A constitutively active somatic mutation of the human lutropin receptor found in leydig cell tumors activates the same families of g proteins as germ line mutations associated with leydig cell hyperplasia

Endocrinology

Volumn 144, Issue 9, 2003, Pages 3872-3878

  Hirakawa, Takashi ^a   Ascoli, Mario ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; LUTEINIZING HORMONE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; GERM LINE; HUMAN; HUMAN CELL; HYPERPLASIA; LEYDIG CELL TUMOR; MALE; ONCOGENE; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; PROTEIN FUNCTION; SOMATIC MUTATION; WILD TYPE; ANIMAL; CELL CULTURE; DRUG POTENTIATION; GENETICS; METABOLISM; MOUSE; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; TESTIS TUMOR;

ANIMALS; GERM-LINE MUTATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; HYPERPLASIA; LEYDIG CELL TUMOR; MALE; MICE; PUBERTY, PRECOCIOUS; RECEPTORS, LH; TESTICULAR NEOPLASMS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0041920692     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0365     Document Type: Article

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