A model of sensitivity: 1,3-Butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene

Environmental and Molecular Mutagenesis

Volumn 42, Issue 2, 2003, Pages 106-110

  Wickliffe, Jeffrey K ^a   Ammenheuser, Marinel M ^a   Salazar, James J ^a   Abdel Rahman, Sherif Z ^a   Hastings Smith, Darlene A ^a   Postlethwait, Edward M ^a,b   Lloyd, R Stephen ^a   Ward Jr , Jonathan B ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Butadiene; Comet; Gene knockout; Genetic sensitivity; Hprt; Microsomal epoxide hydrolase

Indexed keywords

1,2 EPOXY 3 BUTENE; 1,3 BUTADIENE; BUTADIENE DIEPOXIDE; ENZYME; EPOXIDE HYDROLASE; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DETOXIFICATION; DNA DAMAGE; FEMALE; GENETIC POLYMORPHISM; GENOME; GENOTOXICITY; MALE; MICROSOME; MOUSE; MUTATION RATE; NONHUMAN;

ADMINISTRATION, INHALATION; ANIMALS; BUTADIENES; COMET ASSAY; DNA DAMAGE; DRUG RESISTANCE; EPOXIDE HYDROLASES; EPOXY COMPOUNDS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INJECTIONS, INTRAPERITONEAL; MICE; MICE, KNOCKOUT; MUTATION;

EID: 0042735298     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10181     Document Type: Article

References (22)

1. Abdel-Rahman SZ, Ammenheuser MM, Ward JB Jr. 2001. Human sensitivity to 1,3-butadiene: role of microsomal epoxide hydrolase polymorphisms. Carcinogenesis 22:415-423.
2. Abdel-Rahman SZ, El-Zein RA, Ammenheuser MM, Yang Z, Stock TH, Morandi M, Ward JB Jr. 2003. Variability in human sensitivity to 1,3-butadiene: influence of the allelic variants of the microsomal epoxide hydrolase gene. Environ Mol Mutagen 41:140-146.
3. Ammenheuser MM, Bechtold WE, Abdel-Rahman SZ, Rosenblatt JI, Hastings-Smith DA, Ward JB Jr. 2001. Assessment of 1,3-butadiene exposure in polymer production workers using hprt mutation in lymphocytes as a biomarker. Environ Health Perspect 109:1249-1255.
4. Anderson D, Dobrzynka MM, Jackson LI, Yu TW, Brinkworth MH. 1997. Somatic and germ cell effects in rats and mice after treatment with 1,3-butadiene and its metabolites, 1,2-epoxybutene and 1,2,3,4diepoxybutane. Mutat Res 391:233-242.
5. Cochrane JE, Skopek TR. 1994. Mutagenicity of butadiene and its epoxide metabolites. II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3FI mice. Carcinogenesis 15:719-723.
6. Hassett C, Aicher L, Sidhu JS, Omiecinski CJ. 1994. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum Mol Genet 3:421-428.
7. Hassett C, Lin J, Carty CL, Laurenzana EM, Omiecinski CJ. 1997. Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression. Arch Biochem Biophys 337:275-283.
8. Huff JE, Melnick RL, Solleveld HA, Haseman JK, Powers M, Miller RA. Multiple organ carcinogenicity of 1,3-butadiene in B6C3FI mice after 60 weeks of inhalation exposure. Science 227:548-549.
9. IARC. 1999. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 71. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. Lyon, France: IARC. p 109.
10. Jackson MA, Stack HF, Rice JM, Waters MD. 2000. A review of the genetic and related effects of 1,3-butadiene in rodents and humans. Mutat Res 463:181-123.
11. Ma H, Wood TG, Ammenheuser MM, Rosenblatt JI, Ward JB Jr. 2000. Molecular analysis of hprt mutant lymphocytes from 1,3-butadiene-exposed workers. Environ Mol Mutagen 36:59-71.
12. Meng Q, Recio L, Reilly AA, Wong B, Bauer B, Walker VE. 1998a. Comparison of the mutagenic potency of 1,3-butadiene at the Hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats. Carcinogenesis 19:1019-1027.
13. Meng Q, Skopek TR, Walker DM, Hurley-Leslie S, Chen T, Zimmer DM, Walker VE. 1998b. Culture and propagation of Hprt mutant T-lymphocytes isolated from mouse spleen. Environ Mol Mutagen 32:236-243.
14. Meng Q, Henderson RF, Chen T, Heflich RH, Walker DM, Bauer MJ, Reilly AA, Walker VE. 1999a. Mutagenicity of 1,3-butadiene at the Hprt locus of T-lymphocytes following inhalation exposure of female mice and rats. Mutat Res 429:107-125.
15. Meng Q, Henderson RF, Walker DM, Bauer MJ, Reilly AA, Walker VE. 1999b. Mutagenicity of the racemic mixtures of butadiene monoepoxide and butadiene diepoxide at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats. Mutat Res 429:127-140.
16. Meng Q, Singh N, Heflich RH, Bauer MJ, Walker VE. 2000. Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane. Mutat Res 464:169-184.
17. Miyata M, Kudo G, Lee Y-H, Yang TJ, Gelboin HV, Fernandez-Salguero P, Kimura S, Gonzalez FJ. 1999, Targeted disruption of the microsomal epoxide hydrolase gene: microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J Biol Chem 274:23963-23968.
18. Sinal CJ, Miyata M, Tohkin M, Nagata K, Bend JR, Gonzalez FJ. 2000. Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem 275:40504-40510.
19. Skopek TR, Walker VE, Cochrane JE, Craft TR, Cariello NF. 1982. Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to n-ethyl-n-nitrosourea. Proc Natl Acad Sci USA 89:7866-7870.
20. Recio L, Steen A-M, Pluta LJ, Meyer KG, Saranko CJ. 2001. Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms. Chem Biol Interact 136-136:325-341.
21. Ward JB Jr, Ammenheuser MM, Whorton EB Jr, Bechtold WE, Kelsey KT, Legator MS. 1996. Biological monitoring for mutagenic effects of occupational exposure to butadiene. Toxicology 113:84-90.
22. Ward JB Jr, Abdel-Rahman SZ, Henderson RF, Stock TH, Morandi M, Rosenblatt JI, Ammenheuser MM. 2001. Assessment of butadiene exposure in synthetic rubber manufacturing workers in Texas using frequencies of hprt mutant lymphocytes as a biomarker. Chem Biol Interact 135-136:465-483.