Synthesis and evaluation for biological activity of 3-alkyl and 3-halogenoalkyl-quinoxalin-2-ones variously substituted. Part 4

Farmaco

Volumn 57, Issue 1, 2002, Pages 19-25

  Carta, Antonio ^a   Sanna, Paolo ^a   Loriga, Mario ^a   Setzu, Maria Giovanna ^b   La Colla, Paolo ^b   Loddo, Roberta ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b Dipartimento di Biologia Sperimentale   (Italy)

Author keywords

2 Quinoxalinones; Antimicrobial activity; Cytotoxic activity

Indexed keywords

1,2 DIAMINO 3 CHLORO 4 METHOXYBENZENE; 3 BROMOMETHYL 5 CHLOROMETHOXY 2(1H) QUINOXALINONE; 3 BROMOMETHYL 5,6 DICHLORO 2(1H) QUINOXALINONE; 3 BROMOMETHYL 6 CHLORO 2(1H) QUINOXALINONE; 3 BROMOMETHYL 7 CHLORO 2(1H) QUINOXALINONE; 3 BROMOMETHYL 7,8 DICHLORO 2(1H) QUINOXALINONE; 5 AMINO 3,7 BIS(TRIFLUOROMETHYL) 2(1H) QUINOXALINONE; 5 AMINO 7 TRIFLUOROMETHYL 3 ISOPROPYL 2(1H) QUINOXALINONE; 5 CHLORO 6 METHOXY 3 ISOPROPYL 2(1H) QUINOXALINONE; 5 CHLORO 6 METHOXY 3 TRIFLUOROMETHYL 2(1H) QUINOXALINONE; 5,6 DICHLORO 3 ISOPROPYL 2(1H) QUINOXALINONE; 5,6 DICHLORO 3 TRIFLUOROMETHYL 2(1H) QUINOXALINONE; 6 CHLORO 3 ISOPROPYL 2(1H) QUINOXALINONE; 6 CHLORO 3 TRIFLUOROMETHYL 2(1H) QUINOXALINONE; 6 METHOXY 3 TRIFLUOROMETHYL 2(1H) QUINOXALINONE; 7 CHLORO 3 ISOPROPYL 2(1H) QUINOXALINONE; 7 CHLORO 3 TRIFLUOROMETHYL 2(1H) QUINOXALINONE; 7 METHOXY 3 ISOPROPYL 2(1H) QUINOXALINONE; 7,8 DICHLORO 3 ISOPROPYL 2(1H) QUINOXALINONE; 7,8 DICHLORO 3 TRIFLUOROMETHYL 2(1H) QUINOXALINONE; 8 AMINO 3,6 BIS(TRIFLUOROMETHYL) 2(1H) QUINOXALINONE; 8 AMINO 6 TRIFLUOROMETHYL 3 ISOPROPYL 2(1H) QUINOXALINONE; 8 CHLORO 7 METHOXY 3 ISOPROPYL 2(1H) QUINOXALINONE; 8 CHLORO 7 METHOXY 3 TRIFLUOROMETHYL 2(1H) QUINOXALINONE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MINIMUM INHIBITORY CONCENTRATION; STAPHYLOCOCCUS AUREUS;

ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; ANTIVIRAL AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV; HUMANS; LINEAR MODELS; MICROBIAL SENSITIVITY TESTS; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036172881     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01153-3     Document Type: Article

References (11)

1. Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity
2. Synthesis of 3,6,7-substituted-quinoxalin-2-ones for evaluation of antimicrobial and anticancer activity. Part 2
3. Preparation and biological evaluation of 6/7-trifluoromethyl(nitro)-, 6,7-difluoro-3-alkyl(aryl)-substituted-quinoxalin-2-ones. Part 3
4. Trifluoropyruvic acid hydrate in heterocyclic synthesis. Synthesis of trifluoromethylated five, six and seven membered heterocycles with two or more heteroatoms
5. Selective hydrogenation of 2,6-dinitroanilines
6. Structure-activity relationships among 2-substituted 5,6-dichloro-, 4,6-dichloro-, and 4,5-dichloro-1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]benzimidazoles
7. Synthesis of two novel tricyclic rings: Triazolo[4,5-g]-quinolines and pyrido[2,3-g]quinoxalines derived from 6,7-diaminoquinolines
8. Furazan oxides. IV. Extensions of the scope of the haloalkoxy substitution reaction
9. Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines: Novel non nucleoside reverse transcriptase inhibitors of the S-DABO series
10. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
11. Rapid colorimetric assay for cell growth and survival