Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray

British Journal of Cancer

Volumn 88, Issue 9, 2003, Pages 1417-1423

  Hedberg, Y ^a   Ljungberg, B ^a   Roos, G ^a   Landberg, G ^b  

^a UMEÅ UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Cell cycle; Cyclin; G1 S transition; Protein; Renal cell carcinoma; Tissue microarray

Indexed keywords

CYCLIN D1; CYCLIN D3; CYCLIN E; PROTEIN P27;

ADULT; AGED; ARTICLE; CANCER GRADING; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; FEMALE; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MALE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN CONTENT; TISSUE MICROARRAY; TUMOR VOLUME; WESTERN BLOTTING;

ACTUARIAL ANALYSIS; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; CELL CYCLE; CYCLIN D1; CYCLIN E; CYCLINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUSCLE PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 0038823526     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600922     Document Type: Article

References (33)

1. Aaltomaa S, Lipponen P, Ala-Opas M, Eskelinen M, Syrjanen K, Kosma VM (1999) Expression of cyclins A and D and p21(waf1/cip1) proteins in renal cell cancer and their relation to clinicopathological variables and patient survival. Br J Cancer 80: 2001-2007
2. Åkervall JA, Michalides RJ, Mineta H, Balm A, Borg A, Dictor MR, Jin Y, Loftus B, Mertens F, Wennerberg JP (1997) Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression. Cancer 79: 380-389
3. Bartkova J, Zemanova M, Bartek J (1996) Abundance and subcellular localisation of cyclin D3 in human tumours. Int J Cancer 65: 323-327
4. Camp RL, Charette LA, Rimm DL (2000) Validation of tissue microarray technology in breast carcinoma. Lab Invest 80: 1943-1949
5. Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (1995) Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). Cytogenet Cell Genet 69: 190-192
6. Gansauge S, Gansauge F, Ramadani M, Stobbe H, Rau B, Harada N, Beger HG (1997) Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res 57: 1634-1637
7. Gillett C, Smith P, Gregory W, Richards M, Millis R, Peters G, Barnes D (1996) Cyclin D1 and prognosis in human breast cancer. Int J Cancer 69: 92-99
8. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA (1999) Creation of human tumour cells with defined genetic elements. Nature 29: 464-468
9. Harbour JW, Dean DC (2000) Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2: E65-E67
10. Hedberg Y, Davoodi E, Roos G, Ljungberg B, Landberg G (1999) Cyclin D1 expression in renal cell carcinoma. Int J Cancer 84: 268-272
11. Hedberg Y, Roos G, Ljungberg B, Landberg G (2002a) Cyclin D3 protein content in human renal cell carcinoma in relation to cyclin D1 and clinico-pathological parameters. Acta Oncol 41: 175-181
12. Hedberg Y, Davoodi E, Ljunberg B, Roos G, Landberg G (2002b) Aberrant cyclin E and p27 protein content in human renal cell carcinoma. Clinical outcome and associations with cyclin D. Int J Cancer 102: 601-607
13. Hommura F, Dosaka-Akita H, Mishina T, Nishi M, Kojima T, Hiroumi H, Ogura S, Shimizu M, Katoh H, Kawakami Y (2000) Prognostic significance of p27KIP1 protein and Ki-67 growth fraction in non-small cell lung cancers. Clin Cancer Res 6: 4073-4081
14. Hwang CF, Cho CL, Huang CC, Wang JS, Shih YL, Su CY, Chang HW (2002) Loss of cyclin D1 and p16 expression correlates with local recurrence in nasopharyngeal carcinoma following radiotherapy. Ann Oncol 13: 1246-1251
15. Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (1992) Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics 13: 565-574
16. Kallioniemi OP, Wagner U, Kononen J, Sauter G (2001) Tissue microarray technology for high-throughput molecular profiling of cancer. Hum Mol Genet 10: 657-662
17. Kawauchi S, Goto Y, Liu XP, Furuya T, Oga A, Oda Y, Tsuneyoshi M, Ihara K, Sasaki K (2001) Low expression of p27(Kip1), a cyclin-dependent kinase inhibitor, is a marker of poor prognosis in synovial sarcoma. Cancer 91: 1005-1012
18. Keyomarsi K, Conte Jr D, Toyofuku W, Fox MP (1995) Deregulation of cyclin E in breast cancer. Oncogene 11: 941-950
19. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP (1998) Tissue microarrays for high-throughput molecular profiling of tumour specimens. Nat Med 4: 844-847
20. Kovacs G, Akhtar M, Beckwith BJ, Bugert P, Cooper CS, Delahunt B, Eble JN, Fleming S, Ljungberg B, Medeiros LJ, Moch H, Reuter VE, Ritz E, Roos G, Schmidt D, Srigley JR, Storkel S, van den Berg E, Zbar B (1997) The Heidelberg classification of renal cell tumors. J Pathol 183: 131-133
21. Lai S, Benedict WF, Silver SA, El-Naggar AK (1997) Loss of retinoblastoma gene function and heterozygosity at the RB locus in renal cortical neoplasms. Hum Pathol 28: 693-697
22. Larsson P, Roos G, Stenling R, Ljungberg B (1996) Proliferating cell nuclear antigen expression in renal cell carcinoma. Prognostic implications. Scand J Urol Nephrol 30: 445-450
23. Lees E (1995) Cyclin dependent kinase regulation. Curr Opin Cell Biol 7: 773-780
24. Ljungberg B, Mehle C, Stenling R, Roos G (1996) Heterogeneity in renal cell carcinoma and its impact on prognosis - a flow cytometric study. Br J Cancer 74: 123-127
25. McKay JA, Douglas JJ, Ross VG, Curran S, Loane JF, Ahmed FY, Cassidy J, McLeod HL, Murray GI (2002) Analysis of key cell-cycle checkpoint proteins in colorectal tumours. J Pathol 196: 386-393
26. Moch H, Schraml P, Bubendorf L, Mirlacher M, Kononen J, Gasser T, Mihatsch MJ, Kallioniemi OP, Sauter G (1999) High-throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma. Am J Pathol 154: 981-986
27. Nielsen NH, Emdin SO, Cajander J, Landberg G (1997) Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein. Oncogene 14: 295-304
28. Nielsen NH, Arnerlov C, Cajander S, Landberg G (1998) Cyclin E expression and proliferation in breast cancer. Anal Cell Pathol 17: 177-188
29. Presti Jr JC, Reuter VE, Cordon-Cardo C, Motzer RJ, Albino AP, Jhanwar SC, Nanus DM (1996) Expression of the retinoblastoma gene product in renal tumours. Anticancer Res 16: 549-556
30. Reed SI (1997) Control of the G1/S transition. Cancer Surv 29: 7-23
31. Sherr CJ (2000) The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 60: 3689-3695
32. Skinner DG, Colvin RB, Vermillon CD, Pfister RC, Leadbetter WF (1971) Diagnosis and management of renal cell carcinoma. A clinical and pathological study of 309 cases. Cancer 28: 1165-1177
33. Sobin LH, Wittekind CH (1997) TNM Classification of Malignant Tumours, 5th ed., pp 180-182 New York: International Union Against Cancer (UICC)