Loss of retinoblastoma gene function and heterozygosity at the RB locus in renal cortical neoplasms

Human Pathology

Volumn 28, Issue 6, 1997, Pages 693-697

  Lai, Syeling ^b   Benedict, William F ^b   Silver, Susan A ^b   El Naggar, Adel K ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NONE

Author keywords

Immunohistochemistry; Loss of heterozygosity; Renal cell carcinoma; Restriction fragment length polymorphism; Retinoblastoma

Indexed keywords

RETINOBLASTOMA PROTEIN;

ADULT; AGED; ANEUPLOIDY; ARTICLE; CHROMOSOME 13Q; CLINICAL ARTICLE; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; KIDNEY TUMOR; MALE; ONCOCYTOMA; TUMOR SUPPRESSOR GENE;

EID: 0030911222     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(97)90178-7     Document Type: Article

References (41)

1. Friend SH, Horowitz JM, Gerber MR, et al: Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encode protein. Proc Natl Acad Sci U S A 84:9059-9063, 1987
2. Fung YK, Murphree AL, T'Ang A, et al: Structural evidence for the authenticity of the human retinoblastoma gene. Science 236:1657-1661, 1987
3. Lee WH, Bookstein R, Hong F, et al: Human retinoblastoma susceptibility gene: Cloning, identification, and sequencing. Science 235:1394-1399, 1987
4. Cavenee WK, Dryja TP, Phillips RA, et al: Expression of recessive alleles by chromosomal mechanisma in retinoblasoma. Nature 305:779-784, 1983
5. Dryja TP, Rapaport JM, Joyce JM, et al: Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas. Proc Natl Acad Sci U S A 83:7391-7394, 1986
6. Knudson AG: Mutation and cancer in man. Cancer 39:1882-1886, 1977
7. Ewen ME: The cell cycle and the retinoblastoma protein family. Cancer Metastasis Rev 13:45-66, 1994
8. Wang JY, Knudsen ES, Welch PJ: The retinoblastoma tumor suppressor protein. Adv Cancer Res 64:25-85, 1994
9. Harbour JW, Lai SL, Whang-Peng J, et al: Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241:353-357, 1988
10. Yokota J, Akiyama T, Fung YK, et al: Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. Oncogene 3:471-475, 1988
11. Xu HJ, Hu SX, Cagle PT, et al: Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res 51:2735-2739, 1991
12. Xu HJ, Cairns P, Hu SX, et al: Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the rb locus and tumor progression. Int J Cancer 53:781-784, 1993
13. Cordon-Cardo C, Wartzinger D, Petrylak D, et al: Altered expression of the retinoblastoma gene product: Prognostic indicator in bladder cancer. J Natl Cancer Inst 84:1251-1256, 1992
14. Xu H-J, Quinlan DC, Davidson AG, et al: Altered retinoblastoma protein expression and prognosis in early-stage non-small cell lung carcinoma. J Natl Cancer Inst 86:695-699, 1994
15. Toguchida J, Ishizaki K, Sasaki et al: Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. Cancer Res 48:3939-3943, 1988
16. Cryns VL, Thor A, Xu HJ, et al: Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med 330:757-761, 1994
17. Lipponen PK, Liukkonen TJ: Reduced expression of retinoblastoma (Rb) gene protein is related to cell proliferation and prognosis in transitional-cell bladder cancer. Cancer Res Clin Oncol 121:44-50, 1995
18. Zhang X, Xu H-J, Murahami Y, et al: Deletions of chromosome 13q mutations in RB1 and RB protein state in human hepatocellular carcinoma. Cancer Res 54:4177-4182, 1994
19. Henson JW, Schnitker BL, Correa KM, et al: The retinoblastoma gene is involved in malignant progression of astrocytomas. Ann Neurol 36:714-721, 1994
20. Barton CM, McKie AB, Hogg A, et al: Abnormalities of the RB1 and DCC tumor suppressor genes; uncommon in human pancreatic adenocarcinoma. Mol Carcinog 13:61-69, 1995
21. Constancia M, Seruca R, Carneiro F, et al: Retinoblastoma gene structure and product expression in human gastric carcinoma. Br J Cancer 70:1018-1024, 1994
22. Dodson MK, Cliby WA, Xu HJ, et al: Evidence of functional Rb protein in epithelial ovarian carcinomas despite loss of heterozygosity at the Rb locus. Cancer Res 54:610-613, 1994
23. Kim TM, Benedict WF, Xu H-J, et al: Loss of heterozygosity on chromosome 13q is associated with the biologically more agressive subtypes of ovarian epithelial tumors and do not result in loss of retinoblastoma gene expression. Cancer Res 54:605-609, 1994
24. Yoo GH, Xu HJ, Brennan JA, et al: Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma. Cancer Res 54:4603-4606, 1994
25. Pei L, Melmed S, Scheithauer B, et al: Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumor: Evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res 55:1613-1616, 1995
26. Brooks JD, Bova GS, Marshall FF, et al: Tumor suppressor gene allelic loss in human renal cancers. J Urol 150:1278-1283, 1993
27. Geradts J, Hu SX, Lincoln CE, et al: Aberrant Rb gene expression in routinely processed, archival tumor tissues determined by three different anti-Rb antibodies. Int J Cancer 58:161-167, 1994
28. Ishikawa J, Xu HJ, Hu SX, et al: Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas. Cancer Res 51:5736-5743, 1991
29. Shuin T, Torigoe S, Kubota Y, et al: Retinoblastoma gene mutation in primary human renal cell carcinoma. Oncol Res 7:63-66, 1995
30. Walter MM, Gnarra JR, Elwood L, et al: Loss of heterozygosity occurs centromeric to RB without associated abnormalities in the retinoblastoma gene in tumors from patients with metastatic renal cell carcinoma. J Urol 153:2050-2054, 1995
31. Fuhrman SA, Lasky LC, Limas CL: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655-663, 1982
32. Robson C, Churchill B, Anderson W: The results of radical nephrectomy for renal cell carcinoma. J Urol 101:297-301, 1969
33. Boynton RF, Huang Y, Blount PL, et al: Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers. Cancer Res 51:5766-5769, 1991
34. Lai S, Asgari M, Henney HR: Nonradioactive DNA probe and polymerase chain reaction procedures for the specific detection of acanthamoeba. Mol Cell Probes 8:81-89, 1994
35. Lai S, Batsakis JG, Ordonez NG, et al: Genotypic and phenotypic alterations of p53 in head and neck squamous cell carcinoma. Oncol Report 2:1115-1120, 1995
36. Hsu SM, Fancer H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and the unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580, 1981
37. Cattoretti G, Becker MHG, Key G, et al: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB and MIB 3) detect proliferating cells in microwave-processed, formalin-fixed paraffin sections. J Pathol 168:357-363, 1992
38. Cattoretti G, Pileri S, Parraviccini C, et al: Antigen unmasking of formalin-fixed, paraffin-embedded tissue sections. J Pathol 171:83-98, 1993
39. Xu H-J, Hu S-X, Hashimoto T, et al: The retinoblastoma susceptibility gene product: A characteristic pattern in normal cells and abnormal expression in malignant cells. Oncogene 4:807-812, 1989
40. Xu H-JH: Altered retinoblastoma (RB) protein expression in human malignancies. Adv Anat Pathol 2:213-226, 1995
41. Traganos F, Darzynkiewicz Z, Sharpless T, et al: Simultaneous staining of ribonucleic and deoxyribonucleic acids in unfixed cells using acridine orange in a flow cytofluorometric system. J Histochem 25:46-56, 1977