The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 8, 1997, Pages 1034-1037

  Hussain, Aman S ^a   Marks, Gerald S ^a   Brien, James F ^a   Nakatsu, Kanji ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

1H 1,2,4 oxadiazolo 4,3 a quinoxalin 1 one (ODQ); Carbon monoxide; Nitric oxide; Rabbit aorta rings; Soluble guanylyl cyclase

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CARBON MONOXIDE; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA; CARBON MONOXIDE; ENZYME INHIBITORS; GUANYLATE CYCLASE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITROGLYCERIN; OXADIAZOLES; QUINOXALINES; RABBITS;

EID: 0030687622     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjpp-75-8-1034     Document Type: Article

References (1)

1. Bolotina, V.M., Najibi, S., Palacino, J.J., Pagano, P.J., and Cohen, R.A. 1994. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature (London), 368: 850-853.