Delineation of signalling pathway leading to antioxidant-dependent inhibition of dexamethasone-mediated muscle cell death

Journal of Muscle Research and Cell Motility

Volumn 24, Issue 1, 2003, Pages 33-53

  Orzechowski, Arkadiusz ^a   Jank, Michał ^a   Gajkowska, Barbara ^b   Sadkowski, Tomasz ^a   Godlewski, Michał Marek ^a   Ostaszewski, Piotr ^a  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^b POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 7 AMINODACTINOMYCIN; ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; CALCIMYCIN; CALCIUM ION; CALPAIN; CALPASTATIN; CREATINE KINASE; CYCLIC AMP; DACTINOMYCIN; DEXAMETHASONE; DNA FRAGMENT; GENOMIC DNA; GLUCOCORTICOID; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PROTEIN KINASE C;

ANIMAL CELL; CELL DEATH; CELL ULTRASTRUCTURE; CELL VIABILITY; CONFERENCE PAPER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOMETRY; DNA CONTENT; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; GENOME; MITOCHONDRIAL RESPIRATION; MUSCLE CELL; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CALCIUM SIGNALING; CALPAIN; CASPASE 3; CASPASES; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CHROMONES; CYCLIC AMP; DACTINOMYCIN; DEXAMETHASONE; DNA; GLYCOPROTEINS; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MICROSCOPY, PHASE-CONTRAST; MORPHOLINES; MUSCLE CELLS; MUSCLE DEVELOPMENT; MUSCLE FIBERS; PHOSPHOLIPASES A; PROTEIN BIOSYNTHESIS; PROTEIN KINASE C; PROTEINS; RATS; SIGNAL TRANSDUCTION;

ANIMALIA; FELIS CATUS;

EID: 0041928098     PISSN: 01424319     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024887431768     Document Type: Conference Paper

References (75)

1. Alderton JM and Steinhardt RA (2000) Calcium influx through calcium leak channels is responsible for the elevated levels of calcium-dependent proteolysis in dystrophic myotubes. J Biol Chem 275: 9452-9460.
2. Anderson JE, Weber M and Vargas C (2000) Deflazacort increases laminin expression and myogenic repair, and induces early persistent functional gain in mdx mouse muscular dystrophy. Cell Transplant 9: 551-564.
3. Arnold TE, Worrell RA, Barth JL, Morris J and Ivarie R (1994) Dexamethasone-mediated induction of mMTV-myf5 in DD3 myoblasts increases endogenous myogenin expression but does not transactivate myf5. Exp Cell Res 212: 321-328.
4. Baker AF, Briehl MM, Dorr R and Powis P (1996) Decreased antioxidant defence and increased oxidant stress during dexamethasone-induced apoptosis: bcl-2 prevents the loss of antioxidant enzyme activity. Cell Death Diff 3: 207-213.
5. Balcerzak D, Cottin P, Poussard S, Cucuron A, Brustis JJ and Ducastaing A (1998) Calpastatin-modulation of m-calpain activity is required for myoblast fusion. Eur J Cell Biol 75: 247-253.
6. Ball EH and Sanwall BD (1980) A synergistic effect of glucocorticoids and insulin on the differentiation of myoblasts. J Cell Physiol 102: 27-36.
7. Barnoy S, Glaser T and Kosower NS (1997) Calpain and calpastatin in myoblast differentiation and fusion: effects of inhibitors. Biochem Biophys Acta 1358: 181-188.
8. Barnoy S, Glaser T and Kosower NS (1998) The calpain-calpastatin system and protein degradation in fusing myoblasts. Biochem Biophys Acta 1402: 52-60.
9. 2+-dependent thiol protease) with its endogenous inhibitor calpastatin in myoblasts. J Cell Biochem 74: 522-531.
10. Bechet DM, Ferrara MJ, Mordier SB, Roux MP, Deval CD and Obled A (1991) Expression of lysosomal cathepsin B during calf myoblast-myotube differentiation. J Biol Chem 266: 14,104-14,112.
11. Behl C (1998) Effects of glucocorticoids on oxidative stress-induced hippocampal cell death: implications for the pathogenesis of Alzheimer's disease. Exp Gerontol 33: 689-696.
12. Bigio MRD (2000) Calcium-mediated proteolytic damage in white matter of hypothalamic rats? J Neuropathol Exp Neurol 59: 946-954.
13. 2 in uterine stromal cells. Biochem Biophys Res Commun 276: 613-618.
14. Briehl MM and Baker AF (1996) Modulation of the antioxidant defence as a factor in apoptosis. Cell Death Diff 3: 63-70.
15. Briehl MM, Baker AF, Siemankowski LM and Morreale J (1997) Modulation of antioxidant defences during apoptosis. Oncology Res 9: 281-285.
16. Briehl MM, Cotgrave IA and Powis P (1995) Downregulation of the antioxidant defence during glucocorticoid-mediated apoptosis. Cell Death Diff 2: 41-46.
17. Brustis J-J, Elamrani N, Balcerzak D, Safwate A, Soriano M, Poussard S, Cottin P and Ducastaing A (1994) Rat myoblast fusion requires exteriorised m-calpain activity. Eur J Cell Biol 64: 320-327.
18. Chua BT, Guo K and Li P (2000) Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases. J Biol Chem 275: 5131-5135.
19. Dourdin N, Balcerzak D, Brustis JJ, Poussard S, Cottin P and Ducastaing A (1999) Potential m-calpain substrates during myoblast fusion. Exp Cell Res 246: 433-442.
20. Du J, Mitch E, Wang X and Price SR (2000) Glucocorticoids induce proteasome C3 subunit expression in L6 muscle cells by opposing the suppression of its transcription by NF-κB. J Biol Chem 275: 196,661-19,666.
21. Ewart HS, Somwar R and Klip A (1998) Dexamethasone stimulates the expression of GLUT1 and GLUT4 proteins via different signalling pathways in L6 skeletal muscle cells. FEBS Lett 425: 179-183.
22. Fischer D, Sun X, Gang G, Pritts T and Hasselgren P-O (2000) The gene expression of ubiquitin ligase E3α is upregulated in skeletal muscle during sepsis in rats - potential role of glucocorticoids. Biochem Biophys Res Commun 267: 504-508.
23. Friday BB, Horsley V and Pavlath GK (2000) Calcineurin activity is required for the initiation of skeletal muscle differentiation. J Cell Biol 149: 657-665.
24. Gao G and Dou QP (2000) N-terminal cleavage of Bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes Bcl-2-independent cytochrome C release and apoptotic cell death. J Cell Biochem 80: 53-70.
25. Gardner AM, Xu F-H, Fady C, Jacoby FJ, Duffey DC, Tu Y and Lichtenstein A (1997) Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide. Free Rad Biol Med 22: 73-83.
26. Gruber J, Sgonc R, Hu YH, Beug H and Eick G (1994) Thymocyte apoptosis induced by elevated endogenous corticosterone levels. Eur J Immunol 24: 1115-1121.
27. Haba G, Khatami M, Cooper GW, Backlund P and Flaks JG (1999) Alanine or pyruvate is required for the development of myotubes from myoblasts and cortisol satisfies this requirement. Mol Cell Biochem 198: 163-170.
28. Hechter O, Grossman A and Chatterton Jr RT (1997) Relationship of dihydroepiandrosterone and cortisol in disease. Med Hypoth 49: 85-91.
29. Hockenbery DM, Oltvai ZN, Yin XM, Millman LM and Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251.
30. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, Sundaresan M, Finkel T and Goldschmidt-Clermont PJ (1997) Mitogenic signalling mediated by oxidants in Ras-transformed fibroblasts. Science 275: 1649-1652.
31. Jacobson MD, Burne JF and Raff MC (1994) Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J 13: 1899-1910.
32. Jiang D, Iha N, Boonplueang R and Andersen JK (2001) Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells. J Neurochem 76: 1745-1755.
33. Joffroy S, Dourdin N, Delage J-P, Cottin P, Koenig J and Brustis J-J (2000) m-calpain levels increase during fusion of myoblasts in the mutant muscular dysgenesis (mdg) mouse. Int J Dev Biol 44: 421-428.
34. +-influx. Free Rad Biol Med 25: 712-719.
35. Kalimi M, Shafago Y, Loria R, Padgett D and Regelson W (1994) Anti-glucocorticoid effects of dihydroepiandrosterone (DHEA). Mol Cell Biochem 131: 99-104.
36. Kayali AG, Young VR and Goodman MN (1987) Sensitivity of myofibryllar proteins to glucocorticoid-induced muscle proteolysis. Am J Physiol 252 (Endocrinol. Metab. 15): E621-E626.
37. Kim KD, Choe Y-K, Choe IS and Lim J-S (2001) Inhibition of glucocorticoid-mediated, caspase-independent dendritic cell death by CD40 activation. J Leukoc Biol 69: 426-434.
38. Kimura K, Kanda F, Okuda S and Chihara K (2001) Insulin-like growth factor 1 inhibits glucocorticoid-induced glutamine synthetase activity in cultured L6 rat skeletal muscle cells. Neurosci Lett 302: 154-156.
39. Kirsch AH, Mahmood AA, Endres J, Bohra L, Bonish B, Weber K and Fox DA (1999) Apoptosis of human T-cells: induction by glucocorticoids or surface receptor ligation in vitro and ex vivo. J Biol Regul Homeost Agents 13: 80-89.
40. Lankiewicz S, Luetjens CM, Bui NT, Krohn AJ, Poppe M, Cole GM, Saido TC and Prehn JHM (2000) Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J Biol Chem 275: 17,064-17,071.
41. Lassar AB, Skapek SX and Novitch B (1994) Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Curr Opin Cell Biol 6: 788-794.
42. Lawlor MA and Rotwein P (2000) Coordinate control of muscle cell survival by distinct insulin-like growth factor activated signaling pathways. J Cell Biol 151: 1131-1140.
43. Li BG, Fang CH and Hasselgren P-O (2000) Degradation of methoxysuccinyl-phe-leu-phe-7-amido-4-trifluoromethyl coumarin (FLF) in cultured myotubes and HepG2 cells is proteasome- and calpain/calcium-dependent. Int J Biochem Cell Biol 32: 677-686.
44. Lockwood TD (1999) Redox-dependent and redox-independent subcomponents of protein degradation in perfused myocardium. Am J Physiol Endocrinol Metab 276: E945-E954.
45. Mann CL, Hughes FM and Cidlowski J (2000) A Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. Endocrinol 141: 528-538.
46. McGinnis KM, Gnegy ME, Park YH, Mukerjee N and Wang KKW (1999) Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates. Biochem Biophys Res Commun 263: 94-99.
47. Meagher LC, Cousin JM, Seckl JR and Haslett C (1996) Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol 156: 4422-4428.
48. Morris GE and Cole RJ (1979) Calcium and the control of muscle specific creatine kinase accumulation during skeletal muscle differentiation in vitro. Dev Biol 69: 146-158.
49. Naro F, Sette C, Vicini E, Arcangelis VD, Grange M, Conti M, Lagarde M, Molinaro M, Adamo S and Nemoz G (1999) Involvement of type 4 cAMP-phosphodiesterase in the myogenic differentiation of L6 cells. Mol Biol Cell 10: 4355-4367.
50. Nicholson DW (1999) Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Diff 6: 1028-1042.
51. Ono Y, Sorimachi H and Suzuki K (1998) Structure and physiology of calpain, an enigmatic protease. Biochem Biophys Res Commun 245: 289-294.
52. Orzechowski A, Ostaszewski P, Brodnicka A, Wilczak J, Jank M, Bałasińska B, Grzelkowska K, Płoszaj T, Olczak J and Mrówczyńska A (2000) Excess of glucocorticoids impairs whole body antioxidant status in young rats. Relation to the effect of dexamethasone in soleus muscle and spleen. Horm Metab Res 32: 174-180.
53. Pas MFW, de Jong PR and Verburg FJ (2000) Glucocorticoid inhibition of C2C12 proliferation rate and differentiation capacity in relation to mRNA levels of the MRF gene family. Mol Biol Rep 27: 87-98.
54. Ralliere C, Tauveron I, Taillandier D, Guy L, Boiteux J-P, Giraud B, Attaix D and Thieblot P (1997) Glucocorticoids do not regulate the expression of proteolytic genes in skeletal muscle from Cushing's syndrome patients. J Clin Endocrinol Metab 82: 3161-3164.
55. 2+ influx upregulate calpain and induce apoptosis in PC12 cells. Brain Res 852: 326-334.
56. Richard I, Broux O and Allamand V (1995) Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy Type 2A. Cell 81: 27-40.
57. Sainz RM, Mayo JC, Reiter RJ, Antolin I, Esteban MM and Rodriguez C (1999) Melatonin regulates glucocorticoid receptor: an answer to its antiapoptotic action in thymus. FASEB J 13: 1547-1556.
58. Sandri M and Carraro U (1999) Apoptosis of skeletal muscles during development and disease. Int J Biochem Cell Biol 31: 1373-1390.
59. Sarbassov DD, Jones LG and Petersen CA (1997) Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts. Mol Endocrinol 11: 2038-2047.
60. Sarbassov DD and Petersen CA (1998) Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differentiation. Mol Endocrinol 12: 1870-1878.
61. Smith CW, Klaasmeyer JG, Edeal JB, Woods TL and Jones SJ (1999) Effects of serum deprivation, insulin and dexamethasone on polysome percentages in C2C12 myoblasts and differentiating myoblasts. Tissue Cell 31: 451-458.
62. Tharin S, Hamel PA, Conway EM, Michalak M and Opas M (1996) Regulation of calcium binding proteins calreticulin and calsequestrin during differentiation in the myogenic cell line L6. J Cell Physiol 166: 547-560.
63. Thompson EB (1994) Apoptosis and steroid hormones. Mol Endocrinol 8: 665-673.
64. Thompson MG, Thom A, Partridge K, Garden K, Campbell GP, Calder G and Palmer RM (1999) Stimulation of myofobrillar protein degradation and expression of mRNA encoding the ubiquitin-proteasome system in C2C12 myotubes by dexamethasone: effect of the proteasome inhibitor MG-132. J Cell Physiol 181: 455-461.
65. Tomas FM (1998) The anti-catabolic efficacy of insulin-like growth factor-I is enhanced by its early administration to rats receiving dexamethasone. J Endocrinol 157: 89-97.
66. Tome ME, Baker AF, Powis G, Payne CM and Briehl MM (2001) Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth. Cancer Res 61: 2766-2773.
67. Ueda Y, Wang M-C, Ou BR, Huang J, Elce J, Tanaka K, Ichihara A and Forsberg NE (1998) Evidence for the participation of the proteasome and calpain in early phases of muscle cell differentiation. Int J Biochem Cell Biol 30: 679-694.
68. Villa PG, Henzel WJ, Sensebrenner M, Henderson CE and Pettmann B (1998) Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis. J Cell Sci 111: 713-722.
69. Wang L, Luo G-J, Wang J-J and Hasselgren P-O (1998) Dexamethasone stimulates proteasome-, and calcium-dependent proteolysis in cultured L6 myotubes. Shock 10: 298-306.
70. Waters SL, Sarang SS, Wang KKW and Schnellmann RG (1997) Calpains mediate calcium and chloride influx during the late phase of cell injury. J Pharmacol Exp Therap 283: 1177-1184.
71. Weinstein RS, Jilka RL, Parfitt AM and Manolagas SC (1998) Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 102: 274-282.
72. Winter B, Braun T and Arnold HH (1993) cAMP-dependent protein kinase represses myogenic differentiation and the activity of the muscle-specific helix-loop-helix transcription factors Myf-5 and MyoD. J Biol Chem 268: 9869-9878.
73. Yamashima T (2000) Implications of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol 62: 273-295.
74. Yeh J-Y, Ou B-R and Forsberg NE (1994) Effects of dexamethasone on muscle protein homeostasis and on calpain and calpastatin activities and gene expression in rabbits. J Endocrinol 141: 209-217.
75. Zacharchuk CM, Mercep M, Chakraborti PK, Simons Jr SS and Ashwell JD (1990) Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic. J Immunol 145: 4037-4045.