Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 8, 2003, Pages 2649-2654

  Spreer, Annette ^a   Kerstan, Holger ^a   Böttcher, Tobias ^a   Gerber, Joachim ^a   Siemer, Alexander ^a,e   Zysk, Gregor ^b   Mitchell, Timothy J ^c   Eiffert, Helmut ^a   Nau, Roland ^a,d  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^e BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEFTRIAXONE; CLINDAMYCIN; PNEUMOLYSIN; RIFAMPICIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; BACTERIOLYSIS; BACTERIUM CULTURE; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFANT; INFLAMMATION; MALE; MENINGITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RABBIT; STREPTOCOCCUS PNEUMONIAE;

ADULT; AGED; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CEFTRIAXONE; CEPHALOSPORINS; CHILD, PRESCHOOL; COLONY COUNT, MICROBIAL; CULTURE MEDIA; DEPRESSION, CHEMICAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; MALE; MENINGITIS, PNEUMOCOCCAL; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; RABBITS; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS;

EID: 0041767440     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.8.2649-2654.2003     Document Type: Article

References (29)

1. Alexander, J. E., R. A. Lock, C. C. A. M. Peeters, J. T. Poolman, P. W. Andrew, T. J. Mitchell, D. Hansman, and J. C. Paton. 1994. Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infect. Immun. 62:5683-5688.
2. Balachandran, P., S. K. Hollingshead, J. C. Paton, and D. E. Briles. 2001. The autolytic enzyme LytA of Streptococcus pneumoniae is not responsible for releasing pneumolysin. J. Bacteriol. 183:3108-3116.
3. Berry, A. M., J. Yother, D. E. Briles, D. Hansman, and J. C. Paton. 1989. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect. Immun. 57:2037-2042.
4. Böttcher, T., J. Gerber, A. Wellmer, A. V. Smirnov, F. Fakhrjanali, E. Mix, J. Pilz, U. K. Zettl, and R. Nau. 2000. Rifampin reduces production of reactive oxygen species of cerebrospinal fluid phagocytes and hippocampal neuronal apoptosis in experimental Streptococcus pneumoniae meningitis. J. Infect. Dis. 181:2095-2098.
5. 2 mediate brain cell apoptosis during meningitis. J. Clin. Investig. 109:19-27.
6. 4 by human neutrophils. Infect. Immun. 69:3494-3496.
7. Cockeran, R., A. J. Theron, H. C. Steel, N. M. Matlola, T. J. Mitchell, C. Feldman, and R. Anderson. 2001. Proinflammatory interactions of pneumolysin with human neutrophils. J. Infect. Dis. 183:604-611.
8. Feldman, C., T. J. Mitchell, P. W. Andrew, G. J. Boulnois, R. C. Read, H. C. Todd, P. J. Cole, and R. Wilson. 1990. The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro. Microb. Pathog. 9:275-284.
9. Ferrante, A., B. Rowan-Kelly, and J. C. Paton. 1984. Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin. Infect. Immun. 46:585-589.
10. Gerber, J., H. Eiffert, H. Fleischer, A. Wellmer, U. Munzel, and R. Nau. 2001. Reduced release of DNA from Streptococcus pneumoniae after treatment with rifampin in comparison to spontaneous growth and ceftriaxone treatment. Eur. J. Clin. Microbiol. Infect. Dis. 20:490-493.
11. Hirst, R. A., A. Rutman, K. Sikand, P. W. Andrew, T. J. Mitchell, and C. O'Callaghan. 2000. Effect of pneumolysin on rat brain ciliary function: comparison of brain slices with cultured ependymal cells. Pediatr. Res. 47:381-384.
12. Houldsworth, S., P. W. Andrew, and T. J. Mitchell. 1994. Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1β by human mononuclear phagocytes. Infect. Immun. 62:1501-1503.
13. Jedrzejas, M. J. 2001. Pneumococcal virulence factors: structure and function. Microbiol. Mol. Biol. Rev. 65:187-207.
14. Johnson, M. K. 1977. Cellular location of pneumolysin. FEMS Microbiol. Lett. 2:243-245.
15. Kalin, M., K. Kanclerski, M. Granstrom, and R. Mollby. 1987. Diagnosis of pneumococcal pneumonia by enzyme-linked immunosorbent assay of antibodies to pneumococcal hemolysin (pneumolysin). J. Clin. Microbiol. 25: 226-229.
16. Klugman, K. P., I. R. Friedland, and J. S. Bradley. 1995. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis. Antimicrob. Agents Chemother. 39:1988-1992.
17. Mitchell, T. J., and P. W. Andrew. 1997. Biological properties of pneumolysin. Microb. Drug Resist. 3:19-26.
18. Nahata, M. C., P. Fan-Havard, W. J. Barson, H. M. Bartkowski, and E. J. Kosnik. 1990. Pharmacokinetics, cerebrospinal fluid concentration, and safety of intravenous rifampin in pediatric patients undergoing shunt placement. Eur. J. Clin. Pharmacol. 38:515-517.
19. Nau, R., and W. Brück. 2002. Neuronal injury in bacterial meningitis: mechanisms and implications for therapy. Trends Neurosci. 25:38-45.
20. Nau, R., A. Wellmer, A. Soto, K. Koch, O. Schneider, H. Schmidt, J. Gerber, U. Michel, and W. Brück. 1999. Rifampin reduces early mortality in experimental Streptococcus pneumoniae meningitis. J. Infect. Dis. 179:1557-1560.
21. Paris, M. M., S. Shelton, M. Trujillo, S. M. Hickey, and G. H. McCracken, Jr. 1996. Clindamycin therapy of experimental meningitis caused by penicillin-and cephalosporin-resistant Streptococcus pneumoniae. Antimicrob. Agents Chemother. 40:122-126.
22. Paton, J. C., R. A. Lock, and D. J. Hansman. 1983. Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae. Infect. Immun. 40:548-552.
23. Picardi, J. L., H. P. Lewis, J. L. Tan, and J. P. Phair. 1975. Clindamycin concentrations in the central nervous system of primates before and after head trauma. J. Neurosurg. 43:717-720.
24. Rubins, J. B., T. J. Mitchell, P. W. Andrew, and D. E. Niewoehner. 1994. Pneumolysin activates phospholipase A in pulmonary artery endothelial cells. Infect. Immun. 62:3829-3836.
25. Stringaris, A. K., J. Geisenhainer, F. Bergmann, C. Balshüsemann, U. Lee, G. Zysk, T. J. Mitchell, B. U. Keller, U. Kuhnt, J. Gerber, A. Spreer, M. Bähr, U. Michel, and R. Nau. 2002. Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol. Dis. 11:355-368.
26. Stuertz, K., H. Schmidt, F. Trostdorf, H. Eiffert, M. Mäder, and R. Nau. 1999. Lower lipoteichoic and teichoic acid CSF concentrations during treatment of pneumococcal meningitis with non-bacteriolytic antibiotics than with ceftriaxone. Scand. J. Infect. Dis. 31:367-370.
27. Wellmer, A., G. Zysk, J. Gërber, T. Kunst, M. von Mering, S. Bunkowski, H. Eiffert, and R. Nau. 2002. Decreased virulence of a pneumolysin-deficient strain of Streptococcus pneumoniae in murine meningitis. Infect. Immun. 70:6504-6508.
28. Wheeler, J., R. Freeman, M. Steward, K. Henderson, M. J. S. Lee, N. H. Piggott, G. J. A. Eltringham, and A. Galloway. 1999. Detection of pneumolysin in sputum. J. Med. Microbiol. 48:863-866.
29. Winter, A. J., S. D. Comis, M. P. Osborne, M. J. Tarlow, J. Stephen, P. W. Andrew, J. Hill, and T. J. Mitchell. 1997. A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs. Infect. Immun. 65:4411-4418.