Review article: Delaying the mitochondrial decay of aging - A metabolic tune-up

Alzheimer Disease and Associated Disorders

Volumn 17, Issue SUPPL. 2, 2003, Pages

  Ames, Bruce N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCARNITINE; ALDEHYDE; ALPHA TOCOPHEROL; ASCORBIC ACID; CARDIOLIPIN; CARNITINE ACETYLTRANSFERASE; CYANOCOBALAMIN; CYTOCHROME C OXIDASE; DNA; FLAVINE ADENINE NUCLEOTIDE; FOLIC ACID; HOMOCYSTEINE; IRON; MALONALDEHYDE; MINERAL; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINIC ACID; OXIDIZING AGENT; PROTEIN P53; PYRIDOXINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RNA; SELENIUM; THIOCTIC ACID; TRACE ELEMENT; UNINDEXED DRUG; URACIL; VITAMIN; VITAMIN B GROUP; ZINC;

AGING; BINDING AFFINITY; CHROMOSOME BREAKAGE; COENZYME; COGNITIVE DEFECT; CONFERENCE PAPER; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA POLYMORPHISM; DNA REPAIR; ENZYME BINDING; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; IRON INTAKE; METABOLISM; METABOLITE; MINERAL INTAKE; MITOCHONDRIAL RESPIRATION; NERVE DEGENERATION; NONHUMAN; NUTRITIONAL DEFICIENCY; OXIDATION; PRIORITY JOURNAL; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; MITOCHONDRION; NUTRITIONAL STATUS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; VITAMIN DEFICIENCY;

AGING; AVITAMINOSIS; COGNITION DISORDERS; DNA DAMAGE; DNA REPAIR; HUMANS; MITOCHONDRIA; NUTRITIONAL STATUS;

EID: 0038647794     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-200304002-00007     Document Type: Conference Paper

References (36)

1. Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 2001;475:7-20.
2. Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr 2002;75:616-58.
3. Ames BN, Gold LS. Paracelsus to parascience: the environmental cancer distraction. Mutat Res 2000;447:3-13.
4. Ames BN, Wakimoto P. Are vitamin and mineral deficiencies a major cancer risk? Nature Rev Cancer 2002;2:694-704.
5. Atamna H, Killilea DW, Killilea AN, Ames BN. Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc Natl Acad Sci USA 2002a;99:14807-12.
6. Atamna H, Liu J, Ames BN. Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: relevance to aging. J Biol Chem 2001;276:48410-6.
7. Atamna H, Walter PB, Ames BN. The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. Arch Biochem Biophys 2002b;397:345-53.
8. Beckman KB, Ames BN. Mitochondrial aging: open questions. Ann NY Acad Sci 1998a;854:118-27.
9. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 1998b;78:547-81.
10. Benton D. Micro-nutrient supplementation and the intelligence of children. Neurosci Biobehav Rev 2001;25:297-309.
11. Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997;94:3290-5.
12. Crott JW, Mashiyama ST, Ames BN, Fenech M. The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol Biomarkers Prev 2001a;10:1089-96.
13. Crott JW, Mashiyama ST, Ames BN, Fenech MF. Methylenetetrahy-drofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis 2001b;22:1019-25.
14. Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 2002;75:908-13.
15. Frith-Terhune AL, Cogswell ME, Khan LK, Will JC, Ramakrishnan U. Iron deficiency anemia: higher prevalence in Mexican American than in non-Hispanic white females in the third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2000;72:963-8.
16. Gamoh S, Hashimoto M, Sugioka K, et al. Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience 1999;93:237-41.
17. Hagen TM, Ingersoll RT, Liu J, et al. (R)-alpha-lipoic-acid supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J 1998a;13:411-8.
18. Hagen TM, Liu J, Lykkesfeldt J, et al. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci USA 2002;99:1870-5.
19. Hagen TM, Ingersoll RT, Wehr CM, et al. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci USA 1998b;95:9562-6.
20. Hagen TM, Vinarsky V, Wehr CM, Ames BN. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal 2000;2:473-83.
21. Hagen TM, Wehr CM, Ames BN. Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tertbutyl-alpha-phenyl nitrone. Ann NY Acad Sci 1998c;854:214-23.
22. Hagen TM, Yowe DL, Bartholomew JC, et al. Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci USA 1997;94:3064-9.
23. Helbock HJ, Beckman KB, Shigenaga MK, et al. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxodeoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci USA 1998;95:288-93.
24. Ho E, Ames BN. Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci USA 2002;99:16770-5.
25. Ho E, Courtemanche C, Ames BN. Zinc deficiency induces oxidative DNA damage and increase p53 expression in human lung fibroblasts. J Nutr 2003;133.
26. Kumanyika SK, Krebs-Smith SM. Preventive nutrition issues in ethnic and socioeconomic groups in the United States. In: Bendich A, Deckelbaum RJ, eds. Primary and secondary preventive nutrition. Totowa, NJ: Humana Press, 2001:325-56.
27. Kyle DJ, Schaefer E, Patton G, Beiser A. Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia [abstract]. Lipids 1999;34(suppl):S245.
28. Liu J, Head E, Gharib AM, et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci USA 2002a;99:2356-61.
29. Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci USA 2002b;99:1876-81.
30. Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes - reversal with (R)-alpha-lipoic acid supplementation. FASEB J 1998;12:1183-9.
31. Sandstead HH, Frederickson CJ, Penland JG. History of zinc as related to brain function. J Nutr 2000;130:496S-502S.
32. Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 1994;91:10771-8.
33. Smith AD. Homocysteine, B vitamins, and cognitive deficit in the elderly. Am J Clin Nutr 2002;75:785-6.
34. Stevens LJ, Zentall SS, Deck JL, et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 1995;62:761-8.
35. Tamura T, Goldenberg RL, Hou J, et al. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr 2002;140:165-70.
36. Walter PB, Knutson MD, Paler-Martinez A, et al. Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci USA 2002;99:2264-9.