Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome

Molecular and Cellular Biology

Volumn 22, Issue 3, 2002, Pages 856-865

  Morrison, Ashby J ^a   Sardet, Claude ^a   Herrera, Rafael E ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; DNA; HISTONE; HISTONE DEACETYLASE; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DEACETYLATION; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GENE REPRESSION; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONFORMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0036143757     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.3.856-865.2002     Document Type: Article

References (51)

1. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter
2. Affinity chromatographic purification of nucleosomes containing transcriptionally active DNA sequences
3. Factors affecting nucleosome structure in transcriptionally active chromatin. Histone acetylation, nascent RNA and inhibitors of RNA synthesis
4. Reduced levels of histone H3 acetylation on the inactive X chromosome in human females
5. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter
6. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter
7. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern
8. Retinoblastoma protein meets chromatin
9. Retinoblastoma protein recruits histone deacetylase to repress transcription
10. Rapid and reversible changes in nucleosome structure accompany the activation, repression, and superinduction of murine fibroblast protooncogenes c-fos and c-myc
11. Recovery of transcriptionally active chromatin restriction fragments by binding to organomercurial-agarose magnetic beads. A rapid and sensitive method for monitoring changes in higher order chromatin structure during gene activation and repression
12. Opposing roles of pRB and p107 in adipocyte differentiation
13. Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control
14. Control of histone modifications
15. A simplified formaldehyde fixation and immunoprecipitation technique for studying protein-DNA interactions
16. Regulation of cyclin E transcription by E2Fs and retinoblastoma protein
17. Rb function in cell-cycle regulation and apoptosis
18. Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts
19. TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein
20. Chromatin structure analysis of the human c-fos promoter reveals a centrally positioned nucleosome
21. 1 restriction point regulation in Rb-deficient fibroblasts
22. Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction
23. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
24. Hyperacetylation of core histones does not cause unfolding of nucleosomes. Neutron scatter data accords with disc shape of the nucleosome
25. Reconstitution of hyperacetylated. DNase I-sensitive chromatin characterized by high conformational flexibility of nucleosomal DNA
26. Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300
27. Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex
28. Antibodies specific to acetylated histones document the existence of deposition- and transcription-related histone acetylation in Tetrahymena
29. Rb interacts with histone deacetylase to repress transcription
30. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
31. The E2F transcription factors: Key regulators of cell proliferation
32. Targeted and extended acetylation of histones H4 and H3 at active and inactive genes in chicken embryo erythrocytes
33. Rb targets historine H3 methylation and HP1 to promoters
34. Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin
35. Regulation of the cyclin E gene by transcription factor E2F1
36. Analysis of chromatin structure by in vivo formaldehyde cross-linking
37. RNA polymerase II elongation through chromatin
38. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter
39. The periodic down regulation of Cyclin E gene expression from exit of mitosis to end of G(1) is controlled by a deacetylase- and E2F-associated bipartite repressor element
40. Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esal histone acetylase
41. Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects
42. Cancer cell cycles
43. Cell cycle-dependent changes in conformation and composition of nucleosomes containing human histone gene sequences
44. Histone acetylation and transcriptional regulatory mechanisms
45. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
46. Affinity chromatography of mammalian and yeast nucleosomes. Two modes of binding of transcriptionally active mammalian nucleosomes to organomercurial-agarose columns, and contrasting behavior of the active nucleosomes of yeast
47. The retinoblastoma protein and cell cycle control
48. Target gene specificity of E2F and pocket protein family members in living cells
49. Histone H3 thiol reactivity as a probe of nucleosome structure
50. The chromatin structure of specific genes II. Disruption of chromatin structure during gene activity
51. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF