Dominant expression of CXCR3 is associated with induced expression of IP-10 at hapten-challenged sites of murine contact hypersensitivity: A possible role for interferon-γ-producing CD8+ T cells in IP-10 expression

Journal of Dermatological Science

Volumn 28, Issue 3, 2002, Pages 234-241

  Tokuriki, Atsushi ^a   Seo, Naohiro ^b   Ito, Taisuke ^b   Kumakiri, Masanobu ^a   Takigawa, Masahiro ^b   Tokura, Yoshiki ^b  

^a UNIVERSITY OF FUKUI   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chemokine; Contact hypersensitivity; CXCR3; Hapten; IP 10

Indexed keywords

ALPHA CHEMOKINE; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HAPTEN; MACROPHAGE DERIVED CHEMOKINE; MESSENGER RNA; PROTEIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EAR LOBE; GENE EXPRESSION; GENETIC STRAIN; KERATINOCYTE; LANGERHANS CELL; LYMPH NODE; LYMPHOCYTE; MALE; MAST CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN ALLERGY; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINES, CXC; DERMATITIS, CONTACT; DINITROFLUOROBENZENE; HAPTENS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON TYPE II; LYMPH NODES; MALE; MICE; MICE, INBRED BALB C; PICRYL CHLORIDE; RECEPTORS, CHEMOKINE; RNA, MESSENGER; SKIN;

EID: 0036131157     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(01)00172-4     Document Type: Article

References (32)

1. Biochemical characterization of a γ interferon-inducible cytokine (IP-10)
2. HuMig: A new human member of the chemokine family of cytokines
3. Human IP-9: A keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)
4. Chemokine receptor specific for IP-10 and Mig: Structure, function, and expression in activated T-lymphocytes
5. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
6. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
7. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
8. Th1/Th2 subsets: Distinct differences in homing and chemokine receptor expression?
9. Differential expression of CXCR3 targeting chemokines CXCL10, CXCR9, and CXCL11 in different types of skin inflammation
10. STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13
11. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells
12. A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin
13. Keratinocytes as initiators of inflammation
14. Early molecular events in the induction phase of contact sensitivity
15. Chemokine expression in trinitrochlorobenzene-mediated contact hypersensitivity
16. Interferon-gamma inducible protein (IP-10) expression is mediated by CD8+ T cells and is regulated by CD4+ T cells during the elicitation of contact hypersensitivity
17. Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene
18. The CXCR3 activating chemokines IP-10, Mig, and IP-9 are expressed in allergic but not in irritant patch test reactions
19. Human growth factor (huGRO), interleukin-8 (IL-8) and interferon-gamma-inducible protein (gamma-IP-10) gene expression in cultured normal human keratinocytes
20. Chemokine IP-10 expression in cultured human keratinocytes
21. The expression of a γ interferon-induced protein (IP-10) in delayed immune responses in human skin
22. Epidermal interferon-gamma inducible protein-10 (IP-10) and monokine induced by gamma-interferon (Mig) but not IL-8 mRNA expression is associated with epidermotropism in cutaneous T cell lymphomas
23. IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines
24. Reversal of established delayed type hypersensitivity reactions following therapy with IL-4 or antigen-specific Th2 cells
25. Differential and sequential expression of multiple chemokines during elicitation of allergic contact hypersensitivity
26. Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity
27. Peptide immunization indicates that CD8+ T cells are the dominant effector cells in trinitrophenyl-specific contact hypersensitivity
28. CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity
29. Tumor necrosis factor is a critical mediator in hapten-induced irritant and contact hypersensitivity reactions
30. Biochemical characterization of a γ interferon-inducible cytokine (IP-10)
31. IFN-α and IFN-γ independently stimulate the expression of lipopolysaccharide-inducible genes in murine peritoneal macrophages
32. TNF-α induces cell type and tissue specific expression of chemoattractant cytokines in vivo