Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation

Nature Biotechnology

Volumn 16, Issue 3, 1998, Pages 267-270

  Fukumoto, Takahiro ^a   Torigoe, Naohiko ^a   Kawabata, Shinichi ^a   Murakami, Masaaki ^a   Uede, Toshimitu ^b   Nishi, Tohru ^c   Ito, Yuji ^a   Sugimura, Kazuhisa ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Applied immunology; CD80; Phage display

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DNA SEQUENCE; FLOW CYTOMETRY; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION; BACTERIOPHAGES; CELL DIVISION; CRICETINAE; EPITOPES; IMMUNOCONJUGATES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MODELS, IMMUNOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDES; T-LYMPHOCYTES;

EID: 0031951990     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0398-267     Document Type: Article

References (25)

1. Bachan, D., Balas, M., Souroujon, M.C., Katchalski-Katzir, E., and Fuchs, S. 1995. Identification of epitopes within a highly immunigenic region of acetylcholine receptor by a phage epitope library. J. Immunol. 155:4264-4269.
2. 1 integrin from a phage display library. J. Cell Biol. 124:3733-3780.
3. Yayon, A., Aviezer, D., Safran, M., Gross, J.L., Heldman, Y., Cabilly, S. et al. 1993. Isolation of peptides thatinhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope library. Proc. Natl. Acad. Sci. USA 90:10643-10647.
4. Linsley, P.S. 1995. Distinct roles for CD28 and cytotoxio T lymphocyte-associated molecule-4 receptors during T cell activation. J.Exp. Med. 182:289-292.
5. Thompson, C.B. 1995. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation. Cell, 81:979-982.
6. Gribben, J.G., Freeman, G.J., Boussiotis, V.A., Rennert, P., Jellis, C.L., Greenfield, E. et al. 1995. CTLA4 mediates antigen-specific apoptosis of human T cells. Proc. Natl. Acad. Sci. USA 92:811-815.
7. Lenschow, D.J., Zeng, Y., Thistlethwaite, J.R., Montag, A., Brady, W. et al. 1992. Long-term survival of xenogeneic pancreatic oslet grafts induced by CTLA41g. Science 257:789-792.
8. Linsley, P.S., Wallace, P.M., Johnson, J., Gibson, M.G., Greene, J.L., Ledbetter, J.A. et al. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257:792-794.
9. Morton, P.A., Fu, X.T., Stewart, J.A., Giacoletto, K.S., White, S.L., Leysath, C.E. et al. 1996. Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2). J. Immunol. 156:1047-1054.
10. Walunas, T.L., Bakker, C.Y., and Bluestone, J.A. 1996. CTLA-4 ligation blocks. CD28-dependent T cell activation. J.Exp. Med. 183:2541-2550.
11. Krummel, M.F. and Allison, J.P. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459-465.
12. Parmley, S.F. and Smith, G.P. 1988. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene 33:305-318.
13. c-vc identified using a random 15-amino-acid peptide library. FEBS Lett. 399:237-240.
14. Wuttke, G.G., Keppner, J., and Rasched, I. 1989. Pore-forming properties of the adsorption protein of filamenteuse phage fd. Biochim. Biophys. Acta 985:239-247.
15. Smith, G.P. 1991. Surface presentation of protein epitopes using bacteriophage expression systems, Cutr. Opin. Biotech. 2:668-673.
16. Wrighton, N.C., Farrell, F.X., Chang, R., Kashyap, A.K., Barbone, F.P., Mulcahy, L.S. et al. 1996. Small peptides as potent mimetics of the protein hormone erythropoietin. Science 273:458-463.
17. Cwirla, S.E., Balasubramanian, P., Duffin, D.J., Wagstrom, C.R., Gates, C.M., Singer, S.C. et al. 1997. Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine. Science 276:1696-1699.
18. Welply, J.K., Steininger, C.N., Caparon, M., Michener, M.L., Howard, S.C., Pegg, L.E. et al. 1996. A peptide isolated by phage display binds to ICAM-1 and inhibits binding to LFA-1. Proteins 26:262-270.
19. Rennert, P., Furlong, K., Jellis, C., Greenfield, E., Freeman, G.J., Ueda, Y. et al. 1997. The IgV domain of human B7-2 (CD86) is sufficient to costimulate T lymphocytes and induce cytokine secretion. Int. Immunol. 9:805-813.
20. Waterhouse, P., Penninger, J.M., Timms, E., Wakeham, A., Shahinian, A., Lee, K.P. et al. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270:985-988.
21. Borriello, F., Sethna, M.P., Boyd, S.D., Schweitzer, A.N., Tivol, E.A., Jacoby, D. et al. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6:303-313.
22. Murakami, M., Takahashi, Y., Isashi, Y., Kon, S., Jia, W.Y., Inobe, M. et al. 1996. Identification and characterization of an alternative CTLA4 binding molecule (ACBM) on B cells. Proc. Natl. Acad. Sci. USA 93:7838-7842.
23. Mizushima, S. and Nagata, S. 1990. pEF-BOS, a powerful mammalian expression vector. Nucl. Acids Res. 18:5322.
24. Inobe, M., Linsley, P.S., Ledbetter, J.A., Nagai, Y., Tamakoshi, M. and Uede, T. 1994. Identification of an alternatively spliced form of the murine homologue of B7. Biochem. Biophys. Res. Com. 200:443-449.
25. Hashiguchi, S., Hino, S., Taniguchi, Y., Kurimoto, M., Fukuda, K., Ohyama, M. et al. 1996. Immunodominance of seven regions of a major allergen, Cry j 2, of Japanese cedar pollen for T-cell immunity. Allergy 51:621-632.