Chemical modification of biocatalysts

Current Opinion in Biotechnology

Volumn 14, Issue 4, 2003, Pages 379-386

  Davis, Benjamin G ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; GLUTATHIONE PEROXIDASE; OXIDOREDUCTASE; PROTEINASE; RIBONUCLEASE; TRIACYLGLYCEROL LIPASE;

AQUEOUS SOLUTION; BIOCATALYST; CATALYSIS; CHEMICAL MODIFICATION; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME STRUCTURE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SITE DIRECTED MUTAGENESIS;

EID: 0041430569     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(03)00098-3     Document Type: Review

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49. •,39].
50. Davis B.G., Sala R.F., Hodgson D.R.W., Ullman A., Khumtaveeporn K., Estell D.A., Sanford K., Bott R.R., Jones J.B. Selective receptor degradation by ligand-targeted enzymes: towards the creation of catalytic antagonists. ChemBioChem. 4:2003;533-537 This use of site-selective modification of a biocatalyst to target-and-destroy proteins presents a generic process by exploiting the intrinsic recognition capabilities of the protein targets and highlights the potential therapeutic application of such an 'affinity cleavage' system.