Dendritic cells stimulate the expansion of bcr-abl specific CD8+ T cells with cytotoxic activity against leukemic cells from patients with chronic myeloid leukemia

Blood

Volumn 91, Issue 3, 1998, Pages 977-983

  Nieda, Mie ^a   Nicol, Andrew ^b   Kikuchi, Akiko ^b   Kashiwase, Koichi ^b   Taylor, Kerry ^b   Suzuki, Kenji ^b   Tadokoro, Kenji ^b   Juji, Takeo ^b  

^a JAPANESE RED CROSS MEDICAL CENTER   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; PHYTOHEMAGGLUTININ;

ALLOIMMUNITY; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW TRANSPLANTATION; CELL KILLING; CHRONIC MYELOID LEUKEMIA; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNOGENICITY; LEUKEMIA CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL;

EID: 0032005138     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.3.977     Document Type: Article

References (19)

1. 1 translocation. Nature 315:758, 1985
2. Grosveld G, Verwoerd T, Van Agthove T, De Klein A, Ramachandran KL, Stam K, Groffen J: The chronic myelocyte cell line K562 contains a breakpoint in bcr and produces a chimeric bcr-c-abl transcript. Mol Cell Biol 6:607, 1986
3. Kurzrock R, Gutterman JU, Talpaz M: The molecular genetics of the Philadelphia chromosome-positive leukemias. N Engl J Med 39:990, 1988
4. Collins RH Jr, Shpilberg O, Drobyski WR, Porter DL, Giralt S, Champlin R, Goodman SA, Wolff SN, Hu W, Verfaillie C, List A, Dalton W, Ognoskie N, Cherit A, Antin JH, Nemunaitis J: Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. J Clin Oncol 15:433, 1997
5. Kolb JH, Mittermuller J, Clemm C, Ledderooe C, Brehm G, Heim M, Wilmans W: Donor leukocyte infusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 76:2462, 1990
6. Bocchia M, Wentworth PA, Southwood S, Sidney J, McGraw K, Scheinberg DA, Sette A: Specific binding of leukemia oncogene fusion protein peptides to HLA class 1 molecules. Blood 85:2680, 1995
7. ten Bosch GJA, Joosten AM, Kessler JH, Melief CJM, Leeksma OC: Recognition of BCR-ABL positive leukemic blasts by human CD4+T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide. Blood 88:3522, 1996
8. Pawelec G, Max H, Halder T, Bruserud O, Merl A, da Silva P, Kalbacher H: BCR/ABL leukaemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors. Blood 88:2118, 1996
9. Bocchia M, Korontsvit T, Xu Q, Mackinnon S, Yang SY, Sette A, Scheinberg DA: Specific human cellular immunity to bcr-abl oncogene-derived peptides. Blood 87:3587, 1996
10. Choudhury A, Gajewski JL, Liang JC, Popat U, Claxton DF, Kliche K-O, Andreeff M, Champlin RE: Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 89: 1133, 1997
11. 1+) human leukemia lines can also recognize Ph1-cells from the same patient. Blood 83:3390, 1994
12. Hsu FJ, Benike C, Fagnoni F, Liles TM, Czerwinski D, Taidi B, Engleman EG, Levy R: Vaccination of patients with B-cell lymphoma using autologous antigen pulsed dendritic cells. Nat Med 2:52, 1996
13. Maier R, Falk K, Roetzschke O, Maier B, Gnau V, Stevanovic S, Jung G, Rammensee HG, Meyerhaus A: Peptide motifs of HLA-A3, -A24 and -B7 molecules as determined by pool sequencing. Immunogenetics 40:306, 1994
14. Falk K, Roetzschke O, Stevanovic S, Jung G, Rammensee HG: Allele-specific motifs revealed by sequencing of self peptides eluted from MHC molecules. Nature 351:290, 1991
15. Cullis JO, Barret AJ, Goldman JM, Lechler RI: Binding of BCR/ABL junctional peptides to major histocompatibility complex (MHC) class I molecules: Studies in antigen-processing defective cell lines. Leukemia 8:165, 1994
16. Tsomides TJ, Reilly EB, Eisen HN: Anti-melanoma cytotoxic T lymphocytes (CTL) recognize numerous antigenic peptides having self sequences. Int Immunol 9:322, 1997
17. Takamizawa M, Rivas A, Fagoni F, Benike C, Kosek J, Hayakawa H, Engleman G: Dendritic cells that process and present nominal antigens to naïve T lymphocytes are derived from CD2+ precursors. J Immunol 158:2134, 1997
18. Rammensee HG, Friede T, Stevanovic S: MHC ligands and peptidemotifs: First listing. Immunogenetics 41:178, 1995
19. Garcia AC, Scott CA, Brumark A, Carbone FR, Peterson PA, Wilson IA, Teyton L: CD8 enhances formation of stable T-cell receptor/MHC class I molecule complex. Nature 384:518, 1996