Fos family members: Regulation, structure and role in oncogenic transformation

Histology and Histopathology

Volumn 15, Issue 3, 2000, Pages 921-928

  Tulchinsky, E ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

AP 1; Fos; Fra 1; Fra 2; Neoplastic transformation

Indexed keywords

ONCOPROTEIN; PROTEIN C FOS; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR FRA 1; TRANSCRIPTION FACTOR FRA 2; UNCLASSIFIED DRUG;

CARCINOGENESIS; HISTOPATHOLOGY; MALIGNANT TRANSFORMATION; NONHUMAN; ONCOGENE; ONCOGENE C FOS; ONCOGENE RAS; ONCOGENE SRC; PROTEIN STRUCTURE; REVIEW; TRANSACTIVATION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; TUMOR GROWTH;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; DNA-BINDING PROTEINS; FOS-RELATED ANTIGEN-2; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-FOS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

GALLUS GALLUS; MURINAE; RODENTIA;

EID: 0033925204     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

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4. Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro
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12. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
13. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
14. Alterations in epithelial polarity and the pathogenesis of desease states
15. A novel transformation-relevant activation domain in Fos proteins
16. cFos: A key regulator of osteoclast-macrophage lineage determination and bone remodelling
17. Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity
18. Carcinogenesis: A balance between β-catenin and APC
19. Fos-transformation activates genes associated with invasion
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21. Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes
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23. Deregulation of genes encoding microfilament-associated proteins during Fos-induced morphological transformation
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25. AP-1 function and regulation
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27. Lessons from hereditary colorectal cancer
28. The jun and fos protein families are both required for cell cycle progression in fibroblasts
29. Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: Differential role of Fos proteins
30. Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells
31. Essential functions of ezrin in maintenance of cell shape and lamellopodial extension in normal and transformed fibroblasts
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33. Suppression of c-Fos gene transcription with malignant transformation of human bronchial epithelial cells
34. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
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38. Target genes of β-catenin-T cell factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
39. Transformation by ras modifies AP-1 composition and activity
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41. c-Fos activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein
42. A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth
43. Activation of β-catenin signaling in colon cancer by mutations in β-catenin or APC
44. Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins
45. Phosphorylation and high level expression of Fra-2 in v-src transformed cells: A pathway of activation of endogenous AP-1
46. Fra-2-positive autoregulatory loop triggered by mitogen-activated protein kinase (MAPK) and Fra-2 phosphorylation sites by MAPK
47. A naturally occuring truncated form of FosB that inhibits Fos/Jun transcriptional activity
48. Mutagenesis of the DNA contact site in Fos protein: Compatibility with the scissors grip model and requirement for transformation
49. Isolation and characterization of fra-2, an additional member of the fos gene family
50. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
51. Cross family interaction between the bHLHZip USF and bZIP Fra1 proteins results in down-regulation of AP-1 activity
52. Induction of apoptosis by c-Fos protein
53. Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion
54. Transition from SCLC to NSCLC phenotype is accompanied by an increased TRE-binding activity and recruitment of specific AP-1 proteins
55. Stabilization of β-catenin by genetic defects in melanoma cell lines
56. Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins
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58. c-fos is required for malignant progression of skin tumors
59. Structure and chromosomal assignment of the mouse fra-1 gene, and its exclusion as a candidate gene for oc (osteosclerosis)
60. 2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases
61. Transcriptional activation and transformation by FosB protein require phosphorylation of the carboxyl-terminal activation domain
62. fra-2 promoter can respond to serum-stimulation through AP-1 complexes
63. Conserved motifs in Fos and Jun define a new class of activation domain
64. Difference in transcriptional regulatory function between c-Fos and Fra-2
65. Analysis of AP-1 function in cellular transformation pathways
66. The serum response element
67. Ternary complex factors: Growth factor regulated transcriptional activators
68. Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases
69. Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction, which is dependent on the HMGI-C gene product
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71. Transformation by Fos proteins requires a C-terminal transactivation domain
72. Gene expression profiles in normal and cancer cells