A new proliferation marker, minichromosome maintenance protein 2, is associated with tumor aggressiveness in esophageal squamous cell carcinoma

Journal of Surgical Oncology

Volumn 84, Issue 1, 2003, Pages 24-30

  Kato, Hiroyuki ^a   Miyazaki, Tatsuya ^a   Fukai, Yasuyuki ^a   Nakajima, Masanobu ^a   Sohda, Makoto ^a   Takita, Junko ^a   Masuda, Norihiro ^a   Fukuchi, Minoru ^a   Manda, Ryokuhei ^a   Ojima, Hitoshi ^a   Tsukada, Katsuhiko ^a   Asao, Takayuki ^a   Kuwano, Hiroyuki ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Esophageal carcinoma; Immunohistochemistry; Ki 67; Minichromosome maintenance protein 2 (MCM2); Prognostic value; Tumor aggressiveness

Indexed keywords

KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN; MINICHROMOSOME MAINTENANCE PROTEIN 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER SURGERY; CELL PROLIFERATION; DISEASE MARKER; ESOPHAGUS CARCINOMA; ESOPHAGUS SURGERY; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR CELL;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0042191801     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/jso.10287     Document Type: Article

References (28)

1. Tanaka T, Knapp D, Nasmyth K: Loading of an Mcm protein c onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 1997;90:649-660.
2. Kearsey SE, Labib K: MCM proteins: Evolution, properties, and role in DNA replication. Biochim Biophys Acta 1998;1398:113-136.
3. Tye BK: MCM proteins in DNA replication. Annu Rev Biochem 1999;68:649-686.
4. Dutta A, Bell SP: Initiation of DNA replication in eukaryotic cells. Annu Rev Cell Dev Biol 1997;13:293-332.
5. Labib K, Tercero JA, Diffley JF: Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 2000;288: 1643-1647.
6. Labib K, Kearsey SE, Diffley JF: MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol Biol Cell 2001;12:3658-3667.
7. Lei M, Tye BK: Initiating DNA synthesis: From recruiting to activating the MCM complex. J Cell Sci 2001;114:1447-1454.
8. Stoeber K, Mills AD, Kubota Y, et al.: Cdc6 protein causes premature entry into S phase in a mammalian cell-free system. EMBO J 1998;17:7219-7229.
9. Williams RS, Shohet RV, Stillman B: A human protein related to yeast Cdc6p. Proc Natl Acad Sci USA 1997;94:142-147.
10. Yan Z, DeGregori J, Shohet R, et al.: Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci USA 1998;95:3603-3608.
11. Stoeber K, Tlsty TD, Happerfield L, et al.: DNA replication licensing and human cell proliferation. J Cell Sci 2001;114:2027-2041.
12. Stoeber K, Halsall I, Freeman A, et al.: Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine. Lancet 1999;354:1524-1525.
13. Williams GH, Romanowski P, Morris L, et al.: Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. Proc Natl Acad Sci USA 1998;95:14932-14937.
14. Freeman A, Morris LS, Mills AD, et al.: Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res 1999;5:2121-2132.
15. Going JJ, Keith WN, Neilson L, et al.: Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa. Gut 2002;50:373-377.
16. Meng MV, Grossfeld GD, Williams GH, et al.: Minichromosome maintenance protein 2 expression in prostate: Characterization and association with outcome after therapy for cancer. Clin Cancer Res 2001;7:2712-2718.
17. Todorov IT, Werness BA, Wang HQ, et al.: HsMCM2/BM28: A novel proliferation marker for human tumors and normal tissues. Lab Invest 1998;78:73-78.
18. Tan DF, Huberman JA, Hyland A, et al.: MCM2 - a promising marker for premalignant lesions of the lung: A cohort study. BMC Cancer 2001;1:6-12.
19. Ramnath N, Hernandez FJ, Tan DF, et al.: MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer. J Clin Oncol 2001;19:4259-4266.
20. Rodins K, Cheale M, Coleman N, et al.: Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: Relationship to tumor dormancy and potential clinical utility. Clin Cancer Res 2002;8:1075-1081.
21. Wharton SB, Chan KK, Anderson JR, et al.: Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade, and prognosis. Neuropathol Appl Neurobiol 2001;27:305-313.
22. Kodani I, Shomori K, Osaki M, et al.: Expression of minichromosome maintenance 2 (MCM2), Ki-67, and cell-cycle-related molecules, and apoptosis in the normal - dysplasia-carcinoma sequence of the oral mucosa. Pathobiology 2001;69:150-158.
23. Ikeda G, Isaji S, Chandra B, et al.: Prognostic significance of biologic factors in squamous cell carcinoma of the esophagus. Cancer 1999;86:1396-1405.
24. Youssef EM, Matsuda T, Takada N, et al.: Prognostic significance of the MIB-1 proliferation index for patients with squamous cell carcinoma of the esophagus. Cancer 1995;76:358-366.
25. Endl E, Gerdes J: The Ki-67 protein: Fascinating forms and an unknown function. Exp Cell Res 2000;257:231-237.
26. Schluter C, Duchrow M, Wohlenberg C, et al.: The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 1993;123:513-522.
27. Maeshima Y, Kashihara N, Sugiyama H, et al.: Antisense oligonucleotides to proliferating cell nuclear antigen and Ki-67 inhibit human mesangial cell proliferation. J Am Soc Nephrol 1996;7:2219-2229.
28. Davies RJ, Freeman A, Morris LS, et al.: Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool. Lancet 2002;359:1917-1919.