Apoptosis Induction by Wheat-flour Sphingoid Bases in DLD-1 Human Colon Cancer Cells

Bioscience, Biotechnology and Biochemistry

Volumn 66, Issue 10, 2002, Pages 2228-2231

  Sugawara, Tatsuya ^a   Kinoshita, Mikio ^b   Ohnishi, Masao ^b   Miyazawa, Teruo ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

Author keywords

Apoptosis; Colon cancer; Sphingoid bases; Wheat flour

Indexed keywords

SPHINGIODEA; TRITICUM AESTIVUM;

ANTINEOPLASTIC AGENT; DNA; DRUG DERIVATIVE; SPHINGOSINE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; CHROMATIN; COLON TUMOR; DRUG EFFECT; FLOUR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PATHOLOGY; ULTRASTRUCTURE; WHEAT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL NUCLEUS; CHROMATIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONIC NEOPLASMS; DNA, NEOPLASM; FLOUR; HUMANS; SPHINGOSINE; TRITICUM; TUMOR CELLS, CULTURED;

EID: 0042900399     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.66.2228     Document Type: Article

References (25)

1. Lynch, D. V., Sphingolipids. In “Lipid metabolism in plants”, ed. Moore, T. S., Jr., CRC Press Inc., Florida, pp. 285-308 (1993).
2. Sugawara, T., and Miyazawa, T., Separation and determination of glycolipids from edible plant sources by high-performance liquid chromatography and evaporative light-scattering detection. Lipids, 34, 1231-1237 (1999).
3. Dillehay, D. L., Webb, S. K., Schmelz, E. M., and Merrill, A. H., Jr., Dietary sphingomyelin inhibits I, 2-dimethylhydrazine-induced colon cancer in CF1 mice. J. Nutr., 124, 615-620 (1994).
4. Schmelz, E. M., Dillehay, D. L., Webb, S. K., Reiter, A., Adams, J., and Merrill, A. H., Jr., Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis. Cancer Res., 56, 4936-4941 (1996).
5. Schmelz, E. M., Bushnev, A. S., Dillehay, D. L., Liotta, D. C., and Merrill, A. H., Jr., Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones. Nutr. Cancer, 28, 81-85 (1997).
6. Spiegel, S., and Merrill, A. H., Jr., Sphingolipid metabolism and cell growth regulation. FASEB J., 10, 1388-1397 (1996).
7. Igarashi, Y., Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines: in regard to membrane sphingolipid signaling pathways. J. Biochem., 122, 1080-1087 (1997).
8. Ohta, H., Sweeney, E. A., Masamune, A., Yatomi, Y., Hakomori, S., and Igarashi, Y., Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res., 55, 691-697 (1995).
9. Sweeney, E. A., Sakakura, C., Shirahama, T., Masamune, A., Ohta, H., Hakomori, S., and Igarashi, Y., Sphingosine and its methylated derivative N, N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Int. J. Cancer, 66, 358-366 (1996).
10. Hung, W. C., Chang, H. C., and Chuang, L. Y., Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells. Biochem. J., 338, 161-166 (1999).
11. Vesper, H., Schmelz, E. M., Nikolova-Karakashian, M. N., Dillehay, D. L., Lynch, D. V., and Merrill, A. H., Jr., Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J. Nutr., 129, 1239-1250 (1999).
12. Gaver, R. C., and Sweeley, C. C., Methods for methanolysis of sphingolipids and direct determination of long-chain bases by gas chromatography. J. Am. Oil Chem. Soc., 42, 294-298 (1965).
13. Ohnishi, M., Ito, S., and Fujino, Y., Characterization of sphingolipids in spinach leaves. Biochim. Biophys. Acta, 752, 416-422 (1983).
14. Lauter, C. J., and Trams, E. G., A spectrophotomet-ric determination of sphingosine. J. Lipid Res., 3, 136-138 (1962).
15. Igarashi, M., and Miyazawa, T., Newly recognized cytotoxic effect of conjugated trienoic fatty acids on cultured human tumor cells. Cancer Lett., 148, 173-179 (2000).
16. Igarashi, M., and Miyazawa, T., Do conjugated ei-cosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? Biochem. Biophys. Res. Commun., 270, 649-656 (2000).
17. Harada-Shiba, M., Kinoshita, M., Kamido, H., and Shimokado, K., Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. J. Biol. Chem., 273, 9681-9687 (1998).
18. Sweeney, E. A., Inokuchi, J., and Igarashi, Y., Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide. FEBS Lett., 425, 61-65 (1998).
19. Sakakura, C., Sweeney, E. A., Shirahama, T., Hakomori, S., and Igarashi, Y., Suppression of Bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. FEBS Lett., 379, 177-180 (1996).
20. L gene expression. FEBS Lett., 407, 97-100 (1997).
21. Kojima, M., Ohnishi, M., and Ito, S., Composition and molecular species of ceramide and cerebroside in scarlet runner beans (Phaseolus coccineus L.) and kidney beans (Phaseolus vulgaris L.). J. Agric. Food Chem., 39, 1709-1714 (1991).
22. Nilsson, A., Metabolism of sphingomyelin in the intestinal tract of the rat. Biochim. Biophys. Acta, 164, 575-584 (1968).
23. Schmelz, E. M., Crall, K. J., Larocque, R., Dillehay, D. L., and Merrill, A. H., Jr., Uptake and metabolism of sphingolipids in isolated intestinal loops of mice. J. Nutr., 124, 702-712 (1994).
24. Nyberg, L., Nilsson, A., Lundgren, P., and Duan, R. D., Localization and capacity of sphingomyelin digestion in the rat intestinal tract. J. Nutr. Biochem., 8, 112-118 (1997).
25. Nilsson, A., Metabolism of cerebroside in the intestinal tract of the rat. Biochem. Biophys. Acta, 187, 113-121 (1969).