Lipase TL-mediated kinetic resolution of 5-benzyloxy-1-tert-butyldimethylsilyloxy-2-pentanol at low temperature: Concise asymmetric synthesis of both enantiomers of a piperazic acid derivative

Journal of Organic Chemistry

Volumn 68, Issue 18, 2003, Pages 6899-6904

  Aoyagi, Yutaka ^a   Saitoh, Yoshihiro ^a   Ueno, Tasuku ^a   Horiguchi, Mai ^a   Takeya, Koichi ^a   Williams, Robert M ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; REACTION KINETICS; SYNTHESIS (CHEMICAL);

KINETIC RESOLUTION;

ORGANIC COMPOUNDS;

2,4 DIMETHYLPYRIDINE; 2,6 DIMETHYLPYRIDINE; 5 BENZYLOXY 1 TERT BUTYLDIMETHYLSILYLOXY 2 PENTANOL; AMINO ACID; BASE; BENZOIN; PIPERAZIC ACID DERIVATIVE; PYRIDINE; TRIACYLGLYCEROL LIPASE; TRIETHYLAMINE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; CHEMICAL REACTION KINETICS; DRUG STRUCTURE; ENANTIOMER; ISOMER; LOW TEMPERATURE PROCEDURES;

AMINES; CANDIDA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLD; DEALKYLATION; HYDROGEN; INDICATORS AND REAGENTS; KINETICS; LIPASE; MOLECULAR CONFORMATION; OSMIUM TETROXIDE; OXIDATION-REDUCTION; PENTANOLS; PYRIDAZINES; SILANES; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0042338587     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo034441n     Document Type: Article

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