Proinflammatory interactions of pneumolysin with human neutrophils

Journal of Infectious Diseases

Volumn 183, Issue 4, 2001, Pages 604-611

  Cockeran, Riana ^a   Theron, Annette J ^a   Steel, Helen C ^a   Matlola, Nthane M ^a   Mitchell, Timothy J ^c   Feldman, Charles ^b   Anderson, Ronald ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM 45; EGTAZIC ACID; FORMYLMETHIONYLLEUCYLPHENYLALANINE; PNEUMOLYSIN; RUBIDIUM 86;

ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; CYTOTOXICITY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; INFLAMMATION; MEMBRANE PERMEABILITY; NEUTROPHIL; PRIORITY JOURNAL; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE;

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEINS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CELL DEGRANULATION; ESCHERICHIA COLI; HUMANS; INFLAMMATION; MACROPHAGE-1 ANTIGEN; MEMBRANE POTENTIALS; NA(+)-K(+)-EXCHANGING ATPASE; NEUTROPHILS; PANCREATIC ELASTASE; PHOSPHOLIPASES A; POTASSIUM; RECOMBINANT PROTEINS; STREPTOLYSINS; SUPEROXIDES;

EID: 0035865826     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/318536     Document Type: Article

References (43)

1. The limited role of pneumolysin in the pathogenesis of pneumococcal meningitis
2. Roles of autolysin and pneumolysin in middle ear inflammation caused by a type 3 Streptococcus pneumoniae strain in the chinchilla otitis media model
3. Pneumolysin induces the salient features of pneumococcal infection in the rat lung in vivo
4. Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia
5. Distinct role for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumoniae
6. The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus
7. The role of cytolysin in pneumococcal ocular damage
8. Response of leukopenic rabbits to pneumococcal toxin
9. Effects of pneumolysin on human polymorphonuclear leukocytes and platelets
10. Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin 1β by human mononuclear phagocytes
11. The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro
12. Toxicity of pneumolysin to pulmonary endothelial cells in vitro
13. Toxicity of pneumolysin to pulmonary alveolar epithelial cells
14. Pneumolysin activates phospholipase A in pulmonary artery endothelial cells
15. Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity
16. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae
17. Determination of ATP and ADP in blood platelets: A modification of the firefly luciferase assay for plasma
18. Lucigenin-dependent chemiluminescence as a new assay for NADPH-oxidase activity in particulate fractions of human polymorphonuclear leukocytes
19. Determination of oxidized alpha-1-proteinase inhibitor in serum
20. 2 activity and superoxide generation
21. 2+ indicators with greatly improved fluorescence properties
22. U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells
23. Calcium efflux and influx in f-met-leu-phe (fMLP)-activated human neutrophils are chronologically distinct events
24. Sodium ion influx in proliferating lymphocytes: An early component of the mitogenic signal
25. Tocopherol stabilizes membrane against phospholipase A, free fatty acids and lysophospholipids
26. Inhibition of Na, K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine and oleic acid
27. +adenosine triphosphatase in the mechanism of action of cardiac glycosides
28. Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity and migration by pneumolysin
29. Inhibition of human monocyte respiratory burst, degranulation, phospholipid methylation and bactericidal activity by pneumolysin
30. 4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils
31. Localised and global cytosolic calcium changes in neutrophils during engagement of CD11b CD18 integrin visualised during confocal laser scanning reconstruction
32. Neutrophil signal transduction and activation of the respiratory burst
33. Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils
34. 2+ ionophore A23187-stimulated guinea pig neutrophils
35. Differential sensitivity of pneumolysin-induced channels to gating by divalent cations
36. A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers
37. Effect of calcium ions on staphylococcal alpha-toxin-induced hemolysis of rabbit erythrocytes
38. Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages
39. 2+ response amplitude and duration
40. Host cellular immune response to pneumococcal lung infection in mice
41. Autooxidation as a basis for altered function by polymorphonuclear leukocytes
42. Immunomodulation by neutrophil myeloperoxidase and hydrogen peroxide: Differential susceptibility of human lymphocyte functions