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1
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0036200852
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+ T cells by infected dendritic cells in vivo
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+ T-cell interactions with DCs during viral infection. The work provides one of the most graphic demonstrations of in vivo T-cell priming during infection.
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+ T-cell interactions with DCs during viral infection. The work provides one of the most graphic demonstrations of in vivo T-cell priming during infection.
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Nat. Immunol.
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Norbury, C.C.1
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2
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-
18644375874
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+ T cells by exogenous cell-associated antigens
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+ T cells. This paper truly drives home the concept that T-cell priming is mediated by DCs and not by pathogen-infected macrophages.
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+ T cells. This paper truly drives home the concept that T-cell priming is mediated by DCs and not by pathogen-infected macrophages.
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Immunity
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Jung, S.1
Unutmaz, D.2
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Sparwasser, T.6
Wu, S.7
Vuthoori, S.8
Ko, K.9
Zavala, F.10
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4
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0037015012
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+ T cell responses to malaria liver stages
-
This paper shows that effective antigen presentation following immunization is of short duration. This result suggests that antigen is rapidly cleared following vaccine administration.
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+ T cell responses to malaria liver stages. Proc. Natl. Acad Sci. USA. 99:2002;11819-11824 This paper shows that effective antigen presentation following immunization is of short duration. This result suggests that antigen is rapidly cleared following vaccine administration.
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Proc. Natl. Acad Sci. USA
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Hafalla, J.C.1
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Zavala, F.5
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5
-
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0037398404
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Feedback regulation of pathogen-specific T cell priming
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By transferring naïve T cells of defined specificity into mice at different times following infection, these investigators show that the duration of in vivo antigen presentation is shorter than the duration of infection. A mechanism for negative feedback regulation of in vivo antigen presentation is presented.
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Wong P., Pamer E.G. Feedback regulation of pathogen-specific T cell priming. Immunity. 18:2003;499-511 By transferring naïve T cells of defined specificity into mice at different times following infection, these investigators show that the duration of in vivo antigen presentation is shorter than the duration of infection. A mechanism for negative feedback regulation of in vivo antigen presentation is presented.
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Immunity
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Wong, P.1
Pamer, E.G.2
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0037083310
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Efficient in vivo presentation of Listeria monocytogenes-derived CD4 and CD8 T-cell epitopes in the absence of IFN-γ
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Skoberne M., Geginat G. Efficient in vivo presentation of Listeria monocytogenes-derived CD4 and CD8 T-cell epitopes in the absence of IFN-γ J. Immunol. 168:2002;1854-1860.
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Skoberne, M.1
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Effect of antigen-processing efficiency on in vivo T-cell response magnitudes
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Vijh S., Pilip I.M., Pamer E.G. Effect of antigen-processing efficiency on in vivo T-cell response magnitudes. J. Immunol. 160:1998;3971-3977.
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+ T-cell memory in response to low, high, and excessive levels of epitope
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+ T-cell memory in response to low, high, and excessive levels of epitope. J. Immunol. 168:2002;4455-4461.
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0035869291
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Intestinal and splenic T-cell responses to enteric Listeria monocytogenes infection: Distinct repertoires of responding CD8 T lymphocytes
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Huleatt J.W., Pilip I., Kerksiek K., Pamer E.G. Intestinal and splenic T-cell responses to enteric Listeria monocytogenes infection: distinct repertoires of responding CD8 T lymphocytes. J. Immunol. 166:2001;4065-4073.
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Huleatt, J.W.1
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12
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0035941095
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Priming of memory but not effector CD8 T cells by a killed bacterial vaccine
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Lauvau G., Vijh S., Kong P., Horng T., Kerksiek K., Serbina N., Tuma R.A., Pamer E.G. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science. 294:2001;1735-1739.
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Lauvau, G.1
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13
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0035889949
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Role of CD28-B7 interactions in generation and maintenance of CD8 T-cell memory
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Suresh M., Whitmire J.K., Harrington L.E., Larsen C.P., Pearson T.C., Altman J.D., Ahmed R. Role of CD28-B7 interactions in generation and maintenance of CD8 T-cell memory. J. Immunol. 167:2001;5565-5573.
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Altman, J.D.6
Ahmed, R.7
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16
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0036918725
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Role of ICOS versus CD28 in antiviral immunity
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Bertram E.M., Tafuri A., Shahinian A., Chan V.S., Hunziker L., Recher M., Ohashi P.S., Mak T.W., Watts T.H. Role of ICOS versus CD28 in antiviral immunity. Eur. J. Immunol. 32:2002;3376-3385.
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Bertram, E.M.1
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Watts, T.H.9
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17
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0037111417
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Inducible costimulator protein controls the protective T-cell response against Listeria monocytogenes
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Mittrucker H.W., Kursar M., Kohler A., Yanagihara D., Yoshinaga S.K., Kaufmann S.H. Inducible costimulator protein controls the protective T-cell response against Listeria monocytogenes. J. Immunol. 169:2002;5813-5817.
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Mittrucker, H.W.1
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19
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0035423265
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4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy
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Cannons J.L., Lau P., Ghumman B., DeBenedette M.A., Yagita H., Okumura K., Watts T.H. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J. Immunol. 167:2001;1313-1324.
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0037090337
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Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T-cell numbers late in the primary response and regulates the size of the T-cell memory response following influenza infection
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+ T-cell responses to viral infection. This result indicates that different co-stimulatory molecules contribute to T-cell responses at distinct times during infection.
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+ T-cell responses to viral infection. This result indicates that different co-stimulatory molecules contribute to T-cell responses at distinct times during infection.
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Bertram, E.M.1
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Cutting edge: Profound defect in T cell responses in TNF-receptor-associated factor 2 dominant-negative mice
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+ T-cell responses
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+ T cells.
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+ T cells.
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Kursar, M.1
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+ T-cell activation
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+ T-cell activation. J. Exp. Med. 195:2002;811-823.
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0037018098
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Estimating the precursor frequency of naive antigen-specific CD8 T cells
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Blattman J.N., Antia R., Sourdive D.J., Wang X., Kaech S.M., Murali-Krishna K., Altman J.D., Ahmed R. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 195:2002;657-664.
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0034889233
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+ T cells without selection of higher-affinity TCR
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+ T cells without selection of higher-affinity TCR. Nat. Immunol. 2:2001;711-717.
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0035348175
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+ T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
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+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2:2001;415-422.
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0035348246
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Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
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van Stipdonk M.J., Lemmens E.E., Schoenberger S.P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2:2001;423-429.
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Cutting edge: Antigen-independent CD8 T cell proliferation
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Wong P., Pamer E.G. Cutting edge: antigen-independent CD8 T cell proliferation. J. Immunol. 166:2001;5864-5868.
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Wong, P.1
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0037074012
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Molecular and functional profiling of memory CD8 T cell differentiation
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+ T cells during the immune response to viral infection. In a surprising twist, these investigators show that memory T cells take a long time to develop.
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+ T cells during the immune response to viral infection. In a surprising twist, these investigators show that memory T cells take a long time to develop.
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Kaech, S.M.1
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H2-M3-restricted memory T cells: Persistence and activation without expansion
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••], and demonstrates that memory-like T-cell responses can be elicited in mice at very early time points following priming.
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Rescue of CD8-T-cell mediated antimicrobial immunity with a nonspecific inflammatory stimulus
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This study demonstrates that the ability of adoptively transferred T cells to confer protective immunity is dramatically prolonged by in vivo stimulation with an agonistic anti-CD40 antibody. This result may have important implications for adoptive T-cell therapy.
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Tuma R.A., Giannino R., Guirnalda P., Leiner I., Pamer E.G. Rescue of CD8-T-cell mediated antimicrobial immunity with a nonspecific inflammatory stimulus. J. Clin. Invest. 110:2002;1493-1501 This study demonstrates that the ability of adoptively transferred T cells to confer protective immunity is dramatically prolonged by in vivo stimulation with an agonistic anti-CD40 antibody. This result may have important implications for adoptive T-cell therapy.
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43
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0037144612
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+-T-cell memory
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+ T cells enhances their ability to become memory cells. This is important because CD40-mediated stimulation was believed to occur predominantly on APCs.
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+ T cells enhances their ability to become memory cells. This is important because CD40-mediated stimulation was believed to occur predominantly on APCs.
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Science
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45
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0036342071
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+ T cells on hematopoietic cells
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+ T cells, specifically those restricted by MHC class Ib molecules, are selected on bone-marrow-derived cells rather than on thymic stromal cells. This may explain some of the functional differences between naïve T cells restricted by different MHC class I molecules.
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+ T cells, specifically those restricted by MHC class Ib molecules, are selected on bone-marrow-derived cells rather than on thymic stromal cells. This may explain some of the functional differences between naïve T cells restricted by different MHC class I molecules.
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+ T-cell populations.
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+ T cells. Proc. Natl. Acad Sci. USA. 98:2001;6313-6318.
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59
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Skewed maturation of memory HIV-specific CD8 T lymphocytes
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Champagne P., Ogg G.S., King A.S., Knabenhans C., Ellefsen K., Nobile M., Appay V., Rizzardi G.P., Fleury S., Lipp M.et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 410:2001;106-111.
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Champagne, P.1
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60
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0036109159
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+ T cells vary in differentiation phenotype in different persistent virus infections
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This study characterizes memory T-cell populations in patients following different chronic viral infections. Interestingly, the degree of memory T-cell maturation differs depending upon the viral pathogen.
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+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8:2002;379-385 This study characterizes memory T-cell populations in patients following different chronic viral infections. Interestingly, the degree of memory T-cell maturation differs depending upon the viral pathogen.
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Appay, V.1
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63
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0036919199
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