived in vitro from acute myelogenous leukemia cells stimulate autologous, antileukemic T cell responses. Blood 1999;93:780-786.
10. Stockschlader M, Hegewisch BS, Kruger W et al. Bone marrow transplantation for Philadelphia-chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant 1995;16:663-667.
11. Kolb HJ, Schattenberg A, Goldman JM et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 1995;86:2041-2050.
12. Ritter M, Thiede C, Schäkel U et al. Underestimation of inversion (16) in acute myeloid leukaemia using standard cytogenetics as compared with polymerase chain reaction: results of a prospective investigation. Br J Haematol 1997;98:969-972.
13. Colovai AI, Suciu Foca N, Baiulescu GE et al. HLA class I self peptides isolated from a T-cell leukemia reveal the allele-specific motif of HLA-B38. Tissue Antigens 1994;44:65-72.
14. Dolstra H, Fredrix H, Maas F et al. A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia. J Exp Med 1999;189:301-308.
15. + acute myeloid and lymphoid leukemic blasts can be induced to differentiate into dendritic cells. Blood 1999;94:2048-2055.
16. Charbonnier A, Gaugler B, Sainty D et al. Human acute myeloblastic leukemia cells differentiate in vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous leukemias. Eur J Immunol 1999;29:2567-2578.
17. + T cells in vitro. Blood 1998;91:4652-4661.
18. + progenitor cells. Exp Hematol 1998;26:489-.500.
19. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-737.
20. + peripheral blood progenitor cell and monocyte derived dendritic cells: a comparative analysis. Br J Haematol 1997;99:490-499.
21. Reis e Sousa C, Stahl PD, Austyn JM. Phagocytosis of antigens by Langerhans cells in vitro. J Exp Med 1993;178:509-519.
22. Galy A, Morel F, Hill B et al. Hematopoietic progenitor cells of lymphocytes and dendritic cells. J Immunother 1998;21:132-141.
23. Ibisch C, Gallot G, Vivien R et al. Recognition of leukemic blasts by HLA-DPB1-specific cytotoxic T cell clones: a perspective for adjuvant immunotherapy post-bone marrow transplantation. Bone Marrow Transplant 1999;23:1153-1159.
24. Ostankovitch M, Buzyn A, Bonhomme D et al. Antileukemic HLA-restricted T-cell clones generated with naturally processed peptides eluted from acute myeloblastic leukemia blasts. Blood 1998;92:19-24.
25. Mutis T, Schrama E, Melief CJM et al. CD80-transfected acute myeloid leukemia cells induce primary allogeneic T-cell responses dircetd at patient specific minor histocompatibility antigens and leukemia-associated antigens. Blood 1998;92:1677-1684.
26. + minor histocompatibilty antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells. Proc Natl Acad Sci USA 1999;96:8639-8644.
27. Mutis T, Verdijk B, Schrama E et al. Feasibility of immunotherapy of relapsed leukemia with ex vivo-generated cytotoxic T lymphocytes specific for hematopoietic system-restricted minor histocompalibility antigens. Blood 1999;93:2236-2341.