Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity

Journal of Antibiotics

Volumn 52, Issue 5, 1999, Pages 466-473

  Sanglier, Jean Jacques ^a   Quesniaux, Valerie ^a   Fehr, Theodor ^a   Hofmann, Hans ^a   Mahnke, Marion ^a   Memmert, Klaus ^a   Schuler, Walter ^a   Zenke, Gerhard ^a   Gschwind, Liliane ^a   Maurer, Claudine ^a   Schilling, Wolfgang ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN; CYCLOPHILIN A; CYCLOSPORIN A; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; MACROLIDE; SANGLIFEHRIN A; SANGLIFEHRIN B; SANGLIFEHRIN C; SANGLIFEHRIN D; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; FERMENTATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TAXONOMY;

STREPTOMYCES;

EID: 0032971829     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.52.466     Document Type: Article

References (20)

1. DREYFUSS, M.; E. HÄRRI, H. HOFFMANN, H. KOBEL, W. FACHE & H. TSCHERTER: Cyclosporin A and C, new metabolites from Trichoderma polysporum (Link et Pers.) Rifai. Eur. J. Appl. Microbiol. 3:125-133, 1976
2. HANDSCHUMACHER, R. E.; M. W. HARDING, J. RICE & R. J. DRUGGE: Cyclophilin: a specific cytosolic binding protein for Cyclosporin A. Science 286: 544-547, 1984
3. LIU, J.; J. D. FARMER, W. S. LANE, J. FRIEDMAN, I. WEISSMAN & S. L. SCHREIBER: Calcineurine is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-814, 1991
4. FRIEDMAN, J. & I. WEISSMAN: Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA. Cell 66: 799-806, 1991
5. SCHREIBER, S. L.: Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 283: 283-287, 1991
6. SIEKIERKA, J. J.; S. H. Y. HUNG, M. POE, C. S. LIN & N. H. SIGAL: A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distict from cyclophilin. Nature 341: 755-757, 1989
7. TOCCI, M. J.; D. A. MATKOVICH, K. A. KWOK, P. F. DUMONT, S. LIN, S. DEGUDICIBUS, J. J. SIEKIERKA, J. CHIN & N. I. HUTCHISON: The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J. Immunol. 143: 718-726, 1989
8. s6k. EMBO J. 16: 3693-3704, 1997
9. SEHGAL, S.: Rapamune (Sirolimus, Rapamycin): An overview and mechanism of action. Ther. Drug Monitoring 17: 660-665, 1995
10. FEHR, T.; V. F. QUESNIAUX, J .-J. SANGLIER, L. OBERER, L. GSCHWIND, M. PONELLE, W. SCHILLING, S. WEHRLI, A. ENZ, G. ZENKE & W. SCHULER: Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes. J. Antibiotics 50:893-899, 1997
11. SHIRLING, E. B. & D. GOOTLIEB: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313-340, 1966
12. STANECK, J. L. & G. D. ROBERTS: Simplified approach to identification of aerobic actinomycetes by thin-layer chromatography. Appl. Microbiol. 28: 226-231, 1974
13. O'DONNELL, A. G., D. E. MINNIKIN & M. GOODFELLOW: Integrated lipid and wall actinomycetes In Chemical Methods in Bacterial Systematics. Eds., GOODFELLOW, M. & D. E. MINNIKIN, Academic Press, London, pp. 131-144, 1985
14. QUESNIAUX, V. F.; S. WEHRLI, C. STEINER, J. JOERGENSEN, H. J. SCHUURMAN, P. HERRMANN, M. H. SCHREIER & W. SCHULER: The immunosuppressant rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo. Blood 84: 1543-1552, 1994
15. SCHNEIDER, H.; N. CHARARA, R. SCHMITZ, S. WEHRLI, M. G. M. ZURINI, V. F. J. QUESNIAUX & N. R. MOVVA: Primary structure, tissue distribution and determination of binding specifity for cyclosporins. Biochemistry 33: 8218-8224, 1994
16. STRONG, D. M.; A. A. AHMED, G. B. THURMAN, & K. W. SELL: In vitro stimulation of murine spleen cells using a microculture system and a multiple automated sample harvester. J. Immunol. Methods 2: 279-287, 1973
17. MEO, T.: The MLR in the mouse. In Immunological Methods, Ed., L. LEFKOVITS and B. PERNIS, pp. 227-239, Academic Press, N.Y., 1979
18. FEHR, T.; J. KALLEN, L. OBERER, J.-J. SANGLIER & W. SCHILLING: Sanglifehrins A, B, C and D, novel cyclophilin binding compounds isolated from Streptomyces sp. A92-308110. II Structure elucidation, stereochemistry and physico-chemical properties. J. Antibiotics 52: 474-479, 1999
19. CLIPSTONE, N. A. & G.R. CRABTREE: Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357: 695-697, 1992
20. O'KEEFE, S. J.; J. TAMURA, R. L. KINCAID, M. J. TOCCI & E. A. O'NEILL: FK-506-and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357: 692-694, 1992