Expression of minichromosome maintenance 2 (MCM2), Ki-67, and cell-cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa

Pathobiology

Volumn 69, Issue 3, 2001, Pages 150-158

  Kodani, Isamu ^a   Shomori, Kohei ^a   Osaki, Mitsuhiko ^a   Kuratate, Itaru ^a   Ryoke, Kazuo ^a   Ito, Hisao ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Ki 67; Minichromosome maintenance 2; Oral dysplasia; P21; P27; P53; Squamous cell carcinoma

Indexed keywords

BIOLOGICAL MARKER; MINICHROMOSOME MAINTENANCE PROTEIN; MINICHROMOSOME MAINTENANCE PROTEIN 2; PROTEIN P21; PROTEIN P27; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EPITHELIUM DYSPLASIA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MOUTH MUCOSA; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MOUTH NEOPLASMS; NUCLEAR PROTEINS; PRECANCEROUS CONDITIONS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0035725857     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048770     Document Type: Article

References (48)

1. Variant subline with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas
2. Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes
3. Altered expression of transforming growth factor-β1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix
4. Cervix dysplasias: Study of Rb and p53 gene expression and correlation with mitotic activity
5. Cyclin dependent kinase inhibitor p27Kip1 expression in normal and neoplastic cervical epithelium
6. Proliferation in the normal cervix and in preinvasive cervical lesions
7. Oral leukoplakia and malignant transformation: A follow-up study of 257 patients
8. Longitudinal studies in oral leukoplakias
9. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma
10. Occurrence of epithelial dysplasia in oral leukoplakia: Analysis and follow-up study of 12 cases
11. Purification of an MCM-containing complex as a component of the DNA replication licensing system
12. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor
13. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells
14. The MCM2-3-5 proteins: Are they replication licensing factors?
15. Definition of leukoplakia and related lesions: An aid to studies on oral precancer
16. Establishment of human squamous carcinoma cell lines highly and minimally sensitive to bleomycin and analysis of factors involved in the sensitivity
17. Apoptosis in human gastric mucosa, chronic gastritis, dysplasia and carcinoma: Analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling
18. Apoptosis in normal epithelium, pre-malignant and malignant lesions of the oropharynx and oral cavity: A preliminary study
19. Apoptotic activity is increased in parallel with the metaplasia-dysplasia-carcinoma sequence of the bronchial epithelium
20. p53 status and the efficacy of cancer therapy in vivo
21. Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations
22. Apoptosis in operated small cell lung carcinoma is inversely related to tumor necrosis and p53 immunoreactivity
23. p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas
24. K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis
25. Alterations of p16/CDKN2, p53 and ras genes in oral squamous cell carcinomas and premalignant lesions
26. Detection of a rare point mutation at codon 59 and relatively high incidence of H-ras mutation in Indian oral cancer
27. Mutations in the p53 gene occur in diverse human tumour types
28. The p53 tumor suppressor gene
29. Wild-type p53 is a cell cycle checkpoint determinant following irradiation
30. Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
31. p53 and E2F-1 cooperate to mediate apoptosis
32. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1
33. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
34. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
35. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
36. Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7
37. p21 is necessary for the p53-mediated G1 arrest in human cancer cells
38. HsMCM2/BM28: A novel proliferation marker for human tumors and normal tissues
39. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication
40. Mini-chromosome maintenance proteins as biological markers of dysplasia and malignancy
41. The effect of tissue fixation on immunostaining for proliferating cell nuclear antigen with the monoclonal antibody PC10
42. Monoclonal antibody Ki-67: Its use in histopathology
43. Ki-67 detects a nuclear matrix associated proliferation-related antigen: I. Intracellular localization during interphase
44. Ki-67 detects a nuclear matrix-associated proliferation-related antigen: II. Localization in mitotic cells and association with chromosomes
45. Simultaneous staining of exponentially growing versus plateau phase cells with the proliferation-associated antibody Ki-67 and propidium iodide: Analysis by flow cytometry
46. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
47. A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell divsion
48. Expression of the nuclear protein mitotin in differentiating in vitro HL 60 cells