Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin A gene expression

Molecular Pharmacology

Volumn 64, Issue 2, 2003, Pages 249-258

  Kothapalli, Devashish ^a   Stewart, Sheryl A ^a   Smyth, Emer M ^a   Azonobi, Ijeoma ^b   Puré, Ellen ^b,c   Assoian, Richard K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; CICAPROST; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN A; CYCLIN E; PERTUSSIS TOXIN; PROSTACYCLIN; PROSTACYCLIN RECEPTOR; PROSTANOID; PROTEIN P107; RETINOBLASTOMA PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; AORTA; ARTICLE; CELL ACTIVATION; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; VASCULAR SMOOTH MUSCLE;

AORTA; CELL DIVISION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIN A; CYCLIN E; EPOPROSTENOL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); S PHASE;

EID: 0041341956     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.2.249     Document Type: Article

References (40)

1. Bottazzi ME, Buzzai M, Zhu X, Desdouets C, Brechot C, and Assoian RK (2001) Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity. Mol Cell Biol 21:7607-7616.
2. Bottazzi ME, Zhu X, Bohmer RM, and Assoian RK (1999) Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase. J Cell Biol 146:1255-1264.
3. Cheng Y, Austin SC, Rocca B, Koller BH, Coffman TM, Grosser T, Lawson JA, and FitzGerald GA (2002) Role of prostacyclin in the cardiovascular response to thromboxane A2. Science (Wash DC) 296:539-541.
4. Coleman RA, Grix SP, Head SA, Louttit JB, Mallett A, and Sheldrick RL (1994) A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins 47:151-168.
5. Cuff CA, Kothapalli D, Azonobi I, Chun S, Zhang Y, Belkin R, Yeh C, Secreto A, Assoian RK, Rader DJ, et al. (2001) The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Investig 108:1031-1040.
6. Daaka Y, Luttrell LM, and Lefkowitz RJ (1997) Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature (Lond) 390:88-91.
7. Desdouets C, Matesic G, Molina CA, Foulkes NS, Sassone-Corsi P, Brechot C, and Sobczak-Thepot J (1995) Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM. Mol Cell Biol 15:3301-3309.
8. Diehl JA, Cheng M, Roussel MF, and Sherr CJ (1998) Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12:3499-3511.
9. Doroudi R, Gan LM, Selin Sjogren L, and Jern S (2000) Effects of shear stress on eicosanoid gene expression and metabolite production in vascular endothelium as studied in a novel biomechanical perfusion model. Biochem Biophys Res Commun 269:257-264.
10. Fink AN, Frishman WH, Azizad M, and Agarwal Y (1999) Use of prostacyclin and its analogues in the treatment of cardiovascular disease. Heart Dis 1:29-40.
11. Henglein B, Chenivesse X, Wang J, Eick D, and Brechot C (1994) Structure and cell cycle-regulated transcription of the human cyclin A gene. Proc Natl Acad Sci USA 91:5490-5494.
12. Kam Y, Chow KB, and Wise H (2001) Factors affecting prostacyclin receptor agonist efficacy in different cell types. Cell Signal 13:841-847.
13. 1/S boundary is sequestered by a retinoblastoma-like protein in Go. J Biol Chem 271:6579-6582.
14. q-coupled effector signaling. J Biol Chem 276:33596-33607.
15. Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, and Hla T (2001) Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol Cell 8:693-704.
16. Liu N, Lucibello FC, Engeland K, and Muller R (1998) A new model of cell cycle. regulated transcription: repression of the cyclin A promoter by CDF-1 and antirepression by E2F. Oncogene 16:2957-2963.
17. Mayr B and Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599-609.
18. McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, and FitzGerald GA (1999) Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci USA 96:272-277.
19. Motamed K, Funk SE, Koyama H, Ross R, Raines EW, and Sage EH (2002) Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors. J Cell Biochem 84:759-771.
20. Nagahara H, Ezhevsky SA, Vocero-Akbani AM, Kaldis P, Solomon MJ, and Dowdy SF (1999) Transforming growth factor beta targeted inactivation of cyclin E: cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proc Natl Acad Sci USA 96:14961-14966.
21. Namba T, Oida H, Sugimoto Y, Kakizuka A, Negishi M, Ichikawa A, and Narumiya S (1994) cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J Biol Chem 269:9986-9992.
22. Narumiya S, Sugimoto Y, and Ushikubi F (1999) Prostanoid receptors: structures, properties and functions. Physiol Rev 79:1193-1226.
23. Reynisdottir I, Polyak K, Iavarone A, and Massague J (1995) Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9:1831-1845.
24. Roovers K and Assoian RK (2000) Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22:818-826.
25. Roovers K, Davey G, Zhu X, Bottazzi ME, and Assoian RK (1999) Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. Mol Biol Cell 10:3197-3204.
26. Schulze A, Mannhardt B, Zerfass-Thome K, Zwerschke W, and Jansen-Durr P (1998) Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16. J Virol 72:2323-2334.
27. s proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL. Biochim Biophys Acta 1265:8-14.
28. Sherr CJ and Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512.
29. Shimizu M, Nomura Y, Suzuki H, Ichikawa E, Takeuchi A, Suzuki M, Nakamura T, Nakajima T, and Oda K (1998) Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4. Exp Cell Res 239:93-103.
30. Smyth EM, Nestor PV, and FitzGerald GA (1996) Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor. J Biol Chem 271:33698-33704.
31. 2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev 8:2527-2539.
32. Takahashi Y, Rayman JB, and Dynlacht BD (2000) Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev 14:804-816.
33. Tobin AB (2002) Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation. Trends Pharmacol Sci 23:337-343.
34. Topper JN, Cai J, Falb D, and Gimbrone MA Jr (1996) Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 93:10417-10422.
35. Vousden K (1993) Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes. FASEB J 7:872-879.
36. Weber AA, Zucker TP, Hasse A, Bonisch D, Wittpoth M, and Schror K (1998) Antimitogenic effects of vasodilatory prostaglandins in coronary artery smooth muscle cells. Basic Res Cardiol 93:54-57.
37. Welsh CF, Roovers K, Villanueva J, Liu Y, Schwartz MA, and Assoian RK (2001) Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 3:950-957.
38. Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, et al. (2001) The E2F1-3 transcription factors are essential for cellular proliferation. Nature (Lond) 414:457-462.
39. Zhu X, Ohtsubo M, Bohmer RM, Roberts JM, and Assoian RK (1996) Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2 and phosphorylation of the retinoblastoma protein. J Cell Biol 133:391-403.
40. Zwicker J, Lucibello FC, Wolfraim LA, Gross C, Truss M, Engeland K, and Muller R (1995) Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO (Eur Mol Biol Organ) J 14:4514-4522.