IL-4 and IL-10 are both required for the induction of oral tolerance

Journal of Immunology

Volumn 162, Issue 5, 1999, Pages 2613-2622

  Rizzo, Luiz Vicente ^a,b   Morawetz, Renate A ^c,e   Miller Rivero, Nancy E ^a   Choi, Rosan ^a   Wiggert, Barbara ^d   Chan, Chi Chao ^a   Morse III, Herbert C ^c   Nussenblatt, Robert B ^a   Caspi, Rachel R ^a  

^a National Eye Institute   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NATIONAL EYE INSTITUTE   (United States)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CYTOKINE PRODUCTION; DESENSITIZATION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; UVEITIS;

ANIMALS; AUTOIMMUNE DISEASES; EYE PROTEINS; FEMALE; IMMUNE TOLERANCE; INTERLEUKIN-10; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RETINOL-BINDING PROTEINS; TRANSFORMING GROWTH FACTOR BETA; UVEITIS;

EID: 0033106370     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Dakin, R. 1829. Remarks on a cutaneous affection, produced by certain poisonous vegetables. Am J. Med. Sci. 4:98.
2. Laissue, J. A., B. Borisch Chappuis, C. Müller, J. C. Reubi, and J.-O. Gebbers. 1993. The intestinal immune system and its relation to disease. Dig. Dis. 11:298.
3. Kagnoff, M. F. 1993. Immunology ot the intestinal tract. Gastroenterology 105: 1275.
4. Mowat, A. M. 1987. The regulation of immune responses to dietary protein antigens. Immunol. Today 8:93.
5. Scott, H., T. S. Halstensen, and P. Brandtzaeg. 1993. The immune system of the gastrointestinal tract. Pediatr. Allergy Immunol. 4(Suppl. 3):7.
6. Keren, D. F. 1992. Antigen processing in the mucosal immune system. Semin. Immunol. 4:217.
7. Nagler-Anderson, C., L. A. Bober, M. E. Robinson, G. W. Siskind, and G. J. Thorbecke. 1986. Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen. Proc. Natl. Acad. Sci. USA 83:7443.
8. Bitar, D., and C. C. Whitacre. 1988. Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell Immunol. 112:364.
9. Nussenblatt, R. B., R. R. Caspi, R. Mahdi, C. C. Chan, F. Roberge, O. Lider, and H. L. Weiner. 1990. Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J. Immunol. 144:1689.
10. Zhang, J. A., L. Davidson, G. Eisenbarth, and H. L. Weiner. 1991. Suppression of diabetes in NOD mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 88:10252.
11. Okumura, S., K. McIntosh, and D. B. Drachman. 1994. Oral administration of acetylcholine receptor: effects on experimental myasthenia gravis. Ann. Neurol. 36:704.
12. Miller, A., O. Lider, and H. L. Weiner. 1991. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med. 174:791.
13. Miller, A., O. Lider, A. al-Sabbagh, and H. L. Weiner. 1992. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species. J. Neuroimmunol. 39:243.
14. Nussenblatt, R. B., I. Gery, H. L. Weiner, F. L. Ferris, J. Schiloach, N. Remaley, C. Perry, R. R. Caspi, D. A. Hafler, S. Foster, et al. 1997. Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. Am. J. Ophthalmol. 123:583.
15. Gregerson, D. S., W. F. Obritsch, and L. A. Donoso. 1993. Oral tolerance in experimental autoimmune uveoretinitis: distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols. J. Immunol. 151:5751.
16. Melamed, D., and A. Friedman. 1993 Modification of the immune response by oral tolerance: antigen requirements and interaction with immunogenic stimuli. Cell. Immunol. 146:412.
17. Chandler, C., and E. Passaro, Jr. 1993. Transplant rejection: mechanisms and treatment. Arch. Surg. 128:279.
18. Friedman, A., and H. L. Weiner. 1994. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA 91:6688.
19. Hancock, W. W., M. H. Sayegh, C. A. Kwok, H. L. Weiner, and C. B. Carpenter. 1993. Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation. Transplantation 55:1112.
20. Rizzo, L. V., N. E. Miller-Rivero, C. C. Chan, B. Wiggert, R. B. Nussenblatt, and R. R. Caspi. 1994. Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J. Clin. Invest. 94:1668.
21. Pepperberg, D. R., T. L. Okajima, B. Wiggert, H. Ripps, R. K. Crouch, and G. J. Chader. 1993. Interphotoreceptor retinoid-binding protein (IRBP): molecular biology and physiological role in the visual cycle of rhodopsin. Mol. Neurobiol. 7:61.
22. Pepperberg, D. R., T. L. Okajima, H. Ripps, G. J. Chader, and B. Wiggert. 1991. Functional properties of interphotoreceptor retinoid-binding protein. Photochem. Photobiol. 54:1057.
23. Rizzo, L. V., R. H. DeKruyff, and D. T. Umetsu. 1992. Generation of B cell memory and affinity maturation: induction with Th1 and Th2 T cell clones. J. Immunol. 148:3733.
24. Chan, C. C., R. R. Caspi, M. Ni, W. C. Leake, B. Wiggert, G. J. Chader, and R. B. Nussenblatt. 1990. Pathology of experimental autoimmune uveoretinitis in mice. J. Autoimmun. 3:247.
25. Ishida, H., R. Hastings, and M. Howard. 1992. Multiple IL-10 antibody treatment blocks the development of Ly-1 lineage B cells. Ann. NY Acad. Sci. 651:264.
26. Denis, M., and E. Ghadirian. 1993. IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections. J. Immunol. 151:5425.
27. Inobe, J. I., Y. Chen, and H. L. Weiner. 1996. In vivo administration of IL-4 induces TGF-β-producing cells and protects animals from experimental autoimmune encephalomyelitis. Ann. NY Acad. Sci. 778:390.
28. Garside, P., M. Steel, E. A. Worthey, A. Satoskar, J. Alexander, H. Bluethmann, F. Y. Liew, and M. Mowat. 1995. T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction. J. Immunol. 154:5649.
29. Aroeira, L. S., F. Cardillo, D. A. De Albuquerque, N. M. Vaz, and J. Mengel. 1995. Anti-IL-10 treatment does not block either the induction or the mainte-nance of orally induced tolerance to OVA. Scand. J. Immunol. 41:319.
30. Fling, S. P., L. A. Donoso, and D. S. Gregerson. 1991. In vitro unresponsiveness to autologous sequences of the immunopathogenic autoantigen, S-antigen. J. Immunol 147:483.
31. Fox, G. M., T. M. Redmond, B. Wiggert, T. Kuwabara, G. J. Chader, and I. Gery. 1987. Dissociation between lymphocyte activation for proliferation and for the capacity to adoptively transfer uveoretinitis. J. Immunol. 138:3242.
32. Caspi, R. R., L. R. Stiff, R. Morawetz, N. E. Miller-Rivero, C.-C. Chan, B. Wiggert, R. B. Nussenblatt, H. Morse III, and L. V. Rizzo. 1996. Cytokine-dependent modulation of tolerance in a murine model of autoimmune uveitis. Ann. NY Acad. Sci. 718:315.
33. Rizzo, L. V. 1994. The subsets of T helper cells involved in the development of experimental autoimmune uveoretinitis. Ophthalmol. McGill 6:5.
34. Suh, E. D., B. P. Vistica, C. C. Chan, J. M. Raber, I. Gery, and R. B. Nussenblatt. 1993. Splenectomy abrogates the induction of oral tolerance in experimental autoimmune uveoretinitis. Curr. Eye Res. 12:833.
35. Morawetz, R. A., L. Gabriele, L. V. Rizzo, N. Noben-Trauth, R. Kuhn, K. Rajewsky, W. Muller, T. M. Doherty, F. Finkelman, R. L. Coffman, et al. 1996. Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse. J. Exp. Med. 184:1651.
36. Horak, I. 1996. Interleukin-2-knockout mice: a new model to study autoimmunity and self-tolerance. Sb. Lek. 97:25.
37. Chen, Y., V. K. Kuchroo, J. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
38. Santos, L. M., A. al-Sabbagh, A. Londono, and H. L. Weiner. 1994. Oral tolerance to myelin basic protein induces regulatory TGF-β-secreting T cells in Peyer's patches of SJL mice. Cell. Immunol. 157:439.
39. Weiner, H. L., J. Inobe, V. Kuchroo, and Y. Chen. 1996. Induction and characterization of TGF-β secreting Th3 cells. FASEB J. 10:A1444.
40. Silva, J. S., D. R. Twardzik, and S. G. Reed. 1991. Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor β (TGF-β). J. Exp. Med. 174:539.
41. Xu, H., L. V. Rizzo, P. B. Silver, and R. R. Caspi. 1997. Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis. Cell. Immunol. 178:69.
42. -/ mice. FASEB J. 10:A1028.
43. Wang, Z.-Y., H. Link, Å. Ljungdahl, B. Höjeberg, J. Link, B. He, J. Qiao, A. Melms, and T. Olsson. 1994. Induction of interferon-γ, interleukin-4, and transforming growth factor-β in rats orally tolerized against experimental autoimmune myasthenia gravis. Cell. Immunol. 157:353.
44. + cells mediate active suppression. J. Immunol. 155:910.
45. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
46. MacDonald, T. T. 1994 Gastrointestinal inflammation: inflammatory bowel disease in knockout mice. Curr. Biol. 4:261.