Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro

Toxicological Sciences

Volumn 74, Issue 2, 2003, Pages 260-270

  Thompson, Karol L ^a   Sistare, Frank D ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

globin; c fos; gadd153; HepG2; K562; Tg.AC

Indexed keywords

AMILORIDE; CARCINOGEN; DIPYRIDAMOLE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN P53; PYRIMETHAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CARCINOGEN TESTING; CELL STRAIN HEPG2; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG SCREENING; DRUG SOLUBILITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE RAS; PROMOTER REGION; SENSITIVITY AND SPECIFICITY; TUMOR SUPPRESSOR GENE;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, FOS; GENES, REPORTER; GENETIC MARKERS; GLOBINS; GREEN FLUORESCENT PROTEINS; HUMANS; LUCIFERASES; LUMINESCENT PROTEINS; MICE; MICE, TRANSGENIC; MODELS, GENETIC; PHARMACEUTICAL PREPARATIONS; PROMOTER REGIONS (GENETICS); SENSITIVITY AND SPECIFICITY; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; TRANSGENES;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0042090467     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg113     Document Type: Article

References (38)

1. Angel, P., Szabowski, A., and Schorpp-Kistner, M. (2001). Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene 20, 2413-2423.
2. Asoh, K-I., Saburi, Y., Sato, I., Nogae, I., Kohno, K., and Kuwano, M. (1989). Potentiation of some anticancer agents by dipyridamole against drug-sensitive and drug-resistant cancer cell lines. Jpn. J. Cancer Res. 80, 475-481.
3. Cannon, R. E., Spalding, J. W., Virgil, K. M., Faircloth, R. S., Humble, M. C., Lacks, G. D., and Tennant, R. W. (1998). Induction of transgene expression in Tg.AC (v-Ha-ras) transgenic mice concomitant with DNA hypomethylation. Mol. Carcinog. 21, 244-250.
4. Compere, S. J., Baldacci, P., and Jaenisch, R. (1988). Oncogenes in transgenic mice. Biochim. Biophys. Acta 948, 129-149.
5. Contrera, J. F., Jacobs, A. C., and DeGeorge, J. J. (1997). Carcinogenicity testing and the evaluation of regulatory requirements for pharmaceuticals. Regul. Toxicol. Pharmacol. 25, 130-145.
6. Curtin, N. J., and Turner, D. P. (1999). Dipyridamole-mediated reversal of multidrug resistance in MRP over-expressing human lung carcinoma cells in vitro. Eur. J. Cancer 35, 1020-1026.
7. Egeli, U. (1998). Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures. Teratog. Carcinog. Mutagen 18, 163-169.
8. Egeli, U., and Erdogen, G. (1991). The clastogenic effect of pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures. Cell Biol. Toxicol. 7, 347-356.
9. Elsliger, M-A., Wachter, R. M., Hanson, G. T., Kallio, K., and Remington, S. J. (1999). Structural and spectral response of green fluorescent protein variants to changes in pH. Biochemistry 38, 5296-5301.
10. Garcia-Canero, R., Trilla, C., Perez de Diego, J., Diaz-Gil, J. J., and Cobo, J. M. (1999). Na +: H+ exchange inhibition induces intracellular acidosis and differentially impairs cell growth and viability of human and hepatocarcinoma cells. Toxicol. Lett. 106, 215-228.
11. Greenhalgh, D. A., Quintanilla, M. I., Orengo, C. C., Barber, J. L., Eckhardt, J. N., Rothnagel, J. A., and Roop, D. R. (1993). Cooperation between v-fos and v-rasHA induces autonomous papillomas in transgenic epidermis but not malignant conversion. Cancer Res. 53, 5071-5075.
12. Guyton, K. Z., Xu, Q., and Holbrook, N. J. (1996). Induction of the mammalian stress response gene GADD153 by oxidative stress: Role of AP-1 element. Biochem. J. 314, 547-554.
13. Hansen, L. A., and Tennant, R. W. (1994). Follicular origin of epidermal papillomas in v-Ha-ras-transgenic TG.AC mouse skin. Proc. Natl. Acad. Sci. U.S.A. 91, 7822-7826.
14. Honchel, R., Rosenzweig, B. A., Thompson, K. L., Blanchard, K. T., Furst, S. M., Stoll, R. E., and Sistare, F. D. (2001). Loss of palindromic symmetry in Tg.AC mice with a nonresponder phenotype. Mol. Carcinog. 30, 99 -110.
15. Leder, A., Kuo, A., Cardiff, R. D., Sinn, E., and Leder, P. (1990). v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid. Proc. Natl. Acad. Sci. U.S.A. 87, 9178-9182.
16. Lin, X., Gately, D. P., Hom, D., Mishima, M., Los, G., and Howell, S. B. (2001). Quantification of tumor cell injury in vitro and in vivo using expression of green fluorescent protein under the control of the GADD153 promoter. Int. J. Cancer 91, 555-562.
17. Luethy, J. D., and Holbrook, N. J. (1992). Activation of the GADD153 promoter by genotoxic agents: A rapid and specific response to DNA damage. Cancer Res. 52, 5-10.
18. Martelli, A., Mattioli, F., Ghia, M., Mereto, E., and Brambilla, G. (1996). Comparative study of DNA repair induced by cyproterone acetate, chlormadinone acetate and megestrol acetate in primary cultures of human and rat hepatocyes. Carcinogenesis 17, 1153-1156.
19. McEvoy, G. K., Ed. (1998). American Hospital Formulary Service Drug Information, American Society of Health-System Pharmacists, Bethesda, MD.
20. Morrow, C. S., Smitherman, P. K., and Townsend, A. J. (2000). Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells. Mol. Carcinog. 29, 170-178.
21. National Toxicology Program. (1978). Bioassay of pyrimethamine for possible carcinogenicity (CAS No. 58-14-0). Technical Report Series No. 77, U.S. Department of Health and Human Services, Public Health Service, Bethesda, MD.
22. Ono, T., Sekiya, T., Takahashi, Y., Sasaki, Y. F., and Ohta, T. (1997). Species-specificity of pyrimethamine in the rodent bone marrow micronucleus test. Mutat. Res. 390, 167-170.
23. Physicians' Desk Reference Electronic Library (2002). Medical Economics Company, Montvale, NJ.
24. Price, B. D., and Calderwood, S. K. (1992). Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Cancer Res. 52, 3814-3817.
25. Robinson, D., and MacDonald, J. S. (2001). Background and framework for ILSI's collaborative evaluation program on alternative models for carcinogenicity assessment. Toxicol. Pathol. 29, 13-19.
26. Sistare, F. D., Thompson, K. L., Honchel, R., and DeGeorge, J. (2002). Evaluation of the Tg.AC transgenic mouse assay for testing the human carcinogenic potential of pharmaceuticals-practical pointers, mechanistic clues, and new questions. Int. J. Toxicol. 21, 65-79.
27. Spalding, J. W., French, J. E., Tice, R. R., Furedi-Machacek, M., Haseman, J. K., and Tennant, R. W. (1999). Development of a transgenic mouse model for carcinogenesis bioassays: Evaluation of chemically induced skin tumors in Tg.AC mice. Toxicol. Sci. 49, 241-254.
28. + exchange activity. Hepatology 22, 588-597.
29. Thompson, K. L., Rosenzweig, B. A., and Sistare, F. D. (1998). An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness. Toxicol. Pathol. 26, 548-555.
30. Thompson, K. L., Rosenzweig, B. A., Tsong, Y., and Sistare, F. D. (2000). Evaluation of in vitro reporter gene induction assays for use in a rapid prescreen for compound selection to test specificity in the Tg.AC mouse short-term carcinogenicity assay. Toxicol. Sci. 57, 43-53.
31. Todd, M. D., Lee, M. J., Williams, J. L., Nalezny, J. M., Gee, P., Benjamin, M. B., and Farr, S. B. (1995). The CAT-Tox (L) Assay: A sensitive and specific measure of stress-induced transcription in transformed human liver cells. Fundam. Appl. Toxicol. 28, 118-128.
32. Trempus, C. S., Ward, S., Farris, G., Malarkey, D., Faircloth, R. S., Cannon, R. E., and Mahler, J. F. (1998). Association of v-Ha-ras transgene expression with development of erythroleukemia in Tg.AC transgenic mice. Am. J. Pathol. 153, 247-254.
33. + antiport inhibitors. J. Biol. Chem. 267, 19043-19046.
34. Van Hummeln, P., Elhajouji, A., and Kirsch-Volders, M. (1995). Clastogenic and aneugenic effects of three benzimidazole derivatives in the in vitro micronucleus test using human lymphocytes. Mutagenesis 10, 23-29.
35. Versantwoort, C. H. M., Broxterman, H. J., Bagrij, T., Scheper, R. J., and Twentyman, P. R. (1995). Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br. J. Cancer 72, 82-89.
36. Vijayalaxmi, K. K., and Vishalakshi, M. (2000). Evaluation of the genotoxic effects of pyrimethamine, an antimalarial drug, in the in vivo mouse. Teratog. Carcinog. Mutagen. 20, 65-71.
37. Wang, X-Z., Lawson, B., Brewer, J., Zinzser, H., Sanjay, A., Boorstein, R., Kreibich, G., Hendershot, L., and Ron, D. (1996). Signals from the stressed endoplasmic reticulum induce C/EBP homologous protein (CHOP/GADD153). Mol. Cell. Biol. 16,4273-4280.
38. Werner S., Kunz, S., Beckurts, T., Heidecke, C.-D., Wolff, T., and Schwarz, L. R. (1997) Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes. Mutat. Res. 395, 179-187.