Enhancement of the Enantioselectivity in Lipase-Catalyzed Kinetic Resolutions of 3-Phenyl-2H-azirine-2-methanol by Lowering the Temperature to -40°C

Journal of Organic Chemistry

Volumn 62, Issue 15, 1997, Pages 4906-4907

  Sakai, Takashi ^a   Kawabata, Isamu ^a   Kishimoto, Tetsuo ^a   Ema, Tadashi ^a   Utaka, Masanori ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRIACYLGLYCEROL LIPASE;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; COST EFFECTIVENESS ANALYSIS; ENANTIOMER; ENZYME ACTIVITY; ENZYME MECHANISM; PSEUDOMONAS; RACEMIC MIXTURE; STEREOCHEMISTRY; TEMPERATURE SENSITIVITY;

EID: 0030800148     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo970581j     Document Type: Article

References (39)

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34. Lipases showing the E values > 3 (origin, E value, fast-reacting enantiomer): CHIRAZYME L-2 (Candida antarctica, 8, R),CHIRAZYME L-7 (poreine pancreas, 6, R), lipase AK (Pseudomonas fluorescens, 4, R).
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36. 2O (11), benzene (9), cyclohexane (9), n-hexane (7).
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38. When the temperature was decreased below -40°C, the lipase might begin to lose the conformational flexibility essential for the catalytic activity.
39. Lipase exhibits a high catalytic activity on heating at 100°C: Zaks, A.; Klibanov, A. M. Science 1984, 224, 1249.