Low expression of p27kip1, a cyclin-dependent kinase inhibitor, is a marker of poor prognosis in synovial sarcoma

Cancer

Volumn 91, Issue 5, 2001, Pages 1005-1012

  Kawauchi, Shigeto ^a   Goto, Yoshinari ^a   Liu, Xiu Ping ^a   Furuya, Tomoko ^a   Oga, Atsunori ^a   Oda, Yoshinao ^b   Tsuneyoshi, Masazumi ^b   Ihara, Koichiro ^a   Sasaki, Kohsuke ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Cyclin dependent kinase inhibitor; Immunohistochemistry; p27kip1; Synovial sarcoma

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1B; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; CANCER STAGING; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MITOSIS INDEX; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SURVIVAL; SYNOVIAL SARCOMA; TUMOR GROWTH;

ADOLESCENT; ADULT; AGED; CELL CYCLE; CELL CYCLE PROTEINS; CHILD; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MITOTIC INDEX; PROGNOSIS; SARCOMA, SYNOVIAL; SOFT TISSUE NEOPLASMS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 0035281785     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20010301)91:5<1005::AID-CNCR1091>3.0.CO;2-O     Document Type: Article

References (34)

1. Mutations of cell cycle regulators
2. Cancer cell cycles
3. G1 events and regulation of cell proliferation
4. Inhibitors of cyclin dependent kinase and cancer
5. kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
6. kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
7. kip1, a cyclin-cdk inhibitor, links transforming growth factor-b and contact inhibition to cell cycle arrest
8. p27, a novel inhibitor of G1 cyclincdk protein kinase activity is related to p21
9. kip1 chromosomal mapping to 12p 12-12p 13.1 and absence of mutations in human tumors
10. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
11. kip1
12. kip1 expression in rodent pituitary cell lines
13. Synovial sarcoma
14. Ki-67 is strongly prognostic in synovial sarcoma: Analysis based on 86 patients from the Scandinavian sarcoma group register
15. The prognostic value of immunohistochemical staining for proliferating cell nuclear antigen in synovial sarcoma
16. Prognostic significance of apoptosis in synovial sarcoma: Correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related proteins
17. A clinical and pathological staging system for soft tissue sarcomas
18. Survival in synovial sarcoma: A multivariate study of prognostic factors with special emphasis on the comparison between early death and long-term survival
19. kip1 in malignant melanoma: Inverse correlation with disease free survival
20. kip1 protein: Prognostic implications in primary breast cancer
21. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinoma
22. Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma
23. p27 expression and gastric carcinoma
24. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
25. kip1 and Ki-67 in benign and malignant thyroid tumors
26. Alterations of cell cycle regulators in localized synovial sarcoma: A multifactorial study with prognostic implications
27. Expression of cell cycle inhibitor p27 and Ki-67 in human adrenocortical neoplasms
28. Expression of cell-cycle regulatory gene products in conventional gastric adenomas: Possible immunohistochemical markers of malignant transformation
29. Kip1 in Kaposi's sarcoma correlates with higher stage and extracutaneous involvement
30. Specific phenotyping of T-cell proliferations in formalin-fixed paraffinembedded tissues: Use of antibodies to the T-cell receptor beta F1
31. A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification
32. Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas
33. Angiogenesis in endometrial carcinoma
34. Promoting apoptosis: A novel activity associated with the cyclin-dependent kinase inhibitor p27