Recombinant PfEMP1 peptide inhibits and reverses cytoadherence of clinical Plasmodium falciparum isolates in vivo

Blood

Volumn 101, Issue 1, 2003, Pages 331-337

  Yipp, Bryan G ^a,b,c,d   Baruch, Dror I ^a,b,c,d   Brady, Ciaran ^a,b,c,d   Murray, Allan G ^a,b,c,d   Looareesuwan, Sornchai ^a,b,c,d   Kubes, Paul ^a,b,c,d   Ho, May ^a,b,c,d,e  

^a UNIVERSITY OF CALGARY   (Canada)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

^d MAHIDOL UNIVERSITY   (Thailand)

^e Department of Microbiology ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; CELL RECEPTOR; ERYTHROCYTE MEMBRANE PROTEIN 1; INTERCELLULAR ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 84H10; PROTEIN PPMC 179; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL STIMULATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; MICROVASCULATURE; MOUSE; NONHUMAN; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING; SCID MOUSE; SKIN GRAFT;

EID: 0037220131     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-06-1725     Document Type: Article

References (37)

1. White NJ, Ho M. The pathophysiology of malaria. Adv Parasitol. 1992;31:83-173.
2. MacPherson GG, Warrell MJ, White NJ, Looareesuwan S, Warrell DA. Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am J Pathol. 1985;119:385-401.
3. Udomsangpetch R, Reinhardt PH, Schollaardt T, Elliott JF, Kubes P, Ho M. Promiscuity of clinical Plasmodium falciparum isolates for multiple adhesion molecules under flow conditions. J Immunol. 1997;158:4358-4364.
4. Ho M, Schollaardt T, Niu X, Looareesuwan S, Patel KD, Kubes P. Characterization of Plasmodium falciparum-infected erythrocyte and P-selectin interaction under flow conditions. Blood. 1998;91:4803-4809.
5. Yipp BG, Anand S, Schollaardt T, Patel KD, Looareesuwan S, Ho M. Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelial cells under flow. Blood. 2000;96:2292-2298.
6. Ho M, Hickey MJ, Murray AG, Andonegui G, Kubes P. Visualization of Plasmodium falciparum-endothelium interactions in human microvasculature: Mimicry of leukocyte recruitment. J Exp Med. 2000;192:1205-1211.
7. Baruch DI, Ma XC, Pasloske B, Howard RJ, Miller LH. CD36 peptides that block cytoadherence define the CD36 binding region for Plasmodium falciparum-infected erythrocytes. Blood. 1999;94:2121-2127.
8. Navazo MD, Daviet L, Savill J, Ren Y, Leung LL, McGregor JL. Identification of a domain (155-183) on CD36 implicated in the phagocytosis of apoptotic neutrophils. J Biol Chem. 1996;271:15381-15385.
9. Magowan C, Wollish W, Anderson L, Leech J. Cytoadherence by Plasmodium falciparum-infected erythrocytes is correlated with the expression of a family of variable proteins on infected erythrocytes. J Exp Med. 1988;168:1307-1320.
10. Baruch DI, Pasloske BL, Singh HB, et al. Cloning the P falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell. 1995;82:77-87.
11. Su XZ, Heatwole VM, Wertheimer SP, et al. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell. 1995;82:89-100.
12. Scherf A, Hernandez-Rivas R, Buffet P, et al. Antigenic variation in malaria: In situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. EMBO J. 1998;17:5418-5426.
13. Baruch DI, Gormely JA, Ma C, Howard RJ, Pasloske BL. Plasmodium falciparum erythrocyte membrane protein 1 is a parasitized erythrocyte receptor for adherence to Cd36, thrombospondin, and intercellular adhesion molecule 1. Proc Natl Acad Sci U S A. 1996;93:3497-3502.
14. Smith JD, Gamain B, Baruch DI, Kyes S. Decoding the language of var genes and Plasmodium falciparum sequestration. Trends Parasitol. 2001;17:538-545.
15. Baruch DI, Ma XC, Singh HB, Bi X, Pasloske BL, Howard RJ. Identification of a region of PfEMP1 that mediates adherence of Plasmodium falciparum infected erythrocytes to CD36: Conserved function with variant sequence. Blood. 1997;90:3766-3775.
16. Cooke BM, Nicoll CL, Baruch DI, Coppel RL. A recombinant peptide based on PfEMP-1 blocks and reverses adhesion of malaria-infected red blood cells to CD36 under flow. Mol Microbiol. 1998;30:83-90.
17. Gamain B, Miller LH, Baruch DI. The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes. Proc Natl Acad Sci U S A. 2001;98:2664-2669.
18. Baruch DI, Gamain B, Barnwell JW, et al. Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line. Proc Natl Acad Sci U S A. 2002;99:3860-3865.
19. World Health Organization. Severe falciparum malaria. Tran R Soc Trop Med Hyg. 2000;94(suppl 1):S1-S90.
20. Udomsangpetch R, Taylor BJ, Looareesuwan S, White NJ, Elliott JF, Ho M. Receptor specificity of clinical Plasmodium falciparum isolates: Nonadherence to cell-bound E-selectin and vascular cell adhesion molecule-1. Blood. 1996;88:2754-2760.
21. Petzelbauer P, Bender JR, Wilson J, Pober JS. Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. J Immunol. 1993;151:5062-5072.
22. McCormick CJ, Craig A, Roberts D, Newbold CI, Berendt AR. Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human dermal microvascular endothelium. J Clin Invest. 1997;100:2521-2529.
23. Murray AG, Petzelbauer P, Hughes CC, Costa J, Askenase P, Pober JS. Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse. Proc Natl Acad Sci U S A. 1994;91:9146-9150.
24. Forlow SB, White EJ, Barlow SC, et al. Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice. J Clin Invest. 2000;106:1457-1466.
25. Gamain B, Smith JD, Miller LH, Baruch DI. Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36. Blood. 2001;97:3268-3274.
26. Day NP, Hien TT, Schollaardt T, et al. The prognostic and pathophysiological role of pro- and anti-inflammatory cytokines in severe malaria. J Infect Dis. 1999;180:1288-1297.
27. Looareesuwan S, Sjostrom L, Krudsood S, et al. Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria. Am J Trop Med Hyg. 1999;61:26-33.
28. van Hensbroek MB, Palmer A, Onyiorah E, et al. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria. J Infect Dis. 1996;174:1091-1097.
29. Looareesuwan S, Wilairatana P, Vannaphan S, et al. Pentoxifylline as an ancillary treatment for severe falciparum malaria in Thailand. Am J Trop Med Hyg. 1998;58:348-353.
30. Riddle MS, Jackson JL, Sanders JW, Blazes DL. Exchange transfusion as an adjunct therapy in severe Plasmodium falciparum malaria: A metaanalysis. Clin Infect Dis. 2002;34:1192-1198.
31. Jorgensen C, Couret I, Canovas F, et al. In vivo migration of tonsil lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: Involvement of LFA-1. Autoimmunity. 1996;24:179-185.
32. Casasnovas JM, Springer TA. Pathway of rhinovirus disruption by soluble intercellular adhesion molecule 1 (ICAM-1): An intermediate in which ICAM-1 is bound and RNA is released. J Virol. 1994;68:5882-5889.
33. David PH, Hommel M, Miller LH, Udeinya IJ, Oligino LD. Parasite sequestration in Plasmodium falciparum malaria: Spleen and antibody modulation of cytoadherence of infected erythrocytes. Proc Natl Acad Sci U S A. 1983;80:5075-5079.
34. Diggs CL, Hines F, Wellde BT. Plasmodium falciparum: Passive immunization of Aotus lemurinus griseimembra with immune serum. Exp Parasitol. 1995;80:291-296.
35. Pouvelle B, Meyer P, Robert C, Bardel L, Gysin J. Chondroitin-4-sulfate impairs in vitro and in vivo cytoadherence of Plasmodium falciparum infected erythrocytes. Mol Med. 1997;3:508-518.
36. Gamain B, Smith JD, Miller LH, Baruch DI. Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36. Blood. 2001;97:3268-3274.
37. Turner GD, Morrison H, Jones M, et al. An immunohistochemical study of the pathology of fatal malaria: Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am J Pathol. 1994;145:1057-1069.