Heme oxygenase is expressed in human pulmonary artery smooth muscle where carbon monoxide has an anti-proliferative role

European Journal of Pharmacology

Volumn 473, Issue 2-3, 2003, Pages 135-141

  Stanford, Salome J ^a,b   Walters, Matthew J ^a   Hislop, Alison A ^b   Haworth, Sheila G ^b   Evans, Timothy W ^a   Mann, Brian E ^c   Motterlini, Roberto ^d   Mitchell, Jane A ^a,e  

^a ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^e IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Carbon monoxide; Carbon monoxide releasing molecule; Heme oxygenase; Pulmonary artery smooth muscle cell, human; Pulmonary hypertension

Indexed keywords

CARBON MONOXIDE; DIMER; HEME OXYGENASE; HEME OXYGENASE 1; HEME OXYGENASE 2; OXIDIZING AGENT; TRICARBONYLDICHLORORUTHENIUM; UNCLASSIFIED DRUG;

ARTERY MUSCLE; ARTICLE; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; LUNG BLOOD VESSEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0042707875     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)02001-6     Document Type: Article

References (23)

1. 2 complexes (x=1-3). Inorg. Chem. 34:1995;4722-4734.
2. Carraway M.S., Ghio A.J., Taylor J.L., Piantadosi C.A. Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. Am. J. Physiol. 275:1998;L583-L892.
3. Carraway M.S., Ghio A.J., Suliman H.B., Carter J.D., Whorton A.R., Piantadosi C.A. Carbon monoxide promotes hypoxic pulmonary vascular remodelling. Am. J. Physiol., Lung Cell. Mol. Physiol. 282:2002;L693-L702.
4. Durante W. Carbon monoxide and bile pigments: surprising mediators of vascular function. Vasc. Med. 7:2002;195-202.
5. Durante W. Heme oxygenase-1 in growth control and its clinical application to vascular disease. J. Cell. Physiol. 195:2003;373-382.
6. Fujiwara N., Okado A., Seo H.G., Fujii J., Kondo K., Taniguchi N. Quinazoline derivatives suppress nitric oxide production by macrophages through inhibition of NOS II gene expression. FEBS Lett. 395:1996;299-303.
7. Homer K.L., Fiore S.A., Wanstall J.C. Inhibition by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) of responses to nitric oxide-donors in rat pulmonary artery: influence of the mechanism of nitric oxide generation. J. Pharm. Pharmacol. 51:1999;135-139.
8. Hussain A.S., Marks G.S., Brien J.F., Nakatsu K. The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate. Can. J. Physiol. Pharm. 75:1997;1034-1037.
9. Jourdan K.B., Evans T.W., Lamb N.J., Goldstraw P., Mitchell J.A. Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth muscle cells: species variation. Am. J. Respir. Cell Mol. Biol. 21:1999;105-110.
10. Kitamura Y., Matsuoka Y., Nomura Y., Taniguchi T. Induction of inducible nitric oxide synthase and heme oxygenase-1 in rat glial cells. Life Sci. 62:1998;1717-1721.
11. Lin H., McGrath J.J. Vasodilating effects of carbon monoxide. Drug Chem. Toxicol. 11:1988;371-385.
12. Minamino T., Christou H., Hsieh C.M., Liu Y., Dhawan V., Abraham N.G., Perella M.A., Mitsialis S.A., Kourembanas S. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc. Natl. Acad. Sci. U. S. A. 98:2001;8798-8803.
13. Mitchell J.A., Akarasereenont P., Thiemermann C., Flower R.J., Vane J.R. Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. U. S. A. 90:1993;11693-11697.
14. Morita T., Perrella M.A., Lee M.E., Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc. Natl. Acad. Sci. 92:1995;1475-1479.
15. Motterlini R., Clark J.E., Foresti R., Sarathchandra P., Mann B.E., Green C.J. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ. Res. 90:2002;E17-E24.
16. Peyton K.J., Reyna S.V., Chapman G.B., Ensenat D., Lin X.M., Wang H., Schafer A.I., Durante W. Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth. Blood. 99:2002;4443-4448.
17. Song R., Mahidhara R.S., Liu F., Ning W., Otterbein L.E., Choi A.M. Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Am. J. Respir. Cell Mol. Biol. 27:2002;603-610.
18. Stanford S.J., Gitlin J.M., Mitchell J.A. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. Br. J. Pharmacol. 133:2001;825-832.
19. Taille C., Almolki A., Benhamed M., Zedda C., Megret J., Berger P., Leseche G., Fadel E., Yamaguchi T., Marthan R., Aubier M., Boczkows J. Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation. J. Biol. Chem. 2003;. (epub ahead of print).
20. Visner G.A., Lu F., Zhou H., Liu J., Kazemfar K., Agarwal A. Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin. Circulation. 107:2003;911-916.
21. Willis D., Moore A.R., Frederick R., Willoughby D.A. Heme oxygenase: a novel target for the modulation of the inflammatory response. Nat. Med. 2:1996;87-90.
22. Wort S.J., Woods M., Warner T.D., Evans T.W., Mitchell J.A. Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: relevance to pathogenesis of pulmonary hypertension and vascular remodeling. Am. J. Respir. Cell Mol. Biol. 25:2001;104-110.
23. Zakhary R., Gaine S.P., Dinerman J.L., Flavahan N.A., Snyder S.H. Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation. Proc. Natl. Acad. Sci. 93:1996;795-798.