Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy

Epilepsy Research

Volumn 54, Issue 2-3, 2003, Pages 97-107

  Richards, Douglas A ^a   Manning, Jon Paul A ^a   Barnes, David ^a   Rombola, Laura ^b   Bowery, Norman G ^a   Caccia, Silvio ^c   Leresche, Nathalie ^d   Crunelli, Vincenzo ^e  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF CALABRIA   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d SORBONNE UNIVERSITÉ   (France)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Absence epilepsy; Ethosuximide; Microdialysis; Reticular thalamic nucleus; Spike wave discharge; Ventrobasal thalamic complex

Indexed keywords

3 AMINOPROPYLBUTYLPHOSPHINIC ACID; ETHOSUXIMIDE;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; DRUG EFFECT; DRUG INFUSION; DRUG MECHANISM; DRUG TARGETING; ELECTROENCEPHALOGRAPHY; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPIKE WAVE; TARGET ORGAN; THALAMUS NUCLEUS;

EID: 0038771143     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(03)00060-3     Document Type: Article

References (43)

1. Andren P.E., Emmett M.R., DaGue B.B., Steulet A.-F., Waldmeier P.C., Caprioli R.M. Blood-brain barrier penetration of 3-aminopropyl-n-butylphosphinic acid (CGP 36742) in rat brain by microdialysis/mass spectrometry. J. Mass Spectrom. 33:1998;281-287.
2. + channels in hippocampal CA1 pyramidal neurons. J. Neurophysiol. 77:1997;1023-1028.
3. Bal T., Debay D., Destexhe A. Cortical feedback controls the frequency and synchrony of oscillations in the visual thalamus. J. Neurosci. 20:2000;7478-7488.
4. Blumenfeld H., McCormick D.A. Corticothalamic inputs control the pattern of activity generated in thalamocortical networks. J. Neurosci. 20:2000;5153-5162.
5. Chang, T., 1989a. Ethosuximide: absorption, distribution, and excretion. In: Levy, R., Mattson, R., Meldrum, B., Penry, J.K., Dreifuss, F.E. (Eds.), Antiepileptic Drugs. Raven Press, New York, pp. 671-678.
6. Chang, T., 1989b. Ethosuximide: biotransformation. In: Levy, R., Mattson, R., Meldrum, B., Penry, J.K., Dreifuss, F.E. (Eds.), Antiepileptic Drugs. Raven Press, New York, pp. 679-683.
7. Coenen A.M.L., Drinkenburg W.H.I.M., Inoue M., van Luijtelaar E.L.J.M. Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats. Epilepsy Res. 12:1992;75-86.
8. Coenen A.M.L., van Luijtelaar E.L.J.M. The WAG/Rij rat model for absence epilepsy: age and sex factors. Epilepsy Res. 1:1987;297-301.
9. Coulter D.A., Huguenard J.R., Prince D.A. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann. Neurol. 25:1989;582-593.
10. Coulter D.A., Huguenard J.R., Prince D.A. Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br. J. Pharmacol. 100:1990;800-806.
11. B receptors in excitation and inhibition of thalamocortical cells. Trends Neurosci. 14:1991;16-21.
12. 2+ channels by ethosuximide is not the entire story. Epilepsy Curr. 2:2002a;53-56.
13. Crunelli V., Leresche N. Childhood absence epilepsy: genes, channels, neurons and networks. Nature Rev. Neurosci. 3:2002b;371-382.
14. Danober L., Deransart C., Depaulis A., Vergnes M., Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog. Neurobiol. 55:1998;27-57.
15. Gomora J.C., Daud A.N., Weiergraber M., Perez-Reyes E. Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol. Pharmacol. 60:2001;1121-1132.
16. B receptors regulate absence seizures in the lethargic (lh/lh) mouse model. J. Neurosci. 15:1995;7367-7376.
17. Hughes S.W., Cope D.W., Blethyn K., Crunelli V. Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro. Neuron. 33:2002;947-958.
18. 2+ channels is an important action of succinimide anti-absence drugs. Epilepsy Curr. 2:2002;49-52.
19. Huguenard J.R., Prince D.A. Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J. Neurosci. 14:1994;5485-5502.
20. 2+ channels. Neuron. 31:2001;35-45.
21. 1G subunit by divalent cations and organic blocker. Neuropharmacology. 39:2000;1254-1266.
22. Leresche N., Parri H.R., Erdemli G., Guyon A., Turner J.P., Williams S.R., Asprodini E., Crunelli V. On the action of the anti-absence drug ethosuximide in the rat and cat thalamus. J. Neurosci. 18:1998;4842-4853.
23. B neurotransmission in the control of absence seizures in the rat. Neuroscience. 48:1992;87-93.
24. Manning J.-P.A., Richards D.A., Bowery N.G. Anti-absence action of ethosuximide administered via reverse microdialysis into the ventrobasal thalamus of the genetic absence epilepsy rat from Strasbourg (GAERS). FENS Abstr. 1:2002;A223.8.
25. Marescaux C., Micheletti G., Vergnes M., Depaulis A., Rumbach L., Warter J.M. A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures. Epilepsia. 25:1984;326-331.
26. Marescaux C., Vergnes M., Depaulis A. Genetic absence epilepsy in rats from Strasbourg - a review. J. Neural Transm. Suppl. 35:1992;7-69.
27. Meeren H.K.M., Pijn J.P.M., van Luijtelaar E.L.J.M., Coenen A.M.L., Lopes da Silva F.H. Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J. Neurosci. 22:2002;1480-1495.
28. Panayiotopoulos, C.P., 1997. Absence epilepsies. In: Engel, J., Pedley, T.A. (Eds.), Epilepsy: A Comprehensive Textbook. Lippincott-Raven, Philadelphia, pp. 2327-2346.
29. Pfrieger F.W., Veselovsky N.S., Gottmann K., Lux H.D. Pharmacological characterization of calcium currents and synaptic transmission between thalamic neurons in vitro. J. Neurosci. 12:1992;4347-4357.
30. T and slow intrathalamic rhythms. J. Neurophysiol. 89:2003;177-185.
31. Richards, D.A., Bowery, N.G., Manning, J.-P.A., Spruce, A.E., Leresche, N., Crunelli, V., 2001. Weak anti-absence activity of ethosuximide infused directly into different thalamic nuclei of absence epilepsy rats. In: Proceedings of the 31st Annual Meeting of the Society for Neuroscience, vol. 27, p. 969.8.
32. Richards D.A., Lemos T., Whitton P.S., Bowery N.G. Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: a microdialysis study. J. Neurochem. 65:1995;1674-1680.
33. Sayer R.J., Brown A.M., Schwindt P.C., Crill W.E. Calcium currents in acutely isolated human neocortical neurons. J. Neurophysiol. 69:1993;1596-1606.
34. Sherwin, A.L., 1989. Ethosuximide: clinical use. In: Levy, R., Mattson, R., Meldrum, B., Penry, J.K., Dreifuss, F.E. (Eds.), Antiepileptic Drugs. Raven Press, New York, pp. 685-698.
35. B-mediated mechanisms in experimental generalized absence seizures. Eur. J. Pharmacol. 213:1992;343-349.
36. Snead O.C. Basic mechanisms of generalised absence seizures. Ann. Neurol. 37:1995;146-157.
37. Sohal V.S., Huguenard J.R. It takes T to tango. Neuron. 31:2001;3-4.
38. B antagonist 3-amino-propyl-n-butyl-phosphinic acid (CGP 36742) by a new GC/MS method. Biochem. Pharmacol. 51:1996;613-619.
39. Talley E.M., Solorzano G., Depaulis A., Perez-Reyes E., Bayliss D.A. Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat. Mol. Brain Res. 75:2000;159-165.
40. Thompson S.M., Wong R.K.S. Development of calcium current subtypes in isolated rat hippocampal pyramidal cells. J. Physiol. 439:1991;671-689.
41. B receptor antagonists on absences and convulsive seizures. Eur. J. Pharmacol. 332:1997;245-255.
42. Vergnes M., Marescaux C., Micheletti G., Reis J., Depaulis A., Rumbach L., Warter J.M. Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy. Neurosci. Lett. 33:1982;97-101.
43. Westerink B.H.C., De Vries J.B. A method to evaluate the diffusion rate of drugs from a microdialysis probe through brain tissue. J. Neurosci. Methods. 109:2001;53-58.