Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis

Journal of Clinical Investigation

Volumn 109, Issue 1, 2002, Pages 19-27

  Braun, Johann S ^a,b   Sublett, Jack E ^a   Freyer, Dorette ^b   Mitchell, Tim J ^c   Cleveland, John L ^a   Tuomanen, Elaine I ^a   Weber, Joerg R ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; PNEUMOLYSIN;

APOPTOSIS; ARTICLE; BACTERIAL INFECTION; BRAIN CELL; CALCIUM CELL LEVEL; CELL DEATH; CELL SURVIVAL; EXTRACELLULAR FLUID; HIPPOCAMPUS; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MENINGITIS; NEUROPROTECTION; PATHOGENICITY; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

EID: 0036141405     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12035     Document Type: Article

References (54)

1. Apoptosis in bacterial pathogenesis
2. Pneumococcal meningitis. Late neurologic sequelae and features of prognostic impact
3. Acute bacterial meningitis in adults. A review of 493 episodes
4. Spectrum of complications during bacterial meningitis in adults. Results of a prospective clinical study
5. Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis
6. Neuronal injury in meningitis
7. Neuroprotection by a caspase inhibitor in acute bacterial meningitis
8. Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis
9. Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus
10. Streptococcus pneumoniae: Virulence factors, pathogenesis, and vaccines
11. Molecular analysis of the pathogenicity of Streptococcus pneumoniae: The role of pneumococcal proteins
12. Pyruvate oxidase as a determinant of virulence in Streptococcus pneumoniae
13. Extracellular targeting of choline-binding proteins in Streptococcus pneumoniae by a zinc metalloprotease
14. The occurrence of peroxide in cultures of pneumococcus
15. Identification of hydrogen peroxide as a Streptococcus pneumoniae toxin for rat alveolar epithelial cells
16. Biological properties of pneumolysin
17. The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus
18. A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs
19. Ventricular involvement in experimental Hemopbilus influenzae meningitis
20. Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
21. Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen
22. Role of nitric oxide in the ethylcholine aziridinium model of delayed apoptotic neurodegeneration in vivo and in vitro
23. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae
24. Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae
25. The com locus controls genetic transformation in Streptococcus pneumoniae
26. Penicillin tolerance genes of Streptococcus pneumoniae: The ABC-type manganese permease complex Psa
27. Identification, cloning, and sequencing of the immunoglobulin A1 protease gene of Streptococcus pneumoniae
28. Multiple antibiotic resistance in a bacterium with suppressed autolytic system
29. Sequential cloning by a vector walking along the chromosome
30. A study of the genetic material determining an enzyme activity in pneumococcus
31. Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages
32. Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes
33. Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome
34. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
35. Molecular characterization of mitochondrial apoptosis-inducing factor
36. 2 in cultured endothelial cells
37. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores
38. Pivotal role of mitochondrial calcium uptake in neuronal cell apoptosis and necrosis
39. Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives
40. The induction of meningeal inflammation by components of the pneumococcal cell wall
41. Relationship of structure to function in pneumolysin
42. Calcium, free radicals and excitotoxins in neuronal apoptosis
43. The mitochondrial permeability transition pore and its role in cell death
44. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
45. Cellular injury by oxidants
46. Inhibitory and bactericidal effects of hydrogen peroxide production by Streptococcus pneumoniae on other inhabitants of the upper respiratory tract
47. The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae
48. Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae
49. Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes
50. Cytocidal effects of Eschericbia coli hemolysin on human T lymphocytes
51. Novel path to apoptosis: Small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation
52. Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis
53. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
54. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus