Preliminary study on application of impregnated synthetic peptide TLC stationary phases for the pre-screening of 5-HT1A ligands

Biomedical Chromatography

Volumn 17, Issue 5, 2003, Pages 312-317

  Zajdel, Paweł ^a   Bojarski, Andrzej J ^b   Byrtus, Hanna ^a   Chłoń Rzepa, Grazyna ^a   Obniska, Jolanta ^a   Chevallet, Pierre ^c   Martinez, Jean ^c   Pawłowski, Maciej ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c UNIV MONTPELLIER   (France)

Author keywords

5 HT1A receptor affinity; Arylpiperazine derivatives; Binding constants; Biospecific binding; Protein based affinity chromatography

Indexed keywords

AFFINITY CHROMATOGRAPHY; AMINO ACIDS; SILICA GEL;

5-HT1A RECEPTOR AFFINITY; AMINO ACID SEQUENCE; ARYLPIPERAZINE DERIVATIVE; ARYLPIPERAZINES; BINDING CONSTANT; BIOSPECIFIC BINDING; IMPREGNATED SILICAS; PROTEIN-BASED AFFINITY CHROMATOGRAPHY; STATIONARY PHASE; SYNTHETIC PEPTIDE;

PEPTIDES;

1 PHENYLPIPERAZINE DERIVATIVE; ASPARTIC ACID; G PROTEIN COUPLED RECEPTOR; LIGAND; PEPTIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SILICA GEL; TETRAPEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL BOND; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DESIGN; DRUG STRUCTURE; MASS SPECTROMETRY; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

EID: 0043065461     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.224     Document Type: Article

References (25)

1. Andrisano V, Bertucci C, Cavrini V, Recanatini M, Cavalli A, Varoli L, Felix G and Wainer IW. Stereoselective binding of 2,3-substituted 3-hydroxypropionic acids on an immobilized human serum albumin chiral stationary phase: stereochemical characterization and quantitative structure-retention relationship study. Journal of Chromatography A 2000; 876: 75.
2. Baynham MT, Patel S, Moaddel R and Wainer IW. Multidimensional on-line screening for ligands to the α3β4 neuronal nicotinic acetylocholine receptor using an immobilized nicotinic receptor liquid chromatographic stationary phase. Journal of Chromatography B 2002; 772: 155.
3. Brekkan E, Lundqvist A and Lundahl P. Immobilized membrane vesicle or proteoliposome affinity chromatography. Frontal analysis of interactions of cytochalasin B and D-glucose with the human red cell glucose transporter. Biochemistry 1996; 35: 12141.
4. 2A serotonin receptor subtypes. Acta Poloniae Pharmaceutica Drug Research 2000; 57(Suppl): 40.
5. 2A receptor ligands. Archiv der Pharmazie Pharmaceutical and Medicinal Chemistry 1996; 329: 283.
6. 2A receptor ligands. Polish Journal of Pharmacology 2001; 53: 395.
7. Castro B, Dormoy JR, Evin G and Selve C. Réactif de couplage peptidique IV: l'hexafluorophosphate de benzotriazolyloxytrisdimethyl-amino-phosphonium (BOP). Tetrahedron Letters 1975; 16: 1219.
8. 2A receptor activity of new 1-phenylpiperazinylpropyl derivatives with arylalkyl substituents in position 7 of purine-2,6-dione. Polish Journal of Pharmacology 2001; 53: 359.
9. Fassina G. Oriented immobilization of peptide ligands on solid supports. Journal of Chromatography 1992; 591: 99.
10. Garrouste P, Pawłowski M, Tonnaire T, Sicsic S, Dumy P, Rosny E, Reboud-Ravaux M, Fulcrand P and Martinez J. Synthesis and activity of HIV protease inhibitors. European Journal of Medicinal Chemistry 1998; 33: 423.
11. Gordon EM, Barrett RW, Dower WJ, Fodor SPA and Gallop MA. Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions. Journal of Medicinal Chemistry 1994; 37: 1385.
12. 1A receptor agonist and definition of a steric model of this site. European Journal of Medicinal Chemistry 1989; 24: 31.
13. Hoyer D, Hannon JP and Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacology, Biochemistry and Behavior 2002; 71: 533.
14. Jones BJ and Blackburn TP. The medical benefit of 5-HT research. Pharmacology, Biochemistry and Behavior 2002; 71: 555.
15. Kaliszan R. Quantitative Structure-Chromatographic Retention Relationship. Wiley, New York, 1987.
16. Kaliszan R and Wainer IW. Chromatographic Separations Based On Molecular Recognition, Jinno K (ed.). Wiley, New York, 1997; 273.
17. 1A receptor: agonist and antagonist binding sites. Drug Design and Discovery 1994; 11: 231.
18. Moaddel R, Lu L, Baynham M and Wainer IW. Immobilized receptor-and transporter-based liquid chromatographic phases for on-line pharmacological and biochemical studies: a mini-review. Journal of Chromatography B 2002; 768: 41.
19. 1A receptor ligands. Bioorganic and Medicinal Chemistry 1999; 7: 287.
20. 1-acid glycoprotein HPLC column. Biomedical Chromatography 1994; 8: 125.
21. Ooms F. Molecular modeling and computer aided drug design. Examples of their application in medicinal chemistry. Current Medicinal Chemistry 2000; 7: 141.
22. 2A receptor affinity of new 1-phenylpiperazinylpropyl derivatives of purine-2,6- and pyrrolidine-2,5-diones. Il Farmaco, 2000; 55: 461.
23. Yang Q and Lundahl P. Immobilized proteoliposome affinity chromatography for quantitative analysis of specific interactions between solutes and membrane proteins. Interaction of cytochalasin B and D-glucose with the glucose transporter Glutl. Biochemistry 1995; 34: 7289.
24. 1A receptor ligands by TLC on plates impregnated with synthetic peptide. Journal of Planar Chromatography 2002; 15: 38.
25. Zhang Y, Xiao Y, Kellar KJ and Wainer IW. Immobilized nicotinic receptor stationary phase for on-line liquid chromatographic determination of drug-receptor affinities. Analytical Biochemistry 1998; 264: 22.