GE3, a novel hexadepsipeptide antitumor antibiotic produced by Streptomyces sp. II. Structure determination

Journal of Antibiotics

Volumn 50, Issue 8, 1997, Pages 704-708

  Agatsuma, Tsutomu ^a   Sakai, Yasushi ^a   Mizukami, Tamio ^a   Saitoh, Yutaka ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; DEPSIPEPTIDE; GE 3; UNCLASSIFIED DRUG;

CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SHORT SURVEY;

EID: 0030828995     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.704     Document Type: Short Survey

References (13)

1. SAKAI, Y.; T. YOSHIDA, T. TSUJITA, K. OCHIAI, T. AGATSUMA, Y. SAITOH, F. TANAKA, T. AKIYAMA, S. AKINAGA & T. MIZUKAMI: GE3, a novel hexadepsipeptide antitumor antibiotic, produced by Streptomyces sp. I. Taxonomy, production, isolation, physico-chemical properties, and biological activities. J. Antibiotics 50: 659-664, 1997
2. MAEHR, H.; C. LIU, N. J. PALLERONI, J. SMALLHEER, L. TODARO, T. H. WILLIAMS & J. F. BLOUNT: Microbial products. VIII. Azinothricin, a novel hexadepsipeptide antibiotic. J. Antibiotics 39: 17-25, 1986
3. HURLEY, T. R.; R. H. BUNGE, N. E. WILLMER, G. C. HOKANSON & J. C. FRENCH: PD 124,895 and PD 124,966, two new antitumor antibiotics. J. Antibiotics 39: 1651-1656, 1986
4. SMITKA, T. M.; J. B. DEETER, A. H. HUNT, F. P. MERTZ, R. M. ELLIS, L. D. BOECK & R. C. YAO: A83586C, a new depsipeptide antibiotic. J. Antibiotics 41: 726-733, 1988
5. NAKAGAWA, M.; Y. HAYAKAWA, K. ADACHI & H. SETO: A new depsipeptide antibiotic, variapeptin. Agric. Biol. Chem. 54: 791-794, 1990
6. HAYAKAWA, Y.; M. NAKAGAWA, Y. TODA & H. SETO: A new depsipeptide antibiotic, citropeptin. Agric. Biol. Chem. 54: 1007-1011, 1990
7. NAKAGAWA, M.; Y. HAYAKAWA, K. FURIHATA & H. SETO: Structural studies on new depsipeptide antibiotics, variapeptin and citropeptin. J. Antibiotics 43: 477-484, 1990
8. HENSENS, O. D.; R. P. BORRIS, L. R. KOUPAL, C. G. CALDWELL, S. A. CURRIE, A. A. HAIDRI, C. F. HOMNICK, S. S. HONEYCUTT, S. M. LINDENMAYER, C. D. SCHWARTZ, B. A. WEISSBERGER, H. B. WOODRUFF, D. L. ZINK, L. ZITANO, J. M. FIELDHOUSE, T. ROLLINS, M. S. SPRINGER & J. P. SPRINGER: L-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from Streptomyces sp. MA6348. Fermentation, isolation and structure determination. J. Antibiotics 44: 249-254, 1991
9. NISHIYAMA, Y.; K. SUGAWARA, K. TOMITA, H. YAMAMOTO, H. KAMEI & T. OKI: Verucopeptin, a new antitumor antibiotic active against B16 melanoma. I. Taxonomy, production, isolation, physico-chemical properties and biological activity. J. Antibiotics 46: 921-927, 1993
10. SUGAWARA, K.; S. TODA, T. MORIYAMA, M. KONISHI & T. OKI: Verucopeptin, a new antitumor antibiotic active against B16 melanoma. II. Structure determination. J. Antibiotics 46: 928-935, 1993
11. UENO, M.; M. AMEMIYA, T. SOMENO, T. MASUDA, H. IINUMA, H. NAGANAWA, M. HAMADA, M. ISHIZUKA & T. TAKEUCHI: IC101, extracellular matrix antagonist produced by Streptomyces sp. MJ202-72F3. Production, isolation, structure determination and biological activity. J. Antibiotics 46: 1658-1665, 1993
12. GRÄFE, U.; R. SCHLEGEL, M. RITZAU, W. IHN, K. DORNBERGER, C. STENGEL, W. F. FLECK, W. GUTSCHE, A. HÄRTL & E. F. PAULUS: Aurantimycins, new depsipeptide antibiotics from Streptomyces aurantiacus IMET 43917. Production, isolation, structure elucidation, and biological activity. J. Antibiotics 48: 119-125, 1995
13. DALBY, S.; G. W. KENNER & R. C. SHEPPARD: Peptides. Part X. β-Hydroxyleucine. J. Chem. Soc. 1960: 968-973, 1960