Mutagenesis of the runt domain defines two energetic hot spots for heterodimerization with the core binding factor β subunit

Journal of Biological Chemistry

Volumn 278, Issue 35, 2003, Pages 33097-33104

  Zhang, Lina ^a   Li, Zhe ^a   Yan, Jiangli ^b   Pradhan, Padmanava ^b   Corpora, Takeshi ^b   Cheney, Matthew D ^a   Bravo, Jerónimo ^c,d   Warren, Alan J ^c   Bushweller, John H ^b   Speck, Nancy A ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOASSAY; DIMERIZATION; DISEASE CONTROL; MUTAGENESIS;

TRANSCRIPTION FACTORS;

GENES;

CORE BINDING FACTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING AFFINITY; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME REARRANGEMENT; COMPLEX FORMATION; DIMERIZATION; DNA BINDING; ENERGY TRANSFER; EPITHELIUM CELL; GENE MUTATION; GENETIC TRANSFECTION; HEMATOPOIESIS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STOMACH MUCOSA; STRUCTURE ANALYSIS;

ALANINE; ANIMALS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CORE BINDING FACTOR ALPHA SUBUNITS; DIMERIZATION; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA PROTEINS; KINETICS; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; SPECTROMETRY, FLUORESCENCE; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; TRANSFECTION; UREA;

ANIMALIA;

EID: 0042377360     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303972200     Document Type: Article

References (68)

1. Ogawa, E., Inuzuka, M., Maruyama, M., Satake, M., Naito-Fujimoto, M., Ito, Y., and Shigesada, K. (1993) Virology 194, 314-331
2. Ogawa, E., Maruyama, M., Kagoshima, H., Inuzuka, M., Lu, J., Satake, M., Shigesada, K., and Ito, Y. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6859-6863
3. Wang, S., Wang, Q., Crute, B. E., Melnikova, I. N., Keller, S. R., and Speck, N. A. (1993) Mol. Cell. Biol. 13, 3324-3339
4. Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., and Downing, J. R. (1996) Cell 84, 321-330
5. Wang, Q., Stacy, T., Binder, M., Marín-Padilla, M., Sharpe, A. H., and Speck, N. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 3444-3449
6. Wang, Q., Stacy, T., Miller, J. D., Lewis, A. F., Huang, X., Bories, J.-C., Bushweller, J. H., Alt, F. W., Binder, M., Marín-Padilla, M., Sharpe, A., and Speck, N. A. (1996) Cell 87, 697-708
7. Sasaki, K., Yagi, H., Bronson, R. T., Tominaga, K., Matsunashi, T., Deguchi, K., Tani, Y., Kishimoto, T., and Komori, T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12359-12363
8. Rubnitz, J. E., and Look, A. T. (1998) Curr. Opin. Hematol. 5, 264-270
9. Speck, N. A., and Gilliland, D. G. (2002) Nat. Rev. Cancer 2, 502-513
10. Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W. H., Beddington, R. S. P., Mundlos, S., Olsen, B. R., Selby, P. B., and Owen, M. J. (1997) Cell 89, 765-772
11. Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S., and Kishimoto, T. (1997) Cell 89, 755-764
12. Kundu, M., Javed, A., Jeon, J.-P., Horner, A., Shum, L., Eckhaus, M., Muenke, M., Lian, J. B., Yang, Y., Nuckolls, G. H., Stein, G. S., and Liu, P. P. (2002) Nat. Genet. 32, 639-644
13. Miller, J., Stacy, T., Lowrey, C., and Speck, N. A. (2002) Nat. Genet. 32, 645-649
14. Yoshida, C. A., Furuichi, T., Fujita, T., Fukuyama, R., Kanatani, N., Kobayashi, S., Satake, M., Takada, K., and Komori, T. (2002) Nat. Genet. 32, 633-638
15. Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., Owen, M. J., Mertelsmann, R., Zabel, B. U., and Olsen, B. R. (1997) Cell 89, 773-780
16. Li, Q.-L., Ito, K., Sakakura, C., Fukamachi, H., Inoue, K., Chi, X.-Z., Lee, K.-Y., Nomura, S., Lee, C.-W., Han, S.-B., Kim, H.-M., Kim, W.-J., Yamamoto, H., Yamashita, N., Yano, T., Ikeda, T., Itohara, S., Inazawa, J., Abe, T., Hagiwara, A., Yamagishi, H., Ooe, A., Kaneda, A., Sugimura, T., Ushijima, T., Bae, S.-C., and Ito, Y. (2002) Cell 109, 113-124
17. Levanon, D., Bettoun, D., Harris-Cerruti, C., Woolf, E., Negreanu, V., Eilam, R., Bernstein, Y., Goldenberg, D., Xiao, C., Fliegauf, M., Kremer, E., Otto, F., Brenner, O., Lev-Tov, A., and Groner, Y. (2002) EMBO J. 21, 3454-3456
18. Inoue, K., Ozaki, S., Shiga, T., Ito, K., Masuda, T., Okado, N., Iseda, T., Kawaguchi, S., Ogawa, M., Bae, S. C., Yamashita, N., Itohara, S., Kudo, N., and Ito, Y. (2002) Nat. Neurosci. 5, 946-954
19. Taniuchi, I., Osato, M., Egawa, T., Sunshine, J. J., Bae, S.-C., Komori, T., Ito, Y., and Littman, D. R. (2002) Cell 111, 621-633
20. Kagoshima, H., Shigesada, K., Satake, M., Ito, Y., Miyoshi, H., Ohki, M., Pepling, M., and Gergen, J. P. (1993) Trends Genet. 9, 338-341
21. Meyers, S., Downing, J. R., and Hiebert, S. W. (1993) Mol. Cell. Biol. 13, 6336-6345
22. Nagata, T., Gupta, V., Sorce, D., Kim, W.-Y., Sali, A., Chait, B. T., Shigesada, K., Ito, Y., and Werner, M. H. (1999) Nat. Struct. Biol. 6, 615-619
23. Berardi, M., Sun, C., Zehr, M., Abildgaard, F., Peng, J., Speck, N. A., and Bushweller, J. H. (1999) Struct. Fold Des. 7, 1247-1256
24. Rudolph, M. J., and Gergen, J. P. (2001) Nat. Struct. Biol. 8, 384-386
25. Tahirov, T. H., Inoue-Bungo, T., Morii, H., Fujikawa, A., Sasaki, M., Kimura, K., Shiina, M., Sato, K., Kumasaka, T., Yamamoto, M., Ishii, S., and Ogata, K. (2001) Cell 104, 755-767
26. Bravo, J., Li, Z., Speck, N. A., and Warren, A. J. (2001) Nat. Struct. Biol. 8, 371-377
27. Golling, G., Li, L.-H., Pepling, M., Stebbins, M., and Gergen, J. P. (1996) Mol. Cell. Biol. 16, 932-942
28. Tang, Y.-Y., Crute, B. E., Kelley, J. J., III, Huang, X., Yan, J., Shi, J., Hartman, K. L., Laue, T. M., Speck, N. A., and Bushweller, J. H. (2000) FEBS Lett. 470, 167-172
29. Nagata, T., and Werner, M. H. (2001) J. Mol. Biol. 308, 191-203
30. Bartfeld, D., Shimon, L., Couture, G. C., Rabinovich, D., Frolow, F., Levanon, D., Groner, Y., and Shakked, Z. (2002) Structure 10, 1395-1407
31. Warren, A. J., Bravo, J., Williams, R. L., and Rabbitts, T. H. (2000) EMBO J. 19, 3004-3115
32. Bäckström, S., Wolf-Watz, M., Grundström, C., Härd, T., Grundström, T., and Sauer, U. H. (2002) J. Mol. Biol. 322, 259-272
33. Tang, Y.-Y., Shi, J., Zhang, L., Davis, A., Bravo, J., Warren, A. J., Speck, N. A., and Bushweller, J. H. (2000) J. Biol. Chem. 275, 39579-39588
34. Goger, M., Gupta, V., Kim, W.-Y., Shigesada, K., Ito, Y., and Werner, M. H. (1999) Nat. Struct. Biol. 6, 620-623
35. Li, Z., Yan, J., Matheny, C. J., Corpora, T., Bravo, J., Warren, A. J., Bushweller, J. H., and Speck, N. A. (2003) J. Biol. Chem. 278, 33088-33096
36. Bae, S. C., Yamaguchi-Iwai, Y., Ogawa, E., Maruyama, M., Inuzuka, M., Kagoshima, H., Shigesada, K., Satake, M., and Ito, Y. (1993) Oncogene 8, 809-814
37. Crute, B. E., Lewis, A. F., Wu, Z., Bushweller, J. H., and Speck, N. A. (1996) J. Biol. Chem. 271, 26251-26260
38. Santoro, M. M., and Bolen, D. W. (1988) Biochemistry 27, 8063-8068
39. Bullock, A. N., Henckel, J., DeDecker, B. S., Johnson, C. M., Nikolova, P. V., Proctor, M. R., Lane, D. P., and Fersht, A. R. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 14338-14442
40. Panda, M., and Horowitz, P. M. (2000) J. Protein Chem. 19, 399-409
41. Huang, X., Crute, B. E., Sun, C., Tang, Y.-Y., Kelley, J. J., III, Lewis, A. F., Hartman, K. L., Laue, T. M., Speck, N. A., and Bushweller, J. H. (1998) J. Biol. Chem. 273, 2480-2487
42. Lewis, A. F., Stacy, T., Green, W., Taddesse-Heath, L., Hartley, J. W., and Speck, N. A. (1999) J. Virol. 73, 5535-5547
43. Gu, T.-L., Goetz, T. L., Graves, B. J., and Speck, N. A. (2000) Mol. Cell. Biol. 20, 91-103
44. Krimpenfort, P., de Jong, R., Uematsu, Y., Dembic, Z., Ryser, S., von Boehmer, H, Steinmetz, M., and Berns, A. (1988) EMBO J. 7, 745-750
45. Sun, W., Graves, B. J., and Speck, N. A. (1995) J. Virol. 69, 4941-4949
46. Nordeen, S. K. (1988) BioTechniques 6, 454-457
47. Wells, J. A. (1991) Methods Enzymol. 202, 390-411
48. Perez-Alvarado, G. C., Munnerlyn, A., Dyson, H. J., Grosschedl, R., and Wright, P. E. (2000) FEBS Lett. 470, 125-130
49. Huang, X., Peng, J. W., Speck, N. A., and Bushweller, J. H. (1999) Nat. Struct. Biol. 6, 624-627
50. Hsiang, Y. H., Spencer, D., Wang, S., Speck, N. A., and Raulet, D. H. (1993) J. Immunol. 150, 3905-3916
51. Wotton, D., Ghysdael, J., Wang, S., Speck, N. A., and Owen, M. J. (1994) Mol. Cell. Biol. 14, 840-850
52. Bae, S.-C., Ogawa, E., Maruyama, M., Oka, H., Satake, M., Shigesada, K., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Ito, Y. (1994) Mol. Cell. Biol. 14, 3242-3252
53. Kanno, T., Kanno, Y., Chen, L.-F., Ogawa, E., Kim, W.-Y., and Ito, Y. (1998) Mol. Cell. Biol. 18, 2444-2454
54. Clackson, T., and Wells, J. A. (1995) Science 267, 383-386
55. Bogan, A. S., and Thorn, K. S. (1998) J. Mol. Biol. 280, 1-9
56. Ma, B., Wolfson, H. J., and Nussinov, R. (2001) Curr. Opin. Struct. Biol. 11, 364-369
57. DeLano, W. L. (2002) Curr. Opin. Struct. Biol. 12, 14-20
58. Cho, Y., Gorina, S., Jeffrey, P. D., and Pavletich, N. P. (1994) Science 265, 346-355
59. Gallivan, J. P., and Dougherty, D. A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9459-9464
60. DeLano, W. L., Ultsch, M. H., de Vos, A. M., and Wells, J. A. (2000) Science 287, 1279-1283
61. Liu, P., Tarle, S. A., Hajra, A., Claxton, D. F., Marlton, P., Freedman, M., Siciliano, M. J., and Collins, F. S. (1993) Science 261, 1041-1044
62. Castilla, L. H., Wijmenga, C., Wang, Q., Stacy, T., Speck, N. A., Eckhaus, M., Marin-Padilla, M., Collins, F. S., Wynshaw-Boris, A., and Liu, P. P. (1996) Cell 87, 687-696
63. Lutterbach, B., Hou, Y., Durst, K. L., and Hiebert, S. W. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 12822-12827
64. Cao, W., Britos-Bray, M., Claxton, D. F., Kelley, C. A., Speck, N. A., Liu, P. P., and Friedman, A. D. (1997) Oncogene 15, 1315-1327
65. Adja, N., Stacy, T., Speck, N. A., and Liu, P. P. (1998) Mol. Cell. Biol. 18, 7432-7443
66. Durst, K. L., Lutterbach, B., Kummalue, T., Friedman, A. D., and Hiebert, S. W. (2003) Mol. Cell. Biol. 23, 607-619
67. Lukasik, S., Zhang, L., Corpora, T., Tomanicek, S., Li, Y., Kundu, M., Hartman, K., Liu, P. P., Laue, T. M., Biltonen, R. L., Speck, N. A., and Bushweller, J. H. (2002) Nat. Struct. Biol. 9, 674-679
68. Chen, C.-Z., and Shapiro, R. (1999) Biochemistry 38, 9273-9285