Comparison of the mutagenic potency of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats

Carcinogenesis

Volumn 19, Issue 6, 1998, Pages 1019-1027

  Meng, Quanxin ^a,b   Recio, Leslie ^c   Reilly, Andrew A ^a,b   Wong, Brian A ^c   Bauer, Michael ^a,b   Walker, Vernon E ^a,b  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BUTADIENE; ALKYLATING AGENT; CONCANAVALIN A; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTERLEUKIN 2; TIOGUANINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL MUTAGENESIS; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE LOCUS; MARKER GENE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; SPLEEN; STATISTICAL ANALYSIS; T LYMPHOCYTE; THYMUS;

ANIMALS; BUTADIENES; CELLS, CULTURED; FEMALE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INHALATION EXPOSURE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MUTAGENS; PHENOTYPE; RATS; RATS, INBRED F344; T-LYMPHOCYTES;

EID: 0031878243     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.6.1019     Document Type: Article

References (52)

1. Melnick,R.L. and Kohn,M.C. (1995) Mechanistic data indicate that 1,3-butadiene is a human carcinogen. Carcinogenesis, 16, 157-163.
2. Landrigan,P.J. (1993) Critical assessment of epidemiological studies on the carcinogenicity of 1,3-butadiene and styrene. In Sorsa,M., Peltonen,K., Vainio,H. and Hemminki,K. (eds) Butadiene and Styrene: Assessment of Health Hazards, vol. 127. IARC, Lyon, pp. 375-388.
3. Bond,J.A., Recio,L. and Andjelkovich,D. (1995) Epidemiological and mechanistic data suggest that 1,3-butadiene will not be carcinogenic to humans at exposures likely to be encountered in the environment or workplace. Carcinogenesis, 16, 165-171.
4. Downs,T.D., Crane,M.M. and Kim,K.W. (1987) Mortality among workers at a 1,3-butadiene facility. Am. J. Ind. Med., 13, 311-329.
5. Divine,B.J., Wendt,J.K. and Hartman,C.M. (1993) Cancer mortality among workers at a butadiene production facility. In Sorsa,M., Peltonen,K., Vainio,H. and Hemminki,K. (eds) Butadiene and Styrene: Assessment of Health Hazards, vol. 127. IARC, Lyon, pp. 345-362.
6. Divine,B.J. and Hartman,C.M. (1996) Mortality update of butadiene production workers. Toxicology, 113, 169-181.
7. Delzell,E., Sathiakumar,N., Hovinga,M., Macaluso,M., Julian,J., Larson,R., Cole,P. and Muir,D.C.F. (1996) A follow-up study of synthetic rubber workers. Toxicology, 113, 182-189.
8. Macaluso,M., Larson,R., Delzell,E., Sathiakumar,N., Hovinga,M., Julian,J., Muir,D. and Cole,P. (1996) Leukemia and cumulative exposure to butadiene, styrene and benzene among workers in the synthetic rubber industry. Toxicology, 113, 190-202.
9. Jacobson-Kram,D. and Rosenthal,S.L. (1995) Molecular and genetic toxicology of 1,3-butadiene. Mutat. Res., 339, 121-130.
10. Himmelstein,M.W., Acquavella,J.P, Recio,L., Medinsky,M.A. and Bond,J.A. (1997) Toxicology and epidemiology of 1,3-butadiene. CRC Rev. Toxicol., 27, 1-108.
11. Cunningham,M.J., Choy,W.N., Arce,G.T., Rickard,L.B., Vlachos,D.A., Kinney,L.A. and Sariff,A.M. (1986) In vivo sister chromatid exchange and micronucleus induction studies with 1,3-butadiene in B6C3F1 mice and Sprague-Dawley rats. Mutagenesis, 1, 449-452.
12. Sorsa,M., Autio,K., Demopoulos,N.A., Järventaus,H., Rössner,P., S̈crám,R.J., Staphanou,G. and Vlachodimitropoulòs,D. (1994) Human cytogenetic biomonitoring of occupational exposure to 1,3-butadiene. Mutat. Res., 309, 321-326.
13. Tates,A.D., Dam,F.J., Zwart,F.A., et al. (1996) Biological effect monitoring in the industrial workers from the Czech Republic exposed to low levels of butadiene. Toxicology, 113, 91-99.
14. Sorsa,M., Osterman-Golkar,S., Peltonen,K., Saarikoski,S.T. and S̈crám,R. (1996) Assessment of exposure to butadiene in the process industry. Toxicology, 113, 77-83.
15. S̈crám,R.J., Rössner,P., Peltonen,K., Podrazilová,K., Mracková,G., Demopoulos,N.A., Stephanou,G., Vladimiropoulos,D., van Dam,F.J., and Tales,A.D. (1998) Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1,3-butadiene exposed workers. Mutat. Res., in press.
16. Cochrane,J.E. and Skopek,T.R. (1994) Mutagenicity of butadiene and its epoxide metabolites. II: mutational spectrum of butadiene, 1,2-epoxybutene and diepoxybulane at the hprt locus in splenic T cells from exposed B6C3F1 mice. Carcinogenesis, 15, 719-723.
17. Tates,A.D., van Dam,F.J., de Zwart,F.A., van Teylingen,C.M.M. and Natarajan,A.T. (1994) Development of a cloning assay with high cloning efficiency to detect induction of 6-thioguanine-resistant lymphocytes in spleen of adult mice following in vivo inhalation exposure to 1,3-butadiene. Mutat. Res., 309, 299-306.
18. Ward,J.B. Jr, Ammenheuser,M.M., Bechtold,W.E., Whorton,E.B. Jr and Legator,M.S. (1994) Hprt mutant lymphocyte frequencies in workers at a 1,3-butadiene production plant. Environ. Health Perspect., 102, 79-85.
19. Ward,J.B. Jr, Ammenheuser,M.M., Bechtold,W.E., Whorton,E.B. Jr and Legator,M.S. (1996) Assessment of butadiene exposure in a rubber plant using a urine metabolite and HPRT mutant frequency as biological markers of exposure and effect. Environ. Mol. Mutagen., 27 (Suppl. 27), 73.
20. Ward,J.B. Jr, Ammenheuser,M.M., Whorton,E.B. Jr, Bechtold,W.E., Kelsey,K.T. and Legator,M.S. (1996) Biological monitoring for mutagenic effects of occupational exposures to butadiene. Toxicology, 113, 84-90.
21. Sisk,S., Pluta,L.J., Bond,J.A. and Recio,L. (1994) Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene. Carcinogenesis, 15, 471-477.
22. Recio,L., Meyer,K.G., Pluta,L.J., Moss,O.R. and Saranko,C.J. (1996) Assessment of 1,3-butadiene mutagenicity in bone marrow of B6C3F1 lacI transgenic mice (Big Blue): a review of mutational spectrum and lacI mutant frequency after a 5-day 625 ppm 1,3-butadiene exposure. Environ. Mal. Mutagen., 28, 424-429.
23. Birnbaum,L.S. and Keller,D. (1996) Metabolism and pharmacokinetics of 1,3-butadiene. Toxicology, 113, 14-16.
24. Skopek,T.R., Walker,V.E., Cochrane,J.E., Craft,T.R. and Cariello,N.F. (1992) Mutational spectrum of N-ethyl-N-nitrosourea at the hprt locus in splenic T-cells of exposed B6C3F1 mice. Proc. Natl Acad. Sci. USA, 89, 7866-7870.
25. Walker,V.E. and Skopek,T.R. (1993) A mouse model for the study of in vivo mutational spectra: Sequence specificity of ethylene oxide at the hprt locus. Mutat. Res., 288, 151-162.
26. Paulson,A.S. and Delehanty,T.A. (1982) Sensitivity analysis in experimental design. In Heiner,K.W., Sacher,R.S. and Wilkinson,J.W. (eds) Computer Science and Statistics: Proceedings of the 14th Symposium on the Interface. Springer-Verlag, New York, pp. 52-57.
27. Press,W.H., Flannery,B.P, Teukolsky,S.A. and Vetterling,W.T. (1992) Numerical recipes. The Art of Scientific Computing. Cambridge University Press, New York.
28. Hollander,M. and Wolfe,D.A. (1973) Nonparametric Statistical Methods. John Wiley & Sons, New York, p. 71.
29. Walker,V.E., Sisk,S.C., Upton,P.B., Wong,B.A. and Recio,L. (1997) In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure. Mutat. Res., 392, 211-222.
30. Walker,V.E., Andrews,J.L., Clement,N.L., Upton,P.B., deBoer,J.G., Sussman,H.E. and Gorelick,N.J. (1998) Detection of cyclophosphamide-induced mutations at the hprt but not the lacI locus in splenic lymphocytes of exposed mice. Cancer Res. (submitted).
31. Aidoo,A., Lyn-Cook,L.E., Mittelstaedt,P.A., Heflich,R.H. and Casciano,D.A. (1991) Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rat following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. Environ. Mol. Mutagen., 17, 141-151.
32. Walker,V.E. and Skopek,T.R. (1993) Age-dependent relationships between exposures and phenotypic expression of hprt mutations in T-cells from mice treated with N-ethyl-N-nitrosourea. Environ. Mol. Mitagen., 21 (Suppl. 22), 75.
33. Huff,J.E., Melnick,R.L., Solleveld,H.A., Haseman,J.K., Powers,M. and Miller,R.A. (1985) Multiple organ carcinogenicity of 1,3-butadiene in B6C3F1 mice after 60 weeks of inhalation exposure. Science, 227, 548-549.
34. Melnick,R.L., Huff,J., Chou,B.J. and Miller,R. (1990) Carcinogenicity of 1,3-butadiene in C57BL/6XC3H F1 mice at low exposure concentrations. Cancer Res., 50, 6592-6599.
35. Recio,L. and Meyer,K.G. (1995) Increased frequency of mutations at A:T base pairs in the bone marrow of B6C3F1 lacI transgenic mice exposed to 1,3-butadiene. Environ. Mol. Mutagen., 26, 1-8.
36. Mittelstaedt,R.A., Smith,B.A. and Helfich,R.H. (1995) Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes. Environ. Mol. Mutagen., 26, 261-269.
37. Owen,P.E., Glaiser,J.R., Gaunt,I.F. and Pullinger,D.H. (1987) Inhalation toxicity studies with 1,3-hutadiene.3. Two-year toxicity/carcinogenicity studies in rats. Am. Ind. Hyg. Assoc. J., 48, 407-413.
38. Jones,I.M., Burkhart-Schultz,K., Strout,C.L. and Crippen,T.L. (1987) Factors that affect the frequency of thioguanine-resistant lymphocytes in mice following exposure to ethylnitrosourea. Environ. Mutagen., 9, 317-329.
39. Walker,V.E. and Walker,D.M. (1997) Mutagenicity at the hprt locus of T-cells following drinking water exposures of F344 rats to acrylonitrile. Toxicologist, 36, 308.
40. Hirokawa,K. and Makinodan,T. (1975) Thymic involution: effect on T cell differentiation. J. Immunol., 114, 1659-1664.
41. Sollay,R.G., Butcher,E.C. and Weissman,I.L. (1980) Thymus cell migration: quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immunol., 10, 210-218.
42. Meng,Q., Henderson,R.F., Reilly,A.A., Bauer,M. and Walker,V.E. (1998) Relative contribution of epoxybutene versus diepoxybutane to the mutagenicity of butadiene following inhalation exposures of mice and rats. Toxicologist, 42, 182.
43. Meng,Q. and Walker,V.E. (1998) Propagation of hprt mutant T-lymphocytes from mice exposed to 1,3-butadiene. Environ. Mol. Mutagen., 31, (Suppl. 29), 46.
44. Chen,T., Aidoo,A., Casciano,D.A. and Heflich,R.H. (1998) Expansion of ral 6-thioguanine-resistant T-lymphocyte clones by stimulation with ionomycin and a phorbol ester. Environ. Mol. Mutagen., 31, 97-102.
45. Crippen,T.L. and Jones,I.M. (1989) Cell proliferation in the bone marrow, thymus and spleen of mice studied by continuous, in vivo bromodeoxcytidine labelling and flow cytometric analysis. Cell Tissue Kinet., 22, 203-212.
46. Himmelstein,M.W., Turner,M.J., Asgharian,B. and Bond,J.A. (1994) Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation. Carcinogenesis, 15, 1479-1486.
47. Himmelstein,M.W., Asgharian,B. and Bond,J.A. (1995) High concentrations of butadiene epoxides in livers and lungs of mice compared to rats exposed to 1,3-butadiene. Toxicol. Appl. Pharmacol., 132, 281-288.
48. Himmelstein,M.W., Turner,M.J., Asgharian,B. and Bond,J.A. (1996) Metabolism of 1,3-butadiene: inhalation pharmacokinetics and tissue dosimetry of butadiene epoxides in rats and mice. Toxicology, 113, 306-309.
49. Thornton-Manning,J.R., Dahl,A.R., Bechtold,W.E., Griffith,W.C., Jr and Henderson,R.F. (1995) Disposition of butadiene monoepoxide and butadiene diepoxide in various tissues of rats and mice following a low-level inhalation exposure to 1,3-butadiene. Carcinogenesis, 16, 1723-1731.
50. Thornton-Manning,J.R., Dahl,A.R., Bechtold,W.E., Griffith,W.C., Jr, Pei,L. and Henderson,R.F. (1995) Gender differences in the metabolism of 1,3-butadiene in Sprague-Dawley rats following a low-level inhalation exposure. Carcinogenesis, 16, 2875-2878.
51. Thornton-Manning,J.R., Dahl,A.R., Bechtold,W.E. and Henderson,R.F. (1996) Gender and species differences in the metabolism of 1,3-butadiene to butadiene monoepoxide and butadiene diepoxide in rodents following low-level inhalation exposures. Toxicology, 113, 322-325.
52. Henderson,R.F., Thornton-Manning,J.R., Bechtold,W.E. and Dahl,A.R. (1996) Metabolism of 1,3-butadiene: species differences. Toxicology, 113, 17-22.