Comparative study of DNA repair induced by cyproterone acetate, chlormadinone acetate and megestrol acetate in primary cultures of human and rat hepatocytes

Carcinogenesis

Volumn 17, Issue 5, 1996, Pages 1153-1156

  Martelli, Antonietta ^a   Mattioli, Francesca ^a   Ghia, Marco ^a   Mereto, Eugenio ^a   Brambilla, Giovanni ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORMADINONE ACETATE; CYPROTERONE ACETATE; DNA; GESTAGEN; MEGESTROL ACETATE;

ADULT; AGED; ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DNA REPAIR; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; LIVER CELL CULTURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

ANIMALS; CELLS, CULTURED; CHLORMADINONE ACETATE; CYPROTERONE ACETATE; DNA REPAIR; FEMALE; HUMANS; LIVER; MALE; MEGESTROL; MEGESTROL ACETATE; PROGESTERONE CONGENERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029974407     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.5.1153     Document Type: Article

References (11)

1. Topinka,J., Andrae,U., Schwarz,L.R. and Wolff,T. (1993) Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures. Carcinogenesis, 14, 423-427.
2. Neumann,I., Thierau,D., Andrae,U., Greim,H. and Schwarz,L.R. (1992) Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in γ-glutamyltranspeptidase-positive cells. Carcinogenesis. 13, 373-378.
3. Martelli,A., Mattioli,F., Fazio,S., Andrae,U. and Brambilla,G. (1995) DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate. Carcinogenesis, 16, 1265-1269.
4. Deml,E., Schwarz,L.R. and Oesterle,D. (1993) Initiation of enzyme-altered foci by the synthetic steroid cyproterone acetate in rat liver foci bioassay. Carcinogenesis, 14, 1229-1231.
5. Watanabe,S., Yamasaky,S., Tanae,A., Ibi,I. and Honna,T. (1994) Three cases of hepatocellular carcinoma among cyproterone users. Lancet, 344, 1567-1568.
6. Rüdiger,T., Beckmann,J. and Queisser,W. (1995) Hepatocelluar carcinoma after treatment with cyproterone acetate combined with ethinyloestradiol. Lancet. 345, 452-453.
7. Topinka,J., Binkova,B., Zhu,H.K., Andrae,U., Neumann,I., Schwarz,L.R., Wemer,S. and Wolff,T. (1995) DNA damaging activity of the cyproterone acetate analogues chlormadinone acetate and megestrol acetate in rat liver. Carcinogenesis, 16, 1483-1487.
8. Williams,G.M. (1977) The detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures. Cancer Res., 37, 1845-1851.
9. Madle,S. et al. (1994) Recommendations for the performance of UDS tests in vitro and in vivo. Mutat. Res., 312, 263-285.
10. Martelli,A., Brambilla Campart,G., Ghia,M., Allavena,A., Mereto,E. and Brambilla,G. (1996) Induction of micronuclei and initiation of enzymealtered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate or megestrol acetate. Carcinogenesis, 17, in press.
11. Kerdar,R.S., Baumann,A., Brudny-Klöppel,M., Biere,H., Blode,H. and Kuhnz,W. (1995) Identification of 3α-hydroxy-cyproterone acetate as a metabolite of cyproterone acetate in the bile of female rats and the potential of this and other already known or putative metabolites to form DNA adducts in vitro. Carcinogenesis, 16, 1835-1841.