DNA immunization with the cysteine-rich interdomain region 1 of the Plasmodium falciparum variant antigen elicits limited cross-reactive antibody responses

Infection and Immunity

Volumn 71, Issue 8, 2003, Pages 4536-4543

  Baruch, Dror I ^a   Gamain, Benoit ^a   Miller, Louis H ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS REACTING ANTIBODY; CYSTEINE; DNA; DNA VACCINE; ERYTHROCYTE MEMBRANE PROTEIN 1; HYPERIMMUNE GLOBULIN; MALARIA VACCINE; MEMBRANE ANTIGEN; PARASITE ANTIGEN; PLASMID DNA; POOLED HUMAN HYPERIMMUNE GLOBULIN; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN SC Y179; UNCLASSIFIED DRUG; VARIANT ANTIGEN;

ADOLESCENT; ANIMAL CELL; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN EXPRESSION; ANTIGENIC VARIATION; ARTICLE; CHO CELL; CROSS REACTION; CYSTEINE RICH INTERDOMAIN REGION 1; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEMAGGLUTINATION; IMMUNITY; IMMUNIZATION; MOUSE; NONHUMAN; PLASMID; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DOMAIN; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CHO CELLS; CRICETINAE; CROSS REACTIONS; FEMALE; HEMAGGLUTINATION; MALARIA VACCINES; MICE; MICE, INBRED BALB C; PLASMIDS; PLASMODIUM FALCIPARUM; VACCINES, DNA;

EID: 0042265108     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.8.4536-4543.2003     Document Type: Article

References (48)

1. Aguiar, J. C., R. C. Hedstrom, W. O. Rogers, Y. Charoenvit, J. B. Sacci, Jr., D. E. Lanar, V. F. Majam, R. R. Stout, and S. L. Hoffman. 2001. Enhancement of the immune response in rabbits to a malaria DNA vaccine by immunization with a needle-free jet device. Vaccine 20:275-280.
2. Barragan, A., P. G. Kremsner, W. Weiss, M. Wahlgren, and J. Carlson. 1998. Age-related buildup of humoral immunity against epitopes for rosette formation and agglutination in African areas of malaria endemicity. Infect. Immun. 66:4783-4787.
3. Baruch, D. I., B. Gamain, J. W. Barnwell, J. S. Sullivan, A. Stowers, G. G. Galland, L. H. Miller, and W. E. Collins. 2002. Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line. Proc. Natl. Acad. Sci. USA 99:3860-3865.
4. Baruch, D. I., X. C. Ma, H. B. Singh, X. Bi, B. L. Pasloske, and R. J. Howard. 1997. Identification of a region of PfEMP1 that mediates adherence of Plasmodium falciparum infected erythrocytes to CD36: conserved function with variant sequence. Blood 90:3766-3775.
5. Baruch, D. I., S. J. Rogerson, and B. M. Cooke. 2002. Asexual blood stages of malaria antigens: cytoadherence. Chem Immunol. 80:144-162.
6. Beeson, J. G., and G. V. Brown. 2002. Pathogenesis of Plasmodium falciparum malaria: the roles of parasite adhesion and antigenic variation. Cell Mol. Life Sci. 59:258-271.
7. Beeson, J. G., J. C. Reeder, S. J. Rogerson, and G. V. Brown. 2001. Parasite adhesion and immune evasion in placental malaria. Trends Parasitol. 17:331-337.
8. Bull, P. C., M. Kortok, O. Kai, F. Ndungu, A. Ross, B. S. Lowe, C. I. Newbold, and K. Marsh. 2000. Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age. J. Infect. Dis. 182:252-259.
9. Bull, P. C., B. S. Lowe, N. Kaleli, F. Njuga, M. Kortok, A. Ross, F. Ndungu, R. W. Snow, and K. Marsh. 2002. Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan children. J. Infect. Dis. 185:1688-1691.
10. Bull, P. C., B. S. Lowe, M. Kortok, and K. Marsh. 1999. Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants. Infect. Immun. 67:733-739.
11. Bull, P. C., B. S. Lowe, M. Kortok, C. S. Molyneux, C. I. Newbold, and K. Marsh. 1998. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria. Nat. Med. 4:358-360.
12. Bull, P. C., and K. Marsh. 2002. The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria. Trends Microbiol. 10:55-58.
13. Chen, Q., M. Schlichtherle, and M. Wahlgren. 2000. Molecular aspects of severe malaria. Clin. Microbiol. Rev. 13:439-450.
14. Doolan, D. L., and S. L. Hoffman. 2001. DNA-based vaccines against malaria: status and promise of the multi-stage malaria DNA vaccine operation. Int. J. Parasitol. 31:753-762.
15. Doolan, D. L., and S. L. Hoffman. 2002. Nucleic acid vaccines against malaria. Chem. Immunol. 80:308-321.
16. Fang, Z., Y. W. Liu, Y. K. Shi, X. B. Yu, W. Q. Huang, and X. Ji. 2002. The humoral immune responses elicited in mice by inoculations with a recombinant protein or DNA based on the circumsporozoite-protein gene of Plasmodium falciparum. Ann. Trop. Med. Parasitol. 96:463-468.
17. Fried, M., and P. E. Duffy. 1996. Adherence of Plasmodium falcipanim to chondroitin sulfate A in the human placenta. Science 272:1502-1504.
18. Fried, M., and P. E. Duffy. 2002. Two DBLgamma subtypes are commonly expressed by placental isolates of Plasmodium falciparum. Mol. Biochem. Parasitol. 122:201-210.
19. Fried, M., F. Nosten, A. Brockman, B. J. Brabin, and P. E. Duffy. 1998. Maternal antibodies block malaria. Nature 395:851-852.
20. Fukumoto, T., N. Torigoe, S. Kawabata, M. Murakami, T. Uede, T. Nishi, Y. Ito, and K. Sugimura. 1998. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation. Nat. Biotechnol. 16:267-270.
21. Gamain, B., S. Gratepanche, L. H. Miller, and D. I. Baruch. 2002. Molecular basis for the dichotomy in Plasmodium falciparum adhesion to CD36 and chondroitin sulfate A. Proc. Natl. Acad. Sci. USA 99:10020-10024.
22. Gamain, B., L. H. Miller, and D. I. Baruch. 2001. The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes. Proc. Natl. Acad. Sci. USA 98:2664-2669.
23. Gamain, B., J. D. Smith, L. H. Miller, and D. I. Baruch. 2001. Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36. Blood 97:3268-3274.
24. Gupta, S., R. W. Snow, C. A. Donnelly, K. Marsh, and C. Newbold. 1999. Immunity to non-cerebral severe malaria is acquired after one or two infections. Nat. Med. 5:340-343.
25. Heddini, A., F. Peterson, O. Kai, J. Shafi, J. Obiero, Q. Chen, A. Barragan, M. Wahlgren, and K. Marsh. 2001. Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors. Infect. Immun. 69:5849-5856.
26. Hoffman, S. L., and D. L. Doolan. 2000. Can malaria DNA vaccines on their own be as immunogenic and protective as prime-boost approaches to immunization? Dev. Biol. 104:121-132.
27. Jones, T. R., R. A. Gramzinski, J. C. Aguiar, B. K. Sim, D. L. Narum, S. R. Fuhrmann, S. Kumar, N. Obaldia, and S. L. Hoffman. 2002. Absence of antigenic competition in Aotus monkeys immunized with Plasmodium falciparum DNA vaccines delivered as a mixture. Vaccine 20:1675-1680.
28. Jones, T. R., D. L. Narum, A. S. Gozalo, J. Aguiar, S. R. Fuhrmann, H. Liang, J. D. Haynes, J. K. Moch, C. Lucas, T. Luu, A. J. Magill, S. L. Hoffman, and B. K. Sim. 2001. Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen. J. Infect. Dis. 183:303-312.
29. Lekana Douki, J. B., B. Traore, F. T. Costa, T. Fusai, B. Pouvelle, Y. Sterkers, A. Scherf, and J. Gysin. 2002. Sequestration of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A, a receptor for maternal malaria: monoclonal antibodies against the native parasite ligand reveal pan-reactive epitopes in placental isolates. Blood 100:1478-1483.
30. Miller, L. H., D. I. Baruch, K. Marsh, and O. K. Doumbo. 2002. The pathogenic basis of malaria. Nature 415:673-679.
31. Nagata, T., M. Uchijima, A. Yoshida, M. Kawashima, and Y. Koide. 1999. Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: analysis of plasmid DNA encoding a CTL epitope derived from microorganisms. Biochem. Biophys. Res. Commun. 261:445-451.
32. Narum, D. L., S. Kumar, W. O. Rogers, S. R. Fuhrmann, H. Liang, M. Oakley, A. Taye, B. K. Sim, and S. L. Hoffman. 2001. Codon optimization of gene fragments encoding Plasmodium falciparum merozoite proteins enhances DNA vaccine protein expression and immunogenicity in mice. Infect. Immun. 69:7250-7253.
33. Newbold, C. I. 1999. Antigenic variation in Plasmodium falcipanim: mechanisms and consequences. Curr. Opin. Microbiol. 2:420-425.
34. Newbold, C. I., R. Pinches, D. J. Roberts, and K. Marsh. 1992. Plasmodium falciparum: the human agglutinating antibody response to the infected red cell surface is predominantly variant specific. Exp. Parasitol. 75:281-292.
35. Ockenhouse, C. F., M. Ho, N. N. Tandon, G. A. Van Seventer, S. Shaw, N. J. White, G. A. Jamieson, J. D. Chulay, and H. K. Webster. 1991. Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1. J. Infect. Dis. 164:163-169.
36. Pain, A., D. J. Ferguson, O. Kai, B. C. Urban, B. Lowe, K. Marsh, and D. J. Roberts. 2001. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. Proc. Natl. Acad. Sci. USA 98:1805-1810.
37. Ricke, C. H., T. Staalsoe, K. Koram, B. D. Akanmori, E. M. Riley, T. G. Theander, and L. Hviid. 2000. Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A. J. Immunol. 165:3309-3316.
38. Rogers, W. O., J. K. Baird, A. Kumar, J. A. Tine, W. Weiss, J. C. Aguiar, K. Gowda, R. Gwadz, S. Kumar, M. Gold, and S. L. Hoffman. 2001. Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques. Infect. Immun. 69:5565-5572.
39. Rogers, W. O., W. R. Weiss, A. Kumar, J. C. Aguiar, J. A. Tine, R. Gwadz, J. G. Harre, K. Gowda, D. Rathore, S. Kumar, and S. L. Hoffman. 2002. Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen. Infect. Immun. 70:4329-4335.
40. Rowe, J. A., S. A. Kyes, S. J. Rogerson, H. A. Babiker, and A. Raza. 2002. Identification of a conserved Plasmodium falciparum var gene implicated in malaria in pregnancy. J. Infect. Dis. 185:1207-1211.
41. +-T-cell populations, Infect. Immun. 70:3493-3499.
42. Sedegah, M., W. Weiss, J. B. Sacci, Jr., Y. Charoenvit, R. Hedstrom, K. Gowda, V. F. Majam, J. Tine, S. Kumar, P. Hobart, and S. L. Hoffman. 2000. Improving protective immunity induced by DNA-based immunization: priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus. J. Immunol. 164:5905-5912.
43. Sim, B. K., D. L. Narum, H. Liang, S. R. Fuhrmann, N. Obaldia 3rd, R. Gramzinski, J. Aguiar, J. D. Haynes, J. K. Moch, and S. L. Hoffman. 2001. Induction of biologically active antibodies in mice, rabbits, and monkeys by Plasmodium falciparum EBA-175 region 11 DNA vaccine. Mol. Med. 7:247-254.
44. Staalsoe, T., R. Megnekou, N. Fievet, C. H. Ricke, H. D. Zornig, R. Leke, D. W. Taylor, P. Deloron, and L. Hviid. 2001. Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum-infected erythrocytes that protect against placental parasitemia. J. Infect. Dis. 184:618-626.
45. Urban, B. C., D. J. Ferguson, A. Pain, N. Willcox, M. Plebanski, J. M. Austyn, and D. J. Roberts. 1999. Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature 400:73-77.
46. Wang, L., J. G. Menting, C. G. Black, A. Stowers, D. C. Kaslow, S. L. Hoffman, and R. L. Coppel. 2000. Differences in epitope recognition, isotype and titer of antisera to Plasmodium falciparum merozoite surface protein 4 raised by different modes of DNA or protein immunization. Vaccine 19:816-824.
47. Yipp, B. G., D. I. Baruch, C. Brady, A. G. Murray, S. Looareesuwan, P. Kubes, and M. Ho. 2002. Recombinant PfEMP1 peptide inhibits and reverses cytoadherence of clinical Plasmodium falciparum isolates in vivo. Blood 101:331-337.
48. Zhang, L., E. Nolan, S. Kreitschitz, and D. P. Rabussay. 2002. Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation. Biochim. Biophys. Acta 1572:1-9.